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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 195 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of TSC1 Tuberous sclerosis complex( TSC) is a tumor suppressor gene syndrome caused by mutations in TSC1 and TSC2. Tuberous sclerosis is an autosomal dominant hereditary disease caused by mutations in either the TSC1 or the TSC2 tumor suppressor gene. Pathogenesis of tuberous...
Mus musculus
Gene: ... Disease relevance of Tsc1 Liver hemangiomas were more common, more severe and caused higher mortality in female than in male Tsc1 heterozygotes. Tsc1 heterozygotes develop kidney cystadenomas... heterozygote mice. Loss of tuberous sclerosis complex 1( Tsc1) expression results in increased Rheb/ S6K...
Drosophila melanogaster
Gene: ... Disease relevance of Tsc1 Tuberous sclerosis complex( TSC) is a genetic disorder caused by mutations in one of two tumor suppressor genes, TSC1 and TSC2. Germline mutations in either TSC1 or TSC2... normal allele. High impact information on Tsc1 In a screen for patterning mutants, we isolated alleles... / Synonyms: TSC1; dTSC-1; dTSC1
Rattus norvegicus
Gene: ... cell carcinomas( RCs) with a complete penetrance in all heterozygotes. Associations of Tsc1...Disease relevance of Tsc1 Mutations of the TSC2 gene lead to the development of hamartomas... mutations in the TSC1 or TSC2 genes, which encode hamartin and tuberin, respectively. Alterations in the rat...
MeSH term: ... Disease relevance of Tuberous Sclerosis Loss of the tumour- suppressor gene TSC1 is responsible... and inhibiting tuberous sclerosis complex 2( TSC2). The tuberous sclerosis complex( TSC1- 2) suppresses cell...( TSC) genes, TSC1 or TSC2. Tuberin, the protein product of the tuberous sclerosis complex- 2( TSC2...
Danio rerio
Gene: Synonyms: tsc1
MeSH term: ... - induced lymphomagenesis, resulting in highly disseminated disease. Mutations in either the TSC1 or TSC2... in the p53 tumor suppressor gene were methylated in all normal human tissues analyzed. This family includes...
MeSH term: ... we report the first evidence of loss of heterozygosity at the TSC1 critical region in a giant cell... protooncogene and the PDGF- R gene in all astrocytomas examined. In situ hybridization of astrocytoma tissue...
MeSH term: ... was significantly less frequent among carriers of TSC1 than TSC2 mutations( odds ratio 5. 54 for sporadic cases only...
MeSH term: ... LOH, scanning of all exons of both TSC1 and TSC2, promoter methylation of TSC2, and clonality analysis... disorder in which benign hamartomas develop in multiple organs, caused by mutations in either TSC1 or TSC2... of heterozygosity( LOH) is known to occur in these hamartomas at loci of both TSC1 and TSC2. Tuberous sclerosis...

 

 
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