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Gene Review

Tsc1  -  CG6147 gene product from transcript CG6147-RA

Drosophila melanogaster

Synonyms: CG6147, Dmel\CG6147, TSC, TSC1, dTSC, ...
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Disease relevance of Tsc1


High impact information on Tsc1

  • In a screen for patterning mutants, we isolated alleles of tsc1, a component of the insulin receptor (InR) growth control pathway [3].
  • We find that loss of tsc1 disrupts patterning due to a loss of temporal control of differentiation. tsc1 controls the timing of differentiation downstream or in parallel to the RAS/MAPK pathway [3].
  • We have characterized mutations in the Drosophila Tsc1 and Tsc2/gigas genes [4].
  • Coexpression of both Tsc1 and Tsc2 restricts tissue growth and reduces cell size and cell proliferation [4].
  • Genetic epistasis data are consistent with a model that Tsc1 and Tsc2 function together in the insulin signaling pathway [5].

Biological context of Tsc1

  • Overexpression of Tsc1 or Tsc2 alone in the wing and eye has no effect, but co-overexpression leads to a decrease in cell size, cell number, and organ size [5].
  • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size [5].
  • Clones of Tsc1 mutant cells in the imaginal discs undergo additional divisions but retain normal ploidy [5].
  • Unlike previous studies, our work shows that TSC1(-) or TSC2(-) cells are diploid [6].
  • TSC1 downregulates the insulin-mediated signal transduction pathway, and serves as a metabolic control to guard against cellular overproliferation and tumorogenesis in both flies and mammals [7].

Anatomical context of Tsc1


Associations of Tsc1 with chemical compounds

  • Tuberin and hamartin function together as a complex in mammals and Drosophila [8].


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