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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Tuberous Sclerosis

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Disease relevance of Tuberous Sclerosis


Psychiatry related information on Tuberous Sclerosis


High impact information on Tuberous Sclerosis


Chemical compound and disease context of Tuberous Sclerosis


Biological context of Tuberous Sclerosis


Anatomical context of Tuberous Sclerosis


Gene context of Tuberous Sclerosis


Analytical, diagnostic and therapeutic context of Tuberous Sclerosis


  1. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Lamb, R.F., Roy, C., Diefenbach, T.J., Vinters, H.V., Johnson, M.W., Jay, D.G., Hall, A. Nat. Cell Biol. (2000) [Pubmed]
  2. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Carsillo, T., Astrinidis, A., Henske, E.P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Images in cardiovascular medicine. Cardiac rhabdomyomas in tuberous sclerosis (Bourneville's disease). Guerrero, H., Campos, P., Harrison, C. Circulation (1994) [Pubmed]
  4. Regulation of mTOR and cell growth in response to energy stress by REDD1. Sofer, A., Lei, K., Johannessen, C.M., Ellisen, L.W. Mol. Cell. Biol. (2005) [Pubmed]
  5. Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas. Wienecke, R., Guha, A., Maize, J.C., Heideman, R.L., DeClue, J.E., Gutmann, D.H. Ann. Neurol. (1997) [Pubmed]
  6. Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features. Bjornsson, J., Short, M.P., Kwiatkowski, D.J., Henske, E.P. Am. J. Pathol. (1996) [Pubmed]
  7. Cranial computed tomographic findings in tuberous sclerosis are not affected by sex. Clarke, A., Cook, P., Osborne, J.P. Developmental medicine and child neurology. (1996) [Pubmed]
  8. gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Ito, N., Rubin, G.M. Cell (1999) [Pubmed]
  9. Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease. Kandt, R.S., Haines, J.L., Smith, M., Northrup, H., Gardner, R.J., Short, M.P., Dumars, K., Roach, E.S., Steingold, S., Wall, S. Nat. Genet. (1992) [Pubmed]
  10. Tsc2 is not a critical target of Akt during normal Drosophila development. Dong, J., Pan, D. Genes Dev. (2004) [Pubmed]
  11. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. Harrington, L.S., Findlay, G.M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N.R., Cheng, S., Shepherd, P.R., Gout, I., Downes, C.P., Lamb, R.F. J. Cell Biol. (2004) [Pubmed]
  12. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Soucek, T., Yeung, R.S., Hengstschläger, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  13. Pancreatitis induced by valproic acid: report of a case. Taira, N., Nishi, H., Mano, M., Waki, N., Tsugita, Y., Takashima, S., Fukuda, K., Komatsubara, S. Surgery today. (2001) [Pubmed]
  14. Tc-99m HDP bone scan showing bone changes in a case of tuberous sclerosis or Bourneville's disease. Jonard, P., Lonneux, M., Boland, B., Malghem, J., Jamar, F. Clinical nuclear medicine. (2001) [Pubmed]
  15. Evidence for genetic heterogeneity in tuberous sclerosis: one locus on chromosome 9 and at least one locus elsewhere. Northrup, H., Kwiatkowski, D.J., Roach, E.S., Dobyns, W.B., Lewis, R.A., Herman, G.E., Rodriguez, E., Daiger, S.P., Blanton, S.H. Am. J. Hum. Genet. (1992) [Pubmed]
  16. Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis. Crooks, D.M., Pacheco-Rodriguez, G., DeCastro, R.M., McCoy, J.P., Wang, J.A., Kumaki, F., Darling, T., Moss, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  17. High rate of mosaicism in tuberous sclerosis complex. Verhoef, S., Bakker, L., Tempelaars, A.M., Hesseling-Janssen, A.L., Mazurczak, T., Jozwiak, S., Fois, A., Bartalini, G., Zonnenberg, B.A., van Essen, A.J., Lindhout, D., Halley, D.J., van den Ouweland, A.M. Am. J. Hum. Genet. (1999) [Pubmed]
  18. Aberrant beta-catenin signaling in tuberous sclerosis. Mak, B.C., Kenerson, H.L., Aicher, L.D., Barnes, E.A., Yeung, R.S. Am. J. Pathol. (2005) [Pubmed]
  19. Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells. Uhlmann, E.J., Apicelli, A.J., Baldwin, R.L., Burke, S.P., Bajenaru, M.L., Onda, H., Kwiatkowski, D., Gutmann, D.H. Oncogene (2002) [Pubmed]
  20. Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Maldonado, M., Baybis, M., Newman, D., Kolson, D.L., Chen, W., McKhann, G., Gutmann, D.H., Crino, P.B. Neurobiol. Dis. (2003) [Pubmed]
  21. Regulation of cell morphology and adhesion by the tuberous sclerosis complex (TSC1/2) gene products in human kidney epithelial cells through increased E-cadherin/beta-catenin activity. Li, S., Braverman, R., Li, H., Vass, W.C., Lowy, D.R., DeClue, J.E. Mol. Carcinog. (2003) [Pubmed]
  22. Magnetization transfer ratio measurements of the brain in children with tuberous sclerosis complex. Zikou, A., Ioannidou, M.C., Tzoufi, M., Astrakas, L., Argyropoulou, M.I. Pediatric radiology. (2005) [Pubmed]
  23. Tuberous sclerosis complex with disseminated telencephalic distribution of atypical cells and their relation to corticogenesis. Röske, B., Stoltenburg, G., Baier, P.M., König, R., Schlote, W. Clin. Neuropathol. (2003) [Pubmed]
  24. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Inoki, K., Li, Y., Xu, T., Guan, K.L. Genes Dev. (2003) [Pubmed]
  25. Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients. Au, K.S., Rodriguez, J.A., Finch, J.L., Volcik, K.A., Roach, E.S., Delgado, M.R., Rodriguez, E., Northrup, H. Am. J. Hum. Genet. (1998) [Pubmed]
  26. Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Uhlmann, E.J., Li, W., Scheidenhelm, D.K., Gau, C.L., Tamanoi, F., Gutmann, D.H. Glia (2004) [Pubmed]
  27. mTOR, translational control and human disease. Tee, A.R., Blenis, J. Semin. Cell Dev. Biol. (2005) [Pubmed]
  28. Genetic alterations in urothelial bladder carcinoma: an updated review. Mhawech-Fauceglia, P., Cheney, R.T., Schwaller, J. Cancer (2006) [Pubmed]
  29. Emerging clinical picture of lymphangioleiomyomatosis. Cohen, M.M., Pollock-BarZiv, S., Johnson, S.R. Thorax (2005) [Pubmed]
  30. Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex. Wu, J.Y., Sutherling, W.W., Koh, S., Salamon, N., Jonas, R., Yudovin, S., Sankar, R., Shields, W.D., Mathern, G.W. Neurology (2006) [Pubmed]
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