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Chemical Compound Review

Coumarin 151     7-amino-4- (trifluoromethyl)chromen-2- one

Synonyms: PubChem8665, AG-C-08895, AG-F-83970, CHEMBL1301731, regid857055, ...
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Disease relevance of AIDS-129219


High impact information on AIDS-129219

  • The Michaelis-Menten constant for GP testicular acrosin-catalyzed hydrolysis of the N-benzyloxycarbonyl-L-arginyl amide of 7-amino-4-trifluoromethylcoumarin at pH 8.0 was calculated from Lineweaver-Burk plots to give a value of Km = 2.0 x 10(-5) M with Vmax = 500 mumoles/min/mg protein [2].
  • Amino acid or peptide derivatives of naphthylamine AS can be recommended for light microscopical localization and cytofluorometric quantification, and 7-amino-4-methylcoumarin and 7-amino-4-trifluoromethylcoumarin amino acids and peptides for the development of enzyme bands after isoelectric focusing [3].
  • The histochemical localization of u-PA activity is done by the methods of Lojda using unfixed cryostat sections on semipermeable membranes and a gel incubation medium containing sensitive substrates with the 7-amino-4-trifluoromethylcoumarin (AFC) (Enzyme Systems Products, Sierra Lane, Dublin, CA, USA) leaving groups [4].

Biological context of AIDS-129219


  1. Flow cytometric analysis of protease activities in vital cells. Rothe, G., Klingel, S., Assfalg-Machleidt, I., Machleidt, W., Zirkelbach, C., Banati, R.B., Mangel, W.F., Valet, G. Biol. Chem. Hoppe-Seyler (1992) [Pubmed]
  2. Guinea pig testicular proacrosin-acrosin system: further characterization of the active enzyme. Adekunle, A.O., Storey, B.T., Teuscher, C. Biol. Reprod. (1989) [Pubmed]
  3. Cytochemistry of membrane proteases. Gossrau, R. Histochem. J. (1985) [Pubmed]
  4. The appearance and possible role of plasminogen activator of urokinase type (u-PA) activity in the cornea related to soft contact lens wear in rabbits. Cejková, J. Documenta ophthalmologica. Advances in ophthalmology. (1998) [Pubmed]
  5. Purification and initial characterization of guinea pig testicular acrosin. Adekunle, A.O., Arboleda, C.E., Zervos, P.H., Gerton, G.L., Teuscher, C. Biol. Reprod. (1987) [Pubmed]
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