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Chemical Compound Review

Coumarin 120     7-amino-4-methyl-chromen-2-one

Synonyms: PubChem11097, NH2Mec, CHEMBL270672, CCRIS 4961, QC-910, ...
 
 
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Disease relevance of NH2Mec

 

High impact information on NH2Mec

 

Biological context of NH2Mec

 

Associations of NH2Mec with other chemical compounds

  • Substrates which contain an ANSN leaving group had a higher affinity for tPA than substrates with p-nitroaniline or 7-amino-4-methylcoumarin leaving groups [13].
  • Cathepsin L-like activity was demonstrated in the excretory/secretory (E/S) products of Fasciola hepatica newly excysted juveniles (NEJ), 3-week-old, 5-week-old and mature flukes using the fluorogenic substituted 7-amino-4-methylcoumarin substrates Z-phe-arg-AMC, Z-arg-arg-AMC and Z-arg-AMC [14].
  • Unlike some of the other coumarin dyes, namely coumarin-120 (C120) (4-CH3-7-NH2-1,2-benzopyrone) and coumarin-151 (C151) 4-CF3-7-NH2-1,2-benzopyrone), which also show similar structural changes in nonpolar and other solvents, the C7 dye does not show any activation-controlled deexcitation process in nonpolar solvents [15].
  • A Toxoplasma gondii aminopeptidase specific for the fluorogenic substrate L-arginine 7-amino-4-methylcoumarin was identified in cell-free extract [16].
  • Therefore, the ratio alpha/r(3) for each dye is calculated to be 0.93, 0.79, 0.39, 0.37, 0.67 and 0.76 for DSP, P2VB, Bis-MSB, APMAA, RB and C120, respectively [17].
 

Gene context of NH2Mec

 

Analytical, diagnostic and therapeutic context of NH2Mec

References

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