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Chemical Compound Review:

CCRIS 8956 dimethylarsorylmethane

Synonyms: AG-F-66132, CHEBI:27131, AC1L2XQN, LS-21877, CTK4J1479, ...

Cohen, S.M. et al., Kuroda, K. et al., Marafante, E. et al.

Kuroda, Yoshida, Yoshimura, Endo, Wanibuchi, Fukushima, Endo, Cohen, Arnold, Uzvolgyi, Cano, St John, Yamamoto, Lu, Le,

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Disease relevance of dimethylarsorylmethane

Escherichia coli A3-6 isolated from a rat yielded two unknown arsenic compounds (M-2 and M-3) from dimethylarsinic acid and M-1 from trimethylarsine oxide (TMAO) in the presence of cysteine (Cys) [1].

High impact information on dimethylarsorylmethane

Using rat (MYP3) and human (1T1) urothelial cells, cytotoxicity for trivalent arsenicals, sodium arsenite, monomethylarsonous acid (MMA(III)), and DMA(III) was demonstrated at 0.4-4.8 microM concentrations, whereas MMA(V), DMA(V), and TMAO were cytotoxic at millimolar concentrations [2].
No TMAO was found in feces [3].

References

Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic. Kuroda, K., Yoshida, K., Yoshimura, M., Endo, Y., Wanibuchi, H., Fukushima, S., Endo, G. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Cohen, S.M., Arnold, L.L., Uzvolgyi, E., Cano, M., St John, M., Yamamoto, S., Lu, X., Le, X.C. Chem. Res. Toxicol. (2002) [Pubmed]
Biotransformation of dimethylarsinic acid in mouse, hamster and man. Marafante, E., Vahter, M., Norin, H., Envall, J., Sandström, M., Christakopoulos, A., Ryhage, R. Journal of applied toxicology : JAT. (1987) [Pubmed]

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