The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

ARSENIC     arsenic

Synonyms: arsenico, arsenicum, Arsenicals, Arsen, Arsenowodor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of arsenic


Psychiatry related information on arsenic

  • Animals exposed to different concentrations of test chemicals (Copper, Arsenic and HCH) showed prominent behavioural/morphological alterations viz., coughing, redness on the ventral side, paralysis and disorientation in scaphognathite activity [6].

High impact information on arsenic


Chemical compound and disease context of arsenic


Biological context of arsenic


Anatomical context of arsenic


Associations of arsenic with other chemical compounds


Gene context of arsenic


Analytical, diagnostic and therapeutic context of arsenic


  1. Letter: Arsenic and non-cirrhotic portal hypertension. Datta, D.V. Lancet (1976) [Pubmed]
  2. Noncirrhotic presinusoidal portal hypertension associated with chronic arsenical intoxication. Huet, P.M., Guillaume, E., Cote, J., Légaré, A., Lavoie, P., Viallet, A. Gastroenterology (1975) [Pubmed]
  3. Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ohnishi, K., Yoshida, H., Shigeno, K., Nakamura, S., Fujisawa, S., Naito, K., Shinjo, K., Fujita, Y., Matsui, H., Takeshita, A., Sugiyama, S., Satoh, H., Terada, H., Ohno, R. Ann. Intern. Med. (2000) [Pubmed]
  4. Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells. Estrov, Z., Manna, S.K., Harris, D., Van, Q., Estey, E.H., Kantarjian, H.M., Talpaz, M., Aggarwal, B.B. Blood (1999) [Pubmed]
  5. Buthionine Sulfoximine Enhancement of Arsenic Trioxide-Induced Apoptosis in Leukemia and Lymphoma Cells Is Mediated via Activation of c-Jun NH2-Terminal Kinase and Up-regulation of Death Receptors. Chen, D., Chan, R., Waxman, S., Jing, Y. Cancer Res. (2006) [Pubmed]
  6. Acute toxicity evaluation of copper, arsenic and HCH to paddy field crab, Paratelphusa hydrodromus (Herb.). Vardhanan, Y.S., Radhakrishnan, T. Journal of environmental biology / Academy of Environmental Biology, India. (2002) [Pubmed]
  7. Toxicology. Arsenic researchers face isotope shortage. Kaiser, J. Science (2000) [Pubmed]
  8. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. Zhu, X.H., Shen, Y.L., Jing, Y.K., Cai, X., Jia, P.M., Huang, Y., Tang, W., Shi, G.Y., Sun, Y.P., Dai, J., Wang, Z.Y., Chen, S.J., Zhang, T.D., Waxman, S., Chen, Z., Chen, G.Q. J. Natl. Cancer Inst. (1999) [Pubmed]
  9. Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Mukhopadhyay, R., Dey, S., Xu, N., Gage, D., Lightbody, J., Ouellette, M., Rosen, B.P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Microbial arsenic: from geocycles to genes and enzymes. Mukhopadhyay, R., Rosen, B.P., Phung, L.T., Silver, S. FEMS Microbiol. Rev. (2002) [Pubmed]
  11. Role of cysteinyl residues in metalloactivation of the oxyanion-translocating ArsA ATPase. Bhattacharjee, H., Li, J., Ksenzenko, M.Y., Rosen, B.P. J. Biol. Chem. (1995) [Pubmed]
  12. Metalloregulated expression of the ars operon. Wu, J., Rosen, B.P. J. Biol. Chem. (1993) [Pubmed]
  13. Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism. Nishikawa, T., Wanibuchi, H., Ogawa, M., Kinoshita, A., Morimura, K., Hiroi, T., Funae, Y., Kishida, H., Nakae, D., Fukushima, S. Int. J. Cancer (2002) [Pubmed]
  14. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Cohen, S.M., Arnold, L.L., Uzvolgyi, E., Cano, M., St John, M., Yamamoto, S., Lu, X., Le, X.C. Chem. Res. Toxicol. (2002) [Pubmed]
  15. Direct cardiac effects of As2O3 in rabbits: evidence of reversible chronic toxicity and tissue accumulation of arsenicals after parenteral administration. Wu, M.H., Lin, C.J., Chen, C.L., Su, M.J., Sun, S.S., Cheng, A.L. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  16. Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase. Wu, J., Tisa, L.S., Rosen, B.P. J. Biol. Chem. (1992) [Pubmed]
  17. Mutagenesis of the C-terminal nucleotide-binding site of an anion-translocating ATPase. Kaur, P., Rosen, B.P. J. Biol. Chem. (1992) [Pubmed]
  18. A kinetic model for the action of a resistance efflux pump. Walmsley, A.R., Zhou, T., Borges-Walmsley, M.I., Rosen, B.P. J. Biol. Chem. (2001) [Pubmed]
  19. Arsenic Trioxide Affects Signal Transducer and Activator of Transcription Proteins through Alteration of Protein Tyrosine Kinase Phosphorylation. Wetzler, M., Brady, M.T., Tracy, E., Li, Z.R., Donohue, K.A., O'loughlin, K.L., Cheng, Y., Mortazavi, A., McDonald, A.A., Kunapuli, P., Wallace, P.K., Baer, M.R., Cowell, J.K., Baumann, H. Clin. Cancer Res. (2006) [Pubmed]
  20. Speciation of key arsenic metabolic intermediates in human urine. Le, X.C., Lu, X., Ma, M., Cullen, W.R., Aposhian, H.V., Zheng, B. Anal. Chem. (2000) [Pubmed]
  21. Iodophenylarsine oxide and arsenical affinity chromatography: new probes for dithiol proteins. Application to tubulins and to components of the insulin receptor-glucose transporter signal transduction pathway. Hoffman, R.D., Lane, M.D. J. Biol. Chem. (1992) [Pubmed]
  22. Methylated trivalent arsenic species are genotoxic. Mass, M.J., Tennant, A., Roop, B.C., Cullen, W.R., Styblo, M., Thomas, D.J., Kligerman, A.D. Chem. Res. Toxicol. (2001) [Pubmed]
  23. Arsenic trioxide in patients with hepatocellular carcinoma: a phase II trial. Lin, C.C., Hsu, C., Hsu, C.H., Hsu, W.L., Cheng, A.L., Yang, C.H. Investigational new drugs (2007) [Pubmed]
  24. Tissue retention of arsenic in rats fed witch founder or cacodylic acid. Siewicki, T.C. J. Nutr. (1981) [Pubmed]
  25. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Lin, S., Del Razo, L.M., Styblo, M., Wang, C., Cullen, W.R., Thomas, D.J. Chem. Res. Toxicol. (2001) [Pubmed]
  26. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Yamamoto, S., Konishi, Y., Matsuda, T., Murai, T., Shibata, M.A., Matsui-Yuasa, I., Otani, S., Kuroda, K., Endo, G., Fukushima, S. Cancer Res. (1995) [Pubmed]
  27. Use of cationic disc electrophoresis near neutral pH in the evaluation of trace proteins in human plasma. Young, C.W., Dessources, W., Hodas, S., Bittar, E.S. Cancer Res. (1975) [Pubmed]
  28. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. De Koning, H.P. Mol. Pharmacol. (2001) [Pubmed]
  29. Regulation of immune-aggregate-stimulated hepatic glycogenolysis and vasoconstriction by vicinal dithiols. Steinhelper, M.E., Olson, M.S. Biochem. J. (1988) [Pubmed]
  30. Evidence for the existence of a channel in the glucose-specific carrier EIIGlc of the Salmonella typhimurium phosphoenolpyruvate-dependent phosphotransferase system. Robillard, G.T., Beechey, R.B. Biochemistry (1986) [Pubmed]
  31. ATR, PML, and CHK2 Play a Role in Arsenic Trioxide-induced Apoptosis. Joe, Y., Jeong, J.H., Yang, S., Kang, H., Motoyama, N., Pandolfi, P.P., Chung, J.H., Kim, M.K. J. Biol. Chem. (2006) [Pubmed]
  32. Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes. Tanaka-Kagawa, T., Hanioka, N., Yoshida, H., Jinno, H., Ando, M. Br. J. Dermatol. (2003) [Pubmed]
  33. Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals. Liu, J., Liu, Y., Goyer, R.A., Achanzar, W., Waalkes, M.P. Toxicol. Sci. (2000) [Pubmed]
  34. Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Germolec, D.R., Spalding, J., Yu, H.S., Chen, G.S., Simeonova, P.P., Humble, M.C., Bruccoleri, A., Boorman, G.A., Foley, J.F., Yoshida, T., Luster, M.I. Am. J. Pathol. (1998) [Pubmed]
  35. Mercury-induced transitions between right-handed and putative left-handed forms of poly[d(A-T).d(A-T)] and poly[d(G-C).d(G-C)]. Gruenwedel, D.W., Cruikshank, M.K. Nucleic Acids Res. (1989) [Pubmed]
  36. Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study. Chen, Y., Factor-Litvak, P., Howe, G.R., Parvez, F., Ahsan, H. Am. J. Clin. Nutr. (2006) [Pubmed]
  37. A high-efficiency photooxidation reactor for speciation of organic arsenicals by liquid chromatography-hydride generation-ICPMS. Nakazato, T., Tao, H. Anal. Chem. (2006) [Pubmed]
  38. Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine. Waters, S.B., Devesa, V., Fricke, M.W., Creed, J.T., Stýblo, M., Thomas, D.J. Chem. Res. Toxicol. (2004) [Pubmed]
WikiGenes - Universities