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Chemical Compound Review

cacodylic acid     dimethylarsinic acid

Synonyms: Alkargen, Chexmate, Silvisad, Silvisar, Sylvicor, ...
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Disease relevance of cacodylic acid


High impact information on cacodylic acid


Chemical compound and disease context of cacodylic acid


Biological context of cacodylic acid


Anatomical context of cacodylic acid


Associations of cacodylic acid with other chemical compounds


Gene context of cacodylic acid


Analytical, diagnostic and therapeutic context of cacodylic acid


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  4. Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic. Kuroda, K., Yoshida, K., Yoshimura, M., Endo, Y., Wanibuchi, H., Fukushima, S., Endo, G. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  5. In vitro activity of dimethylarsinic acid against human leukemia and multiple myeloma cell lines. Duzkale, H., Jilani, I., Orsolic, N., Zingaro, R.A., Golemovic, M., Giles, F.J., Kantarjian, H., Albitar, M., Freireich, E.J., Verstovsek, S. Cancer Chemother. Pharmacol. (2003) [Pubmed]
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  7. Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice. Salim, E.I., Wanibuchi, H., Morimura, K., Wei, M., Mitsuhashi, M., Yoshida, K., Endo, G., Fukushima, S. Carcinogenesis (2003) [Pubmed]
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  9. Chromatographic separation and identification of products from the reaction of dimethylarsinic acid with hydrogen sulfide. Fricke, M.W., Zeller, M., Sun, H., Lai, V.W., Cullen, W.R., Shoemaker, J.A., Witkowski, M.R., Creed, J.T. Chem. Res. Toxicol. (2005) [Pubmed]
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  14. In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Juhasz, A.L., Smith, E., Weber, J., Rees, M., Rofe, A., Kuchel, T., Sansom, L., Naidu, R. Environ. Health Perspect. (2006) [Pubmed]
  15. Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. Zakharyan, R.A., Wildfang, E., Aposhian, H.V. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
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  17. Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats. Yoshida, K., Kuroda, K., Zhou, X., Inoue, Y., Date, Y., Wanibuchi, H., Fukushima, S., Endo, G. Chem. Res. Toxicol. (2003) [Pubmed]
  18. Endonuclease III, formamidopyrimidine-DNA glycosylase, and proteinase K additively enhance arsenic-induced DNA strand breaks in human cells. Wang, T.S., Chung, C.H., Wang, A.S., Bau, D.T., Samikkannu, T., Jan, K.Y., Cheng, Y.M., Lee, T.C. Chem. Res. Toxicol. (2002) [Pubmed]
  19. Role of mitotic motors, dynein and kinesin, in the induction of abnormal centrosome integrity and multipolar spindles in cultured V79 cells exposed to dimethylarsinic acid. Ochi, T. Mutat. Res. (2002) [Pubmed]
  20. Aneuploidy induced by dimethylarsinic acid in mouse bone marrow cells. Kashiwada, E., Kuroda, K., Endo, G. Mutat. Res. (1998) [Pubmed]
  21. DNA-protein cross-links and sister chromatid exchanges induced by dimethylarsinic acid in human fibroblasts cells. Mourón, S.A., Grillo, C.A., Dulout, F.N., Golijow, C.D. Mutat. Res. (2005) [Pubmed]
  22. Association between arsenic exposure from a coal-burning power plant and urinary arsenic concentrations in Prievidza District, Slovakia. Ranft, U., Miskovic, P., Pesch, B., Jakubis, P., Fabianova, E., Keegan, T., Hergemöller, A., Jakubis, M., Nieuwenhuijsen, M.J. Environ. Health Perspect. (2003) [Pubmed]
  23. Stability of arsenic species and insoluble arsenic in human urine. Chen, Y.C., Amarasiriwardena, C.J., Hsueh, Y.M., Christiani, D.C. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
  24. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Namgung, U., Xia, Z. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  25. Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis. Yamanaka, K., Takabayashi, F., Mizoi, M., An, Y., Hasegawa, A., Okada, S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  26. Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice. Morikawa, T., Wanibuchi, H., Morimura, K., Ogawa, M., Fukushima, S. Jpn. J. Cancer Res. (2000) [Pubmed]
  27. Decreased enzyme activity of hepatic thioredoxin reductase and glutathione reductase in rabbits by prolonged exposure to inorganic arsenate. Nikaido, M., Pi, J., Kumagai, Y., Yamauchi, H., Taguchi, K., Horiguchi, S., Sun, Y., Sun, G., Shimojo, N. Environ. Toxicol. (2003) [Pubmed]
  28. Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics. Yamanaka, K., Hayashi, H., Tachikawa, M., Kato, K., Hasegawa, A., Oku, N., Okada, S. Mutat. Res. (1997) [Pubmed]
  29. Metallothionein (I/II) suppresses genotoxicity caused by dimethylarsinic acid. Jia, G., Sone, H., Nishimura, N., Satoh, M., Tohyama, C. Int. J. Oncol. (2004) [Pubmed]
  30. Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: association with elevated ornithine decarboxylase activity and formation of 8-hydroxydeoxyguanosine in the liver. Wanibuchi, H., Hori, T., Meenakshi, V., Ichihara, T., Yamamoto, S., Yano, Y., Otani, S., Nakae, D., Konishi, Y., Fukushima, S. Jpn. J. Cancer Res. (1997) [Pubmed]
  31. Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats. Wei, M., Wanibuchi, H., Yamamoto, S., Li, W., Fukushima, S. Carcinogenesis (1999) [Pubmed]
  32. Current and emerging challenges in toxicopathology: Carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens. Fukushima, S., Morimura, K., Wanibuchi, H., Kinoshita, A., Salim, E.I. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  33. Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography/mass spectrometry. Mester, Z., Horváth, G., Vitányi, G., Lelik, L., Fodor, P. Rapid Commun. Mass Spectrom. (1999) [Pubmed]
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