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Chemical Compound Review:

Pentamethonum trimethyl-(5- trimethylammoniopentyl)azanium

Synonyms: Pentamethonium, AC1L1W8E, 2365-25-5, UNII-521DS2D2HB, 541-20-8 (dibromide), ...

Devaux, M.A. et al., Berger, Z. et al.

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Disease relevance of NSC148343

Atropine caused a dose-dependent (10(-7) M, 10(-6) M) decrease in the maximal response (non-competitive antagonism), while the ganglion blocker pentamethonium (10(-4) M) was without effect [1].

High impact information on NSC148343

1 The effects of pentamethonium, an autonomic ganglion blocker, were studied on the exocrine pancreatic secretion of six conscious dogs given intravenous infusions of urecholine, caerulein or pentagastrin on a background of submaximal doses of secretin [2].

References

Dopamine, noradrenaline and isoprenaline: secretory and electrophysiological effects in vitro on mouse pancreas. Berger, Z., Laugier, R. J. Physiol. (Lond.) (1986) [Pubmed]
The role of nicotinic receptors in dog pancreatic exocrine secretion. Devaux, M.A., Diaz, G.R., Kubota, K., Magee, D.F., Sarles, H. Br. J. Pharmacol. (1983) [Pubmed]

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