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Chemical Compound Review

pentagastrin     3-[(1-aminocarbonyl-2- phenyl...

Synonyms: SureCN26046, AGN-PC-00OIPQ, B1636_SIGMA, CHEBI:113992, NSC-367746, ...
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Disease relevance of pentagastrin


Psychiatry related information on pentagastrin


High impact information on pentagastrin


Chemical compound and disease context of pentagastrin


Biological context of pentagastrin


Anatomical context of pentagastrin


Associations of pentagastrin with other chemical compounds

  • This same dose of PYY maximally inhibited histamine- and pentagastrin-stimulated acid secretion by 28 +/- 7% (P less than 0.05), and 17 +/- 4% (P less than 0.05), respectively [31].
  • The gastric inhibitory action of intracerebroventricularly administered CRF on pentagastrin-stimulated gastric acid secretion was completely abolished by ganglionic blockade with chlorisondamine [27].
  • Morphologically typical ulcers were produced in the first part of the duodenum in 300 male Wistar rats by subcutaneous infusion for 24 hr of pentagastrin (4 mug per kg-min) and carbachol (0.8 mug per kg-min) [32].
  • Ninety minutes after mucosal exposure to 2 M NaCl there was an almost complete restitution of the gastric surface epithelium in pentagastrin-stimulated and cimetidine-treated animals, whereas about 15% of the gastric surface still showed damage in animals in which acid secretion was not interfered with [33].
  • CONCLUSIONS: The significantly higher gland luminal pressure after treatment with omeprazole, compared with the values during pentagastrin or vehicle infusion, cannot be explained by increased mucus thickness [34].

Gene context of pentagastrin


Analytical, diagnostic and therapeutic context of pentagastrin

  • By parallel line bioassay non-DU subjects required 2.8 times more pentagastrin (95% confidence limits 2.1-3.7) than DU highest response [5].
  • Intravenous infusion of pentagastrin (0.1--0.4 microgram/kg/min) resulted in an increase in acid output in desalivated rats although the responses was less than that observed in sham-operated controls [39].
  • After bilateral transthoracic vagotomy, pentagastrin infusion still interrupted the complex but now, in addition, upon stopping the pentagastrin, a premature activity front (phase III) of the complex was also followed by a reduction in the temporal regularity of the cycles of the complex [40].
  • Inclusion of pentagastrin in the perfusion buffer increased acid output from 2.2 +/- 0.4 microEq H+/h during control perfusion to 18.8 +/- 1.8 microEq H+/h (p less than 0.01) [41].
  • In 8 nonoperated DU subjects and in 5 DU patients subjected to proximal gastric vagotomy, low grade fundic distention moderately enhanced the acid output evoked by a threshold dose of pentagastrin [23].


  1. Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A. Lips, C.J., Landsvater, R.M., Höppener, J.W., Geerdink, R.A., Blijham, G., van Veen, J.M., van Gils, A.P., de Wit, M.J., Zewald, R.A., Berends, M.J. N. Engl. J. Med. (1994) [Pubmed]
  2. The carcinoid flush. Provocation by pentagastrin and inhibition by somatostatin. Frölich, J.C., Bloomgarden, Z.T., Oates, J.A., McGuigan, J.E., Rabinowitz, D. N. Engl. J. Med. (1978) [Pubmed]
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  4. Atrial fibrillation after administration of calcium and pentagastrin. Drucker, D. N. Engl. J. Med. (1981) [Pubmed]
  5. Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer. Isenberg, J.I., Grossman, M.I., Maxwell, V., Walsh, J.H. J. Clin. Invest. (1975) [Pubmed]
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  7. Central vagal activation increases mucus gel thickness and surface cell intracellular pH in rat stomach. Tanaka, S., Taché, Y., Kaneko, H., Guth, P.H., Kaunitz, J.D. Gastroenterology (1997) [Pubmed]
  8. Effects of the cholecystokinin agonist pentagastrin in patients with generalized anxiety disorder. Brawman-Mintzer, O., Lydiard, R.B., Bradwejn, J., Villarreal, G., Knapp, R., Emmanuel, N., Ware, M.R., He, Q., Ballenger, J.C. The American journal of psychiatry. (1997) [Pubmed]
  9. Pentagastrin-induced sleep panic attacks: panic in the absence of elevated baseline arousal. Geraci, M., Anderson, T.S., Slate-Cothren, S., Post, R.M., McCann, U.D. Biol. Psychiatry (2002) [Pubmed]
  10. Anxiogenic effects of pentagastrin in patients with social phobia and healthy controls. van Vliet, I.M., Westenberg, H.G., Slaap, B.R., den Boer, J.A., Ho Pian, K.L. Biol. Psychiatry (1997) [Pubmed]
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  12. Natural history of familial medullary thyroid carcinoma: effect of a program for early diagnosis. Graze, K., Spiler, I.J., Tashjian, A.H., Melvin, K.E., Cervi-Skinner, S., Gagel, R.F., Miller, H.H., Wolfe, H.J., DeLellis, R.A., Leape, L., Feldman, Z.T., Reichlin, S. N. Engl. J. Med. (1978) [Pubmed]
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  14. Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats. Tepperman, B.L., Evered, M.D. Science (1980) [Pubmed]
  15. Increased sensitivity of gastric acid secretion to gastrin in cirrhotic patients with portacaval shunt. Lenz, H.J., Struck, T., Greten, H., Koss, M.A., Eysselein, V.E., Walsh, J.H., Isenberg, J.I. J. Clin. Invest. (1987) [Pubmed]
  16. Fundic inhibition of acid secretion and gastrin release in the dog. Soon-Shiong, P., Debas, H.T. Gastroenterology (1980) [Pubmed]
  17. Influence of the stimulation state of the parietal cells on the inhibitory effect of omeprazole on gastric acid secretion in dogs. De Graef, J., Woussen-Colle, M.C. Gastroenterology (1986) [Pubmed]
  18. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Smith, J.P., Solomon, T.E. Gastroenterology (1988) [Pubmed]
  19. Effect of bethanechol (urecholine) on gastric acid and nonparietal secretion in normal subjects and duodenal ulcer patients. Comparison with atropine, pentagastrin, and histamine. Feldman, M., Schiller, L. Gastroenterology (1982) [Pubmed]
  20. Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats. Higgs, R.H., Castell, D.O., Eastwood, G.L. Gastroenterology (1976) [Pubmed]
  21. Inhibition of gastric emptying is a physiological action of cholecystokinin. Debas, H.T., Farooq, O., Grossman, M.I. Gastroenterology (1975) [Pubmed]
  22. Pentagastrin stimulates epithelial cell proliferation in duodenal and colonic crypts in fasted rats. Mak, K.M., Chang, W.W. Gastroenterology (1976) [Pubmed]
  23. Effects of fundic distention on pentagastrin-stimulated gastric acid secretion in man. Grötzinger, U., Bergegårdh, S., Olbe, L. Gastroenterology (1977) [Pubmed]
  24. Local control of canine gastric mucosal blood flow. Kiel, J.W., Riedel, G.L., Shepherd, A.P. Gastroenterology (1987) [Pubmed]
  25. Trophic effect of pentagastrin on normal and regenerating parietal cells. A light and electron microscopic study in rats. Blom, H., Erikoinen, T. Gastroenterology (1984) [Pubmed]
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  27. Corticotropin-releasing factor. Mechanisms to inhibit gastric acid secretion in conscious dogs. Lenz, H.J., Hester, S.E., Brown, M.R. J. Clin. Invest. (1985) [Pubmed]
  28. Functioning heterotopic oxyntic mucosa in the rectum. Debas, H.T., Chaun, H., Thomson, F.B., Soon-Shiong, P. Gastroenterology (1980) [Pubmed]
  29. Histamine metabolism in human gastric mucosa. Effect of pentagastrin stimulation. Lönroth, H., Rosengren, E., Olbe, L., Lundell, L. Gastroenterology (1990) [Pubmed]
  30. Additive interaction of pentagastrin and secretin on pancreatic growth in rats. Solomon, T.E., Morisset, J., Wood, J.G., Bussjaeger, L.J. Gastroenterology (1987) [Pubmed]
  31. Enterogastrone-like effect of peptide YY is vagally mediated in the dog. Pappas, T.N., Debas, H.T., Taylor, I.L. J. Clin. Invest. (1986) [Pubmed]
  32. Natural history and morphology of secretagogue-induced duodenal ulcers in rats. Gaskin, R.J., Gad, A., Barros D'sa, A.A., Joffe, S.N., Baron, J.H. Gastroenterology (1975) [Pubmed]
  33. Gastric epithelial restitution at low luminal pH during influence of pentagastrin or cimetidine in the cat. Grönbech, J.E., Grong, K., Varhaug, J.E., Lekven, J., Svanes, K. Gastroenterology (1987) [Pubmed]
  34. Omeprazole induces high intraglandular pressure in the rat gastric mucosa. Synnerstad, I., Holm, L. Gastroenterology (1997) [Pubmed]
  35. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Martinez, V., Curi, A.P., Torkian, B., Schaeffer, J.M., Wilkinson, H.A., Walsh, J.H., Taché, Y. Gastroenterology (1998) [Pubmed]
  36. Evidence for an involvement of the brain cholecystokinin B receptor in anxiety. Singh, L., Lewis, A.S., Field, M.J., Hughes, J., Woodruff, G.N. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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  38. Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms. Marshall, F.H., Barnes, S., Hughes, J., Woodruff, G.N., Hunter, J.C. J. Neurochem. (1991) [Pubmed]
  39. Influence of desalivation on acid secretory output and gastric mucosal integrity in the rat. Skinner, K.A., Tepperman, B.L. Gastroenterology (1981) [Pubmed]
  40. Control of the interdigestive myoelectric activity in dogs by the vagus nerves and pentagastrin. Marik, F., Code, C.F. Gastroenterology (1975) [Pubmed]
  41. Effect of antibodies to somatostatin on acid secretion and gastrin release by the isolated perfused rat stomach. Short, G.M., Doyle, J.W., Wolfe, M.M. Gastroenterology (1985) [Pubmed]
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