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Chemical Compound Review

Melaleucol     4-methyl-1-propan-2-yl- cyclohex-3-en-1-ol

Synonyms: Terpinenolu-4, Terpinenol-4, Terpineol-4, TERPINENE-4-OL, dl-4-Terpineol, ...
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Disease relevance of NSC 147749


High impact information on NSC 147749


Chemical compound and disease context of NSC 147749


Biological context of NSC 147749

  • In this study two major constituents of Tea Tree oil, 1,8-cineole and terpinen-4-ol, were shown to inhibit acetylcholinesterase at IC50 values (inhibitor concentrations required to give 50% inhibition) of 0.04 and 10.30 mM, respectively [9].
  • The aim of this study was to investigate skin absorption and elimination kinetics of two terpenes, namely linalool and terpinen-4-ol, incorporated in three different dermatological vehicles: oily solution, hydrogel and o/w emulsion [10].

Anatomical context of NSC 147749


Associations of NSC 147749 with other chemical compounds


Analytical, diagnostic and therapeutic context of NSC 147749


  1. Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. Calcabrini, A., Stringaro, A., Toccacieli, L., Meschini, S., Marra, M., Colone, M., Salvatore, G., Mondello, F., Arancia, G., Molinari, A. J. Invest. Dermatol. (2004) [Pubmed]
  2. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Carson, C.F., Mee, B.J., Riley, T.V. Antimicrob. Agents Chemother. (2002) [Pubmed]
  3. Susceptibility of pseudomonads to Melaleuca alternifolia (tea tree) oil and components. Papadopoulos, C.J., Carson, C.F., Hammer, K.A., Riley, T.V. J. Antimicrob. Chemother. (2006) [Pubmed]
  4. Growth-inhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria. Kim, H.G., Cho, J.H., Jeong, E.Y., Lim, J.H., Lee, S.H., Lee, H.S. J. Food Prot. (2006) [Pubmed]
  5. Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response. Brand, C., Grimbaldeston, M.A., Gamble, J.R., Drew, J., Finlay-Jones, J.J., Hart, P.H. Inflamm. Res. (2002) [Pubmed]
  6. Skin penetration of terpenes from essential oils and topical vehicles. Cal, K. Planta Med. (2006) [Pubmed]
  7. Cardiovascular effects of the essential oil of Alpinia zerumbet leaves and its main constituent, Terpinen-4-ol, in rats: role of the autonomic nervous system. Lahlou, S., Galindo, C.A., Leal-Cardoso, J.H., Fonteles, M.C., Duarte, G.P. Planta Med. (2002) [Pubmed]
  8. Isolation and partial characterisation of a putative monoterpene synthase from Melaleuca alternifolia. Shelton, D., Zabaras, D., Chohan, S., Wyllie, S.G., Baverstock, P., Leach, D., Henry, R. Plant Physiol. Biochem. (2004) [Pubmed]
  9. Inhibition of acetylcholinesterase by Tea Tree oil. Mills, C., Cleary, B.J., Gilmer, J.F., Walsh, J.J. J. Pharm. Pharmacol. (2004) [Pubmed]
  10. How does the type of vehicle influence the in vitro skin absorption and elimination kinetics of terpenes? Cal, K. Arch. Dermatol. Res. (2006) [Pubmed]
  11. Terpinen-4-ol: mechanisms of relaxation on rabbit duodenum. Nascimento, N.R., Leal-Cardoso, J.H., Lessa, L.M., Roriz-Filho, J.S., Cunha, K.M., Fonteles, M.C. J. Pharm. Pharmacol. (2005) [Pubmed]
  12. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Hart, P.H., Brand, C., Carson, C.F., Riley, T.V., Prager, R.H., Finlay-Jones, J.J. Inflamm. Res. (2000) [Pubmed]
  13. Effect of physicochemical properties of cyclic terpenes on their ex vivo skin absorption and elimination kinetics. Cal, K., Kupiec, K., Sznitowska, M. J. Dermatol. Sci. (2006) [Pubmed]
  14. Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica. Matsunaga, T., Hasegawa, C., Kawasuji, T., Suzuki, H., Saito, H., Sagioka, T., Takahashi, R., Tsukamoto, H., Morikawa, T., Akiyama, T. Biol. Pharm. Bull. (2000) [Pubmed]
  15. Terpene-enhanced transdermal permeation of water and ethanol in human epidermis. Magnusson, B.M., Runn, P., Koskinen, L.O. Acta Derm. Venereol. (1997) [Pubmed]
  16. Anticonflict effects of lavender oil and identification of its active constituents. Umezu, T., Nagano, K., Ito, H., Kosakai, K., Sakaniwa, M., Morita, M. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  17. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Lahlou, S., Interaminense, L.F., Leal-Cardoso, J.H., Duarte, G.P. Fundamental & clinical pharmacology. (2003) [Pubmed]
  18. Discrimination between the enantiomers of carvone and of terpinen-4-ol odorants in normal rats and those with lesions of the olfactory bulbs. McBride, K., Slotnick, B. J. Neurosci. (2006) [Pubmed]
  19. Tea tree oil concentration in follicular casts after topical delivery: determination by high-performance thin layer chromatography using a perfused bovine udder model. Biju, S.S., Ahuja, A., Khar, R.K. Journal of pharmaceutical sciences. (2005) [Pubmed]
  20. Interactions between components of the essential oil of Melaleuca alternifolia. Cox, S.D., Mann, C.M., Markham, J.L. J. Appl. Microbiol. (2001) [Pubmed]
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