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Chemical Compound Review:

zlchem 211 pyridin-4-ylmethanol

Synonyms: PubChem11738, AGN-PC-0DBETE, SureCN102606, AG-G-07859, ACMC-209m6i, ...

Mdluli, K. et al., DeBarber, A.E. et al., Cosgriff, T.M. et al.

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Disease relevance of pyridin-4-ylmethanol

We measured the rate of conversion of radiolabelled INH to 4-pyridylmethanol by whole cells and cell-free extracts and estimated the permeability barrier imposed by the cell wall to INH influx in Mycobacterium tuberculosis and M. avium [1].

High impact information on pyridin-4-ylmethanol

ETA is metabolized by MTb to a 4-pyridylmethanol product remarkably similar in structure to that formed by the activation of isoniazid by the catalase-peroxidase KatG [2].
Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects [3].

References

Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium. Mdluli, K., Swanson, J., Fischer, E., Lee, R.E., Barry, C.E. Mol. Microbiol. (1998) [Pubmed]
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. DeBarber, A.E., Mdluli, K., Bosman, M., Bekker, L.G., Barry, C.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects. Cosgriff, T.M., Boudreau, E.F., Pamplin, C.L., Berman, J.D., Shmuklarsky, M.J., Canfield, C.J. Am. J. Trop. Med. Hyg. (1984) [Pubmed]

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