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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Peramine     2-[3-(4-methyl-5-oxo-1,4...

Synonyms: AC1L3FW5, 102482-94-0
 
 
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High impact information on Peramine

  • Candidate sequences for a peramine synthetase were amplified by reverse transcription polymerase chain reaction [1].
  • The relationships of the distributions of the insect and mammalian mycotoxins, lolitrem B and ergovaline, and the insect-feeding deterrent, peramine, with the distribution of fungal mycelium were investigated in three genotypes of perennial ryegrass (Lolium perenne L.) infected with the endophyte Neotyphodium lolii [2].
  • Variation in the tissue distribution of the endophyte accounted only for 20%, 6%, and 31% of the variation in ergovaline, lolitrem B, and peramine, respectively [2].
  • The results suggest that whereas the endophyte is required for peramine production, the plant genotypic background in which the endophyte is embedded, rather than endophyte haplotype or environmental factors, mostly influences peramine levels within this population of Arizona fescue [3].
 

Biological context of Peramine

  • Peramine alkaloid variation in Neotyphodium-infected Arizona fescue: effects of endophyte and host genotype and environment [3].
  • Simplified extraction of ergovaline and peramine for analysis of tissue distribution in endophyte-infected grass tillers [4].
 

Analytical, diagnostic and therapeutic context of Peramine

  • In a choice bioassay, plant material containing the perA mutant was as susceptible to Argentine stem weevil (ASW) (Listronotus bonariensis) feeding damage as endophyte-free plants confirming that peramine is the E. festucae metabolite responsible for ASW feeding deterrent activity [1].
  • No lolitrems (the indole-diterpenoids implicated as the causative agents of perennial ryegrass staggers), peramine analogs, or ergot alkaloids were detected in the infected specimens by high-performance liquid chromatography or ELISA [5].

References

  1. A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory. Tanaka, A., Tapper, B.A., Popay, A., Parker, E.J., Scott, B. Mol. Microbiol. (2005) [Pubmed]
  2. Distribution of the fungal endophyte Neotyphodium lolii is not a major determinant of the distribution of fungal alkaloids in Lolium perenne plants. Spiering, M.J., Lane, G.A., Christensen, M.J., Schmid, J. Phytochemistry (2005) [Pubmed]
  3. Peramine alkaloid variation in Neotyphodium-infected Arizona fescue: effects of endophyte and host genotype and environment. Faeth, S.H., Bush, L.P., Sullivan, T.J. J. Chem. Ecol. (2002) [Pubmed]
  4. Simplified extraction of ergovaline and peramine for analysis of tissue distribution in endophyte-infected grass tillers. Spiering, M.J., Davies, E., Tapper, B.A., Schmid, J., Lane, G.A. J. Agric. Food Chem. (2002) [Pubmed]
  5. Endophytic fungi in indigenous Australasian grasses associated with toxicity to livestock. Miles, C.O., di Menna, M.E., Jacobs, S.W., Garthwaite, I., Lane, G.A., Prestidge, R.A., Marshall, S.L., Wilkinson, H.H., Schardl, C.L., Ball, O.J., Latch, G.C. Appl. Environ. Microbiol. (1998) [Pubmed]
 
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