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Chemical Compound Review:

AG-G-20356 2-amino-3-oxo-phenoxazine- 1,9-dicarboxylic...

Synonyms: CHEMBL2322655, HMDB04078, SureCN11888793, BCPP000278, CTK2F4342, ...

Christen, S. et al., Ogawa, H. et al., Nagamura, Y. et al., Manthey, M.K. et al., Eggert, C.

Nagamura, Uesugi, Naito, Ishiguro,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on C05640

A product versus time study of this reaction has revealed that, in the absence of catalase, cinnabarinic acid is formed but undergoes decomposition by hydrogen peroxide [1].

High impact information on C05640

In contrast, addition of 3-hydroxyanthranilic acid to human erythrocytes resulted in only marginal formation of cinnabarinic acid [2].
Thus, interferon-gamma-treated human peripheral blood mononuclear cells formed and released significant amounts of 3-hydroxyanthranilic acid into the culture medium and mouse liver nuclear fraction possessed high "cinnabarinic acid synthase" activity [2].
3-Hydroxyanthranilic acid may be oxidized to cinnabarinic acid by injured mitochondria in the liver aggravating the state of injured liver [3].
The biological activity of concentrated P. cinnabarinus culture fluid was nearly identical with that of cinnabarinic acid, synthesized by purified laccase in vitro [4].
These findings suggest that in Malpighian tubules catalase participates in the formation of cinnabarinic acid [5].

Anatomical context of C05640

Cinnabarinic acid was formed in damaged mitochondria and its effect on mitochondrial respiration [3].

Associations of C05640 with other chemical compounds

Cinnabarinic acid formation in Malpighian tubules of the silkworm, Bombyx mori. Participation of catalase in cinnabarinic acid formation in the presence of manganese ion [5].

Analytical, diagnostic and therapeutic context of C05640

Simultaneous determination of 3-hydroxyanthranilic and cinnabarinic acid by high-performance liquid chromatography with photometric or electrochemical detection [2].

References

Mechanism of reaction of 3-hydroxyanthranilic acid with molecular oxygen. Manthey, M.K., Pyne, S.G., Truscott, R.J. Biochim. Biophys. Acta (1990) [Pubmed]
Simultaneous determination of 3-hydroxyanthranilic and cinnabarinic acid by high-performance liquid chromatography with photometric or electrochemical detection. Christen, S., Stocker, R. Anal. Biochem. (1992) [Pubmed]
Cinnabarinic acid was formed in damaged mitochondria and its effect on mitochondrial respiration. Nagamura, Y., Uesugi, K., Naito, J., Ishiguro, I. Adv. Exp. Med. Biol. (1999) [Pubmed]
Laccase-catalyzed formation of cinnabarinic acid is responsible for antibacterial activity of Pycnoporus cinnabarinus. Eggert, C. Microbiol. Res. (1997) [Pubmed]
Cinnabarinic acid formation in Malpighian tubules of the silkworm, Bombyx mori. Participation of catalase in cinnabarinic acid formation in the presence of manganese ion. Ogawa, H., Nagamura, Y., Ishiguro, I. Hoppe-Seyler's Z. Physiol. Chem. (1983) [Pubmed]

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