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MeSH Review

Time and Motion Studies

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Disease relevance of Time and Motion Studies


High impact information on Time and Motion Studies

  • In PHT gastric mucosa, MKP-1 mRNA and protein expression were increased at baseline versus SO rats and were increased further following alcohol injury with values higher by 20%-40% at each study time versus SO rats [6].
  • The 10 d stress time studies indicate that increased IL-6 secretion is positively related to elevated iSP in the peritoneal wash fluid and inversely related to reduced iSP in certain peritoneum-containing tissues [7].
  • Each underwent a liquid gastric emptying study and a lactulose oral-cecal transit time study [8].
  • Time studies indicated that the response of the glomerular cells to high glucose occurs over an extended period (maximal at approximately 78 h) and, furthermore, that the stimulatory effect on type IV collagen production is only slowly reversed after restoration of the glucose to a normal level [9].
  • A time study indicated that allysine levels increased primarily after the bulk of Schiff base synthesis [10].

Chemical compound and disease context of Time and Motion Studies

  • Multi-region time and motion studies were conducted in hospitals of various sizes to determine the cost of personnel and supplies associated with the preparation, dispensing, and administration of reconstituted parenteral antibiotics [11].
  • Transit time studies were performed using 10 radiopaque markers [12].
  • A split dose thallium imaging technique that allows imaging before and immediately after exercise, thus markedly reducing the study time, has been validated [13].
  • Significant reductions versus placebo in 120-min postprandial insulin levels, in LDL cholesterol, and in fasting triglycerides, were also seen in the miglitol group at individual study time points [14].
  • This approach results in a large reduction in total study time of nearly 2 hours for carbon-11-labeled tracers [15].

Biological context of Time and Motion Studies


Anatomical context of Time and Motion Studies


Gene context of Time and Motion Studies

  • Plasma cholecystokinin and neurotensin after an ordinary meal in humans. A prolonged time study [23].
  • Time studies with IFN-gamma and LPS/silica demonstrated that enhanced production was time dependent and that IL-1 beta was primarily cell associated [24].
  • In a time study, IGF-I or IGF-II stimulated DNA synthesis 3-fold in 24 h [25].
  • These clotting time studies suggested that much of the anticoagulant effect caused by injection of heparin depended on EPI [26].
  • In a time study experiment we found that P450C11 transformed the labeled-steroid into [14C]corticosterone, [14C]19-OH-deoxycorticosterone and [14C]18-OH-deoxycorticosterone in ratios of 1:1.11:0.07, after 2 h of incubation; no [14C]aldosterone could be detected [27].

Analytical, diagnostic and therapeutic context of Time and Motion Studies

  • Within the 12-month observation time study patients with pTa G2 and pT1 G2 tumors showed a recurrence rate of 33%, comparable to that in a local historical control group of patients with equal stage and grade who were treated with adjuvant BCG [28].
  • METHODS: Segmental and total colonic transit time studies measured by means of radiopaque markers were conducted in 56 HD patients, 63 CAPD patients, and 25 healthy control subjects [29].
  • In time studies, pretreatment with cysteamine in a dose of 300 mg/kg (s.c.) led to markedly decreased hypothalamic noradrenaline contents 4 hr, 8 hr and 12 hr after treatment [30].


  1. Calcitonin gene-related peptide and substance P decrease in the rabbit colon during colitis. A time study. Eysselein, V.E., Reinshagen, M., Cominelli, F., Sternini, C., Davis, W., Patel, A., Nast, C.C., Bernstein, D., Anderson, K., Khan, H. Gastroenterology (1991) [Pubmed]
  2. The treatment of antiretroviral-naive subjects with the 3TC/zidovudine combination: a review of North American (NUCA 3001) and European (NUCB 3001) trials. Eron, J.J. AIDS (1996) [Pubmed]
  3. Nuclear magnetic resonance relaxation time studies on the manganese(II) ion complex with succinyl coenzyme A synthetase from Escherichia coli. Lam, Y.F., Bridger, W.A., Kotowycz, G. Biochemistry (1976) [Pubmed]
  4. Experimental acute pancreatitis: MR relaxation time studies using gadolinium-DTPA. Paajanen, H., Brasch, R.C., Dean, P.B. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1988) [Pubmed]
  5. Assessment of regional myocardial ischemia by positron-emission computed tomography. Schelbert, H.R., Henze, E., Phelps, M.E., Kuhl, D.E. Am. Heart J. (1982) [Pubmed]
  6. Portal hypertensive gastric mucosa has reduced activation of MAP kinase (ERK2) in response to alcohol injury: a key to impaired healing? Kawanaka, H., Tomikawa, M., Jones, M.K., Pai, R., Szabo, I.L., Sugimachi, K., Sarfeh, I.J., Tarnawski, A.S. FASEB J. (2001) [Pubmed]
  7. Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages. Zhu, G.F., Chancellor-Freeland, C., Berman, A.S., Kage, R., Leeman, S.E., Beller, D.I., Black, P.H. J. Neurosci. (1996) [Pubmed]
  8. Gastrointestinal transit in cirrhotic patients: effect of hepatic encephalopathy and its treatment. Van Thiel, D.H., Fagiuoli, S., Wright, H.I., Chien, M.C., Gavaler, J.S. Hepatology (1994) [Pubmed]
  9. Effect of high glucose on type IV collagen production by cultured glomerular epithelial, endothelial, and mesangial cells. Danne, T., Spiro, M.J., Spiro, R.G. Diabetes (1993) [Pubmed]
  10. Collagen cross-linking. Effect of D-penicillamine on cross-linking in vitro. Siegel, R.C. J. Biol. Chem. (1977) [Pubmed]
  11. Cost containment associated with decreased parenteral antibiotic administration frequencies. Tanner, D.J., Nazarian, M.Q. Am. J. Med. (1984) [Pubmed]
  12. Recovery of fasted and fed gastrointestinal motility after open versus laparoscopic cholecystectomy in dogs. Hotokezaka, M., Combs, M.J., Mentis, E.P., Schirmer, B.D. Ann. Surg. (1996) [Pubmed]
  13. Quantitative split dose thallium-201 imaging with exercise: a technique for obtaining rest and exercise perfusion images in one setting and markedly reducing the study time. Okada, R.D., Boucher, C.A., Pohost, G.M. J. Am. Coll. Cardiol. (1985) [Pubmed]
  14. Chronic treatment of African-American type 2 diabetic patients with alpha-glucosidase inhibition. Johnston, P.S., Feig, P.U., Coniff, R.F., Krol, A., Kelley, D.E., Mooradian, A.D. Diabetes Care (1998) [Pubmed]
  15. Dual-[11C]tracer single-acquisition positron emission tomography studies. Koeppe, R.A., Raffel, D.M., Snyder, S.E., Ficaro, E.P., Kilbourn, M.R., Kuhl, D.E. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  16. Quantitation of bovine TNF-alpha mRNA by reverse transcription and competitive polymerase chain reaction amplification. Bienhoff, S.E., Allen, G.K. Vet. Immunol. Immunopathol. (1995) [Pubmed]
  17. Cyclooxygenase-2--specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Whelton, A., Fort, J.G., Puma, J.A., Normandin, D., Bello, A.E., Verburg, K.M. American journal of therapeutics. (2001) [Pubmed]
  18. 31P NMR relaxation time studies of 2,3-diphosphoglycerate in solution and intact erythrocytes. Christensen, M., Jacobsen, J.P. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1988) [Pubmed]
  19. A time study of the effect of LH stimulation on cholesterol contents of rabbit ovarian follicles and the effect of indomethacin pretreatment on the response to LH. Patwardhan, V.V., Lanthier, A. Biol. Reprod. (1979) [Pubmed]
  20. Protection of the small intestinal clonogenic stem cells from radiation-induced damage by pretreatment with interleukin 11 also increases murine survival time. Potten, C.S. Stem Cells (1996) [Pubmed]
  21. Effects of drying time and the presence of plaque on the in vitro performance of laser fluorescence in occlusal caries of primary teeth. Mendes, F.M., Hissadomi, M., Imparato, J.C. Caries Res. (2004) [Pubmed]
  22. Effect of local injection with basic fibroblast growth factor (BFGF) and neutralizing antibody to BFGF on gastric ulcer healing, gastric secretion, angiogenesis and gastric blood flow. Ernst, H., Konturek, P.C., Hahn, E.G., Stosiek, H.P., Brzozowski, T., Konturek, S.J. J. Physiol. Pharmacol. (2001) [Pubmed]
  23. Plasma cholecystokinin and neurotensin after an ordinary meal in humans. A prolonged time study. Gullo, L., Pezzilli, R., Tomassetti, P., de Giorgio, R. Gastroenterol. Clin. Biol. (1998) [Pubmed]
  24. Interferon-gamma, Staphylococcus aureus, and lipopolysaccharide/silica enhance interleukin-1 beta production by human corneal cells. Shams, N.B., Sigel, M.M., Davis, R.M. Regional immunology. (1989) [Pubmed]
  25. Insulin-like growth factor binding protein-1 inhibits the mitogenic effect of insulin-like growth factors and progestins in human endometrial stromal cells. Frost, R.A., Mazella, J., Tseng, L. Biol. Reprod. (1993) [Pubmed]
  26. The anticoagulant effect in heparinized blood and plasma resulting from interactions with extrinsic pathway inhibitor. Lindahl, A.K., Abildgaard, U., Staalesen, R. Thromb. Res. (1991) [Pubmed]
  27. The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity. Véronneau, S., Bernard, H., Cloutier, M., Courtemanche, J., Ducharme, L., Lefebvre, A., Mason, J.I., LeHoux, J.G. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  28. Adjuvant intravesical treatment of superficial bladder cancer with a standardized mistletoe extract. Elsässer-Beile, U., Leiber, C., Wolf, P., Lucht, M., Mengs, U., Wetterauer, U. J. Urol. (2005) [Pubmed]
  29. Colonic transit time in long-term dialysis patients. Wu, M.J., Chang, C.S., Cheng, C.H., Chen, C.H., Lee, W.C., Hsu, Y.H., Shu, K.H., Tang, M.J. Am. J. Kidney Dis. (2004) [Pubmed]
  30. Selective decrease of hypothalamic noradrenaline by cysteamine. Vécsei, L., Balázs, M., Bollók, I., Telegdy, G. Archives internationales de pharmacodynamie et de thérapie. (1985) [Pubmed]
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