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Chemical Compound Review

CHEMBL51370     3-(2-chloroethyl)-2-(2- chloroethylamino)-1...

Synonyms: AC1L3GXH, LS-99826, CTK8D5708, AR-1E6179, AC1Q3V55, ...
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Disease relevance of 4-Hydroxyifosfamide


High impact information on 4-Hydroxyifosfamide


Biological context of 4-Hydroxyifosfamide

  • At concentrations of 4OHI similar to those determined in vivo, an equivalent level of DNA damage was observed in PBL and in cell lines and was associated with significant growth inhibition [7].
  • The bioavailability is nearly 100% after oral application, and the main metabolites are 4-hydroxytrofosfamide, and 4-hydroxyifosfamide [8].

Anatomical context of 4-Hydroxyifosfamide


Analytical, diagnostic and therapeutic context of 4-Hydroxyifosfamide


  1. Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma. Kerbusch, T., Mathĵt, R.A., Keizer, H.J., Ouwerkerk, J., Rodenhuis, S., Schellens, J.H., Beijnen, J.H. Eur. J. Clin. Pharmacol. (2001) [Pubmed]
  2. Differential effects of ifosfamide on the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels. Multhoff, G., Meier, T., Botzler, C., Wiesnet, M., Allenbacher, A., Wilmanns, W., Issels, R.D. Blood (1995) [Pubmed]
  3. Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma. Wiedemann, G.J., d'Oleire, F., Knop, E., Eleftheriadis, S., Bucsky, P., Feddersen, S., Klouche, M., Geisler, J., Mentzel, M., Schmucker, P. Cancer Res. (1994) [Pubmed]
  4. Effects of temperature on the therapeutic efficacy and pharmacokinetics of ifosfamide. Wiedemann, G.J., Siemens, H.J., Mentzel, M., Biersack, A., Wössmann, W., Knocks, D., Weiss, C., Wagner, T. Cancer Res. (1993) [Pubmed]
  5. Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin. Kerbusch, T., Jansen, R.L., Mathôt, R.A., Huitema, A.D., Jansen, M., van Rijswijk, R.E., Beijnen, J.H. Clin. Pharmacol. Ther. (2001) [Pubmed]
  6. Metabolism of ifosfamide to chloroacetaldehyde contributes to antitumor activity in vivo. Börner, K., Kisro, J., Brüggemann, S.K., Hagenah, W., Peters, S.O., Wagner, T. Drug Metab. Dispos. (2000) [Pubmed]
  7. Ifosfamide metabolism and DNA damage in tumour and peripheral blood lymphocytes of breast cancer patients. Johnstone, E.C., Lind, M.J., Griffin, M.J., Boddy, A.V. Cancer Chemother. Pharmacol. (2000) [Pubmed]
  8. Hypersensitivity pneumonitis associated with the use of trofosfamide. Kopp, H.G., Kanz, L., Hartmann, J.T. Anticancer Drugs (2004) [Pubmed]
  9. Pharmacokinetics of ifosfamide and some metabolites in children. Kaijser, G.P., De Kraker, J., Bult, A., Underberg, W.J., Beijnen, J.H. Anticancer Res. (1998) [Pubmed]
  10. High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes. Kerbusch, T., Huitema, A.D., Kettenes-van den Bosch, J.J., Keizer, H.J., Ouwerkerk, J., de Kraker, J., Beijnen, J.H. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
  11. Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography. Kaijser, G.P., Ter Riet, P.G., de Kraker, J., Bult, A., Beijnen, J.H., Underberg, W.J. Journal of pharmaceutical and biomedical analysis. (1997) [Pubmed]
  12. Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorus-selective detector. Gourmel, B., Granvil, C.P., Denis, S.L., Wainer, I.W., Bousquet, B. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]
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