Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-J-02379 4-amino-3-(1- carboxyethenoxy)cyclohexa- 1,5...

Synonyms: AC1Q5TCI, CTK3I8523, AR-1G0643, AC1L18II, 97279-79-3

Basset, G.J. et al., Chang, Z. et al., Parsons, J.F. et al.

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Disease relevance of 4-amino-4-deoxychorismate

In Escherichia coli, this step is catalyzed by the PabC protein, a beta-lyase that converts 4-amino-4-deoxychorismate (ADC)--the reaction product of the PabA and PabB enzymes--to PABA and pyruvate [1].
p-Aminobenzoic acid and chloramphenicol biosynthesis in Streptomyces venezuelae: gene sets for a key enzyme, 4-amino-4-deoxychorismate synthase [2].

High impact information on 4-amino-4-deoxychorismate

PhzD also catalyzes hydrolysis of the related vinyl ethers isochorismate, chorismate, and 4-amino-4-deoxychorismate [3].

References

Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase. Basset, G.J., Ravanel, S., Quinlivan, E.P., White, R., Giovannoni, J.J., Rébeillé, F., Nichols, B.P., Shinozaki, K., Seki, M., Gregory, J.F., Hanson, A.D. Plant J. (2004) [Pubmed]
p-Aminobenzoic acid and chloramphenicol biosynthesis in Streptomyces venezuelae: gene sets for a key enzyme, 4-amino-4-deoxychorismate synthase. Chang, Z., Sun, Y., He, J., Vining, L.C. Microbiology (Reading, Engl.) (2001) [Pubmed]
Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway. Parsons, J.F., Calabrese, K., Eisenstein, E., Ladner, J.E. Biochemistry (2003) [Pubmed]

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