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Chemical Compound Review

Hachemina     4-aminobenzoic acid

Synonyms: Pabafilm, Pabamine, Paraminol, Potaba, PABA, ...
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Disease relevance of Potaba


Psychiatry related information on Potaba


High impact information on Potaba


Chemical compound and disease context of Potaba


Biological context of Potaba

  • Isolation involved random mutagenesis of a cloned line of P. falciparum and subsequent selection of PABA-dependent parasites [14].
  • When the NAT1 genotype was compared with the NAT1 phenotype in bladder and colon tissue samples (p-aminobenzoic acid activity), we observed a approximately 2-fold higher NAT1 enzyme activity in samples from individuals who inherited a variant polyadenylation signal (NAT1*10 allele) [15].
  • Kinetics of the oxidation of p-aminobenzoic acid catalyzed by horseradish peroxidase compounds I and II [16].
  • We have investigated the effects of carcinogenic doses of UVB-irradiation, psoralen plus UVA light (PUVA), PABA containing sunscreen preparations, and topically applied corticosteroids on both Langerhans cell densities and immunologic responsiveness to contact sensitizers applied to the treated site [17].
  • Sex differences were apparent in this activity in C57BL/6J mouse kidney, with males exhibiting approximately 2.5-fold higher activity for aminofluorene and approximately 3-fold higher activity for p-aminobenzoic acid than did females [18].

Anatomical context of Potaba


Associations of Potaba with other chemical compounds


Gene context of Potaba

  • Moreover, the DNA adduct levels in these tissues correlated with their NAT1-dependent PABA activities (r = 0.52; P < 0.01) but not with their OAT activities [28].
  • In slow acetylators who have decreased levels of hepatic NAT2, the AFMU/1X ratio was significantly correlated with PABA acetylation in MNL (r = 0.8; p = 0.0002) [29].
  • A disruption of pabC was constructed and transferred to the chromosome, and the pabC mutant strain required PABA for growth [30].
  • However, expression analysis using chromosomal pabA-lacZ translational fusions indicated that P1 expressed PabA at least 50-fold more efficiently than P2. pabA-dependent growth rate analysis indicates that P1 is essential and P2 is dispensable for PABA metabolism [31].
  • The use of stronger promoters to drive FOL1 expression led to increased sulfamethoxazole resistance when para-aminobenzoic acid (pABA) levels were elevated [32].

Analytical, diagnostic and therapeutic context of Potaba


  1. The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal. Laufer, D., Cleghorn, G., Forstner, G., Ellis, L., Koren, G., Durie, P. Gastroenterology (1991) [Pubmed]
  2. Bentiromide test for assessing pancreatic dysfunction using analysis of para-aminobenzoic acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome. Weizman, Z., Forstner, G.G., Gaskin, K.J., Kopelman, H., Wong, S., Durie, P.R. Gastroenterology (1985) [Pubmed]
  3. Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids. Basset, G.J., Quinlivan, E.P., Ravanel, S., Rébeillé, F., Nichols, B.P., Shinozaki, K., Seki, M., Adams-Phillips, L.C., Giovannoni, J.J., Gregory, J.F., Hanson, A.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Serum PABA test in chronic pancreatitis. Bellentani, S., Grisendi, A., Manenti, F. Gut (1985) [Pubmed]
  5. Mouse monoclonal antibodies to chicken VH idiotypic determinants reactivity with B and T cells. Chanh, T.C., Chen, C.L., Cooper, M.D. J. Immunol. (1982) [Pubmed]
  6. p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors. Correa-Basurto, J., Alcántara, I.V., Espinoza-Fonseca, L.M., Trujillo-Ferrara, J.G. European journal of medicinal chemistry. (2005) [Pubmed]
  7. Exocrine pancreatic function in protein-deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test. Gyr, K., Wolf, R.H., Imondi, A.R., Felsenfeld, O. Gastroenterology (1975) [Pubmed]
  8. Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis. Díaz de la Garza, R., Quinlivan, E.P., Klaus, S.M., Basset, G.J., Gregory, J.F., Hanson, A.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Metabolism of procainamide and p-aminobenzoic acid in patients with chronic liver disease. du Souich, P., Erill, S. Clin. Pharmacol. Ther. (1977) [Pubmed]
  10. Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase. Basset, G.J., Ravanel, S., Quinlivan, E.P., White, R., Giovannoni, J.J., Rébeillé, F., Nichols, B.P., Shinozaki, K., Seki, M., Gregory, J.F., Hanson, A.D. Plant J. (2004) [Pubmed]
  11. Polymorphic N-acetylation of 2-aminofluorene by cell-free colon extracts from inbred mice. Levy, G.N., Martell, K.J., Weber, W.W. Pharmacogenetics (1993) [Pubmed]
  12. Para-aminobenzoic acid suppression of cis-diamminedichloroplatinum(II) nephrotoxicity. Esposito, M., Vannozzi, M.O., Viale, M., Fulco, R.A., Collecchi, P., Merlo, F., De Cian, F., Zicca, A., Cadoni, A., Poirier, M.C. Carcinogenesis (1993) [Pubmed]
  13. Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase. Walsh, C.T., Erion, M.D., Walts, A.E., Delany, J.J., Berchtold, G.A. Biochemistry (1987) [Pubmed]
  14. Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth. McConkey, G.A., Ittarat, I., Meshnick, S.R., McCutchan, T.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  15. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Bell, D.A., Badawi, A.F., Lang, N.P., Ilett, K.F., Kadlubar, F.F., Hirvonen, A. Cancer Res. (1995) [Pubmed]
  16. Kinetics of the oxidation of p-aminobenzoic acid catalyzed by horseradish peroxidase compounds I and II. Dunford, H.B., Cotton, M.L. J. Biol. Chem. (1975) [Pubmed]
  17. Relationship between epidermal Langerhans cell density ATPase activity and the induction of contact hypersensitivity. Lynch, D.H., Gurish, M.F., Daynes, R.A. J. Immunol. (1981) [Pubmed]
  18. Biochemical characterization of genetically variant aromatic amine N-acetyltransferases in A/J and C57BL/6J mice. Glowinski, I.B., Weber, W.W. J. Biol. Chem. (1982) [Pubmed]
  19. Oral administration of a chymotrypsin-labile peptide--a new test of exocrine pancreatic function in man (PFT). Gyr, K., Stalder, G.A., Schiffmann, I., Fehr, C., Vonderschmitt, D., Fahrlaender, H. Gut (1976) [Pubmed]
  20. Immunological evidence for N-acetyltransferase isozymes in the rabbit. Reeves, P.T., Kinnear, B.F., Minchin, R.F., Ilett, K.F. Mol. Pharmacol. (1991) [Pubmed]
  21. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Findlay, V.J., Townsend, D.M., Saavedra, J.E., Buzard, G.S., Citro, M.L., Keefer, L.K., Ji, X., Tew, K.D. Mol. Pharmacol. (2004) [Pubmed]
  22. Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. Butcher, N.J., Ilett, K.F., Minchin, R.F. Mol. Pharmacol. (2000) [Pubmed]
  23. Aminobenzoic acid compounds as HOCl traps for activated neutrophils. She, Z.W., Mays, D.C., Sagone, A.L., Davis, W.B. Free Radic. Biol. Med. (1997) [Pubmed]
  24. IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization. Mason, J.M., Naidu, M.D., Barcia, M., Porti, D., Chavan, S.S., Chu, C.C. J. Immunol. (2004) [Pubmed]
  25. Absorption spectra of radicals of substrates for p-hydroxybenzoate hydroxylase following electrophilic attack of the .OH radical in the 3 position. Anderson, R.F., Patel, K.B., Stratford, M.R. J. Biol. Chem. (1987) [Pubmed]
  26. Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products. Martell, K.J., Levy, G.N., Weber, W.W. Mol. Pharmacol. (1992) [Pubmed]
  27. Biotransformation of para-aminobenzoic acid and salicylic acid by PMN. Sagone, A.L., Husney, R.M., Davis, W.B. Free Radic. Biol. Med. (1993) [Pubmed]
  28. Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. Badawi, A.F., Hirvonen, A., Bell, D.A., Lang, N.P., Kadlubar, F.F. Cancer Res. (1995) [Pubmed]
  29. Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity. Cribb, A.E., Isbrucker, R., Levatte, T., Tsui, B., Gillespie, C.T., Renton, K.W. Pharmacogenetics (1994) [Pubmed]
  30. Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. Green, J.M., Merkel, W.K., Nichols, B.P. J. Bacteriol. (1992) [Pubmed]
  31. Chromosomal organization and expression of Escherichia coli pabA. Tran, P.V., Bannor, T.A., Doktor, S.Z., Nichols, B.P. J. Bacteriol. (1990) [Pubmed]
  32. Promoter strength of folic acid synthesis genes affects sulfa drug resistance in Saccharomyces cerevisiae. Iliades, P., Berglez, J., Meshnick, S., Macreadie, I. Microb. Drug Resist. (2003) [Pubmed]
  33. Sunlight suppressing rejection of 280- to 320-nm UV-radiation-induced skin tumors in mice. Morison, W.L., Kelley, S.P. J. Natl. Cancer Inst. (1985) [Pubmed]
  34. Reversibility of exocrine pancreatic failure in chronic pancreatitis. García-Pugés, A.M., Navarro, S., Ros, E., Elena, M., Ballesta, A., Aused, R., Vilar-Bonet, J. Gastroenterology (1986) [Pubmed]
  35. Use of the conjugate of disulphated ursodeoxycholic acid with p-aminobenzoic acid for the detection of intestinal bacteria. Takahashi, M., Konishi, T., Maeda, Y., Matsugu, Y., Akazawa, F., Eto, T., Okajima, M., Uchida, K., Masaoka, Y., Okada, K. Gut (1993) [Pubmed]
  36. Progressive loss of pancreatic function in chronic pancreatitis is delayed by main pancreatic duct decompression. A longitudinal prospective analysis of the modified puestow procedure. Nealon, W.H., Thompson, J.C. Ann. Surg. (1993) [Pubmed]
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