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Chemical Compound Review:

CCRIS 7176 dimethylmercury

Synonyms: AG-L-17982, CHEBI:30786, LS-89764, CTK1H0412, AKOS015916085, ...

Musiek, F.E. et al., Betti, C. et al., Shinyashiki, M. et al., Blayney, M.B., Nierenberg, D.W. et al.

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Disease relevance of dimethylmercury

Delayed cerebellar disease and death after accidental exposure to dimethylmercury [1].
OBJECTIVE: The audiological examination of this patient was to determine the degree and type of hearing loss that was incurred from apparent dimethylmercury poisoning [2].
Wetterhahn died from mercury poisoning resulting from a single exposure to dimethylmercury almost a year before [3].

High impact information on dimethylmercury

In contrast to the in vivo observation, inorganic-, alkyl-, and aryl-mercuric compound showed potent inhibition of nNOS activity with IC50 values of 11-43 microM, whereas dimethylmercury (DMM) was without effect on the enzyme activity [4].
Human lymphocytes (HL) as well as lymphocytes (RL), hepatocytes (RH), and gastric mucosa cells (GM) of Sprague-Dawley rats were treated in vitro for 1 h with methylmercury chloride (MMC, 0.5-4 micrograms/ml) and dimethylmercury (DMM, 5-40 micrograms/ml) [5].
CONCLUSION: Dimethylmercury poisoning, in this case, resulted in compromise of the auditory neural system with little effect on the sensory (cochlea) mechanism [2].

References

Delayed cerebellar disease and death after accidental exposure to dimethylmercury. Nierenberg, D.W., Nordgren, R.E., Chang, M.B., Siegler, R.W., Blayney, M.B., Hochberg, F., Toribara, T.Y., Cernichiari, E., Clarkson, T. N. Engl. J. Med. (1998) [Pubmed]
Neuroaudiological effects in a case of fatal dimethylmercury poisoning. Musiek, F.E., Hanlon, D.P. Ear and hearing. (1999) [Pubmed]
The need for empirically derived permeation data for personal protective equipment: the death of Dr. Karen E. Wetterhahn. Blayney, M.B. Applied occupational and environmental hygiene. (2001) [Pubmed]
Differential changes in rat brain nitric oxide synthase in vivo and in vitro by methylmercury. Shinyashiki, M., Kumagai, Y., Nakajima, H., Nagafune, J., Homma-Takeda, S., Sagai, M., Shimojo, N. Brain Res. (1998) [Pubmed]
Comparative studies on cytotoxic and genotoxic effects of two organic mercury compounds in lymphocytes and gastric mucosa cells of Sprague-Dawley rats. Betti, C., Barale, R., Pool-Zobel, B.L. Environ. Mol. Mutagen. (1993) [Pubmed]

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