Disease relevance of Mercury Poisoning

• The outbreak of Minamata disease (methyl mercury poisoning) in cats on Northwestern Ontario reserves [1].
• Repeated cutaneous application of yellow mercuric oxide ointment for infected eczema resulted in mercury poisoning in a 4-month-old infant [2].
• Iatrogenic neonatal mercury poisoning from Mercurochrome treatment of a large omphalocele [3].
• Our investigation shows a clear relation between methylmercury contamination and cytogenetic damage in lymphocytes at levels well below 50 micrograms/gram, the level at which initial clinical signs and symptoms of mercury poisoning occur [4].

High impact information on Mercury Poisoning

• Historians have suggested that US president Andrew Jackson (1767-1845) experienced lead and mercury poisoning following his therapeutic use of calomel (mercurous chloride) and sugar of lead (lead acetate) [5].
• Mercury poisoning from home gold ore processing. Use of penicillamine and dimercaprol [6].
• Less mercury was accumulated in the tissues with methyl mercury poisoning than in the other treatments [7].
• Clinical chelation therapy of mercury poisoning generally uses one or both of two drugs--meso-dimercaptosuccinic acid (DMSA) and dimercaptopropanesulfonic acid (DMPS), commercially sold as Chemet and Dimaval, respectively [8].
• DMSA administration to patients with alleged mercury poisoning from dental amalgams: a placebo-controlled study [9].

Chemical compound and disease context of Mercury Poisoning

• Acute mercury poisoning after polyvinyl alcohol preservative ingestion [10].
• The water-soluble dithiol chelating agents meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) are becoming of increasing importance for the treatment of lead, arsenic and mercury poisoning [11].
• The effects of glutathione glycoside in methyl mercury poisoning [12].
• Potentiation of acetaminophen hepatotoxicity in a child with mercury poisoning [13].
• Chelation of mercury by polymercaptal microspheres: new potential antidote for mercury poisoning [14].

Biological context of Mercury Poisoning

• Thirty cases of Minamata disease caused by methyl mercury poisoning with the lesion mainly at the occipital cortex were selected and their spatial contrast sensitivity of vision was examined by the Arden grating chart [15].
• Whereas known causative factors range from gold or mercury poisoning to autoimmune disorders, the presented case is the first one in which chronic manganese intoxication (occupational exposure) seems to be implicated [16].
• Minamata disease is a relatively new disease entity secondary to an environmental pollution, methyl mercury poisoning [17].

Anatomical context of Mercury Poisoning

• Influence of chronic mercury poisoning upon the connective tissue in rats. I. Effect of mercuric chloride on glycosaminoglycan levels in tissues, serum and urine [18].

Gene context of Mercury Poisoning

• Experiments in vivo have shown that DMSA is a better mercurial chelator than Thiola or MSA, whereas DDC and BAL may both be considered to be inapplicable in methyl mercury poisonings [19].
• Hemoperfusion for detoxification of mercury. A model:treatment of severe mercury poisoning by encapsulated chelating spheres, Part I [20].
• Influence of chronic mercury poisoning upon the connective tissue in rats. II. Effect of mercuric chloride on collagen and elastin [21].

References