Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL270516 2-[[(4R)-4-[ (3R,5S,6S,8S,9S,10R,13R,14S...

Synonyms: CCRIS 6480, AR-1D7254, LS-188289, FT-0674817, AC1L3O3W, ...

Loria, P. et al., Paolini, M. et al., Tripodi, A.S. et al., Paolini, M. et al., Tripodi, A.S. et al., et al.

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Disease relevance of CCRIS 6480

BACKGROUND: To clarify the preventive effect of taurohyodeoxycholic acid on liver cholestasis induced by toxic bile acids in rats, we evaluated whether modulation of cytochrome P4503A-linked oxidases is involved in the hepatic bile acid retention and secretion mechanism [1].
Reproductive toxicity of taurohyodeoxycholic acid [2].

High impact information on CCRIS 6480

Results on the most affected isoenzymes, CYP3A1/2 (THDCA, TUDCA, and UDCA) and CYP2E1 (UDCA), were sustained by means of Western immunoblotting [3].
In this study we investigated the anticholelithogenic and choleretic activities and the general pharmacological action of taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), a new biliary acid advocated for use as anticholelithogenic agent [4].
The mutagenicity of a new biliary acid, taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), was assayed by using 5 different tests [5].

Associations of CCRIS 6480 with other chemical compounds

In both taurohyodeoxycholic acid- and tauroursodeoxycholic acid-rich bile, 80% to 90% of cholesterol was carried in a gel-chromatographic fraction corresponding to an apparent molecular weight of 80 to 200 kd [6].

Analytical, diagnostic and therapeutic context of CCRIS 6480

No alteration in liver function test results was observed after taurohyodeoxycholic acid infusion [6].

References

Mechanism for the prevention of cholestasis involving cytochrome P4503A overexpression. Paolini, M., Pozzetti, L., Piazza, F., Guerra, M.C., Speroni, E., Cantelli-Forti, G., Roda, A. J. Investig. Med. (2000) [Pubmed]
Reproductive toxicity of taurohyodeoxycholic acid. Feletti, F., Tripodi, A.S., Germogli, R. Arzneimittel-Forschung. (1993) [Pubmed]
Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Paolini, M., Pozzetti, L., Piazza, F., Cantelli-Forti, G., Roda, A. Hepatology (1999) [Pubmed]
Pharmacological studies on taurohyodeoxycholic acid. Tripodi, A.S., Contos, S., Germogli, R. Arzneimittel-Forschung. (1993) [Pubmed]
In vitro and in vivo mutagenicity studies on taurohyodeoxycholic acid. Tripodi, A.S., Feletti, F., Molteni, R., Germogli, R. Arzneimittel-Forschung. (1993) [Pubmed]
Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. Loria, P., Bozzoli, M., Concari, M., Guicciardi, M.E., Carubbi, F., Bertolotti, M., Piani, D., Nistri, A., Angelico, M., Romani, M., Carulli, N. Hepatology (1997) [Pubmed]

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