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Chemical Compound Review

LS-65652     2-[[(4R)-4- [(3R,5S,7S,10S,13R,17R)- 3,7...

Synonyms: UR 906, Ursodeoxycholyltaurine, Tauroursodeoxycholic acid, Tauroursodeoxycholic acid (6CI,7CI)
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Disease relevance of Ursodeoxycholyltaurine


Psychiatry related information on Ursodeoxycholyltaurine


High impact information on Ursodeoxycholyltaurine


Chemical compound and disease context of Ursodeoxycholyltaurine


Biological context of Ursodeoxycholyltaurine


Anatomical context of Ursodeoxycholyltaurine


Associations of Ursodeoxycholyltaurine with other chemical compounds


Gene context of Ursodeoxycholyltaurine


Analytical, diagnostic and therapeutic context of Ursodeoxycholyltaurine


  1. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. Beuers, U., Nathanson, M.H., Isales, C.M., Boyer, J.L. J. Clin. Invest. (1993) [Pubmed]
  2. Negative feedback regulation of the ileal bile acid transport system in rodents. Lillienau, J., Crombie, D.L., Munoz, J., Longmire-Cook, S.J., Hagey, L.R., Hofmann, A.F. Gastroenterology (1993) [Pubmed]
  3. Vasoactive effects of bile salts in cirrhotic rats: in vivo and in vitro studies. Pak, J.M., Lee, S.S. Hepatology (1993) [Pubmed]
  4. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. Roda, A., Piazza, F., Baraldini, M., Speroni, E., Guerra, M.C., Cerré, C., Cantelli Forti, G. Hepatology (1998) [Pubmed]
  5. Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis. Setchell, K.D., Rodrigues, C.M., Podda, M., Crosignani, A. Gut (1996) [Pubmed]
  6. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Keene, C.D., Rodrigues, C.M., Eich, T., Chhabra, M.S., Steer, C.J., Low, W.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. Ramalho, R.M., Borralho, P.M., Castro, R.E., Solá, S., Steer, C.J., Rodrigues, C.M. J. Neurochem. (2006) [Pubmed]
  8. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Beuers, U., Throckmorton, D.C., Anderson, M.S., Isales, C.M., Thasler, W., Kullak-Ublick, G.A., Sauter, G., Koebe, H.G., Paumgartner, G., Boyer, J.L. Gastroenterology (1996) [Pubmed]
  9. Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate. Rodrigues, C.M., Kren, B.T., Steer, C.J., Setchell, K.D. Gastroenterology (1995) [Pubmed]
  10. Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Rodrigues, C.M., Sola, S., Nan, Z., Castro, R.E., Ribeiro, P.S., Low, W.C., Steer, C.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. Ishigami, F., Naka, S., Takeshita, K., Kurumi, Y., Hanasawa, K., Tani, T. Transplantation (2001) [Pubmed]
  12. Hepatoprotection in ethinylestradiol-treated rats is provided by tauroursodeoxycholic acid, but not by ursodeoxycholic acid. Azer, S.A., Canfield, P.J., Stacey, N.H. J. Gastroenterol. Hepatol. (1995) [Pubmed]
  13. Toxicity of ethanol and acetaldehyde in hepatocytes treated with ursodeoxycholic or tauroursodeoxycholic acid. Henzel, K., Thorborg, C., Hofmann, M., Zimmer, G., Leuschner, U. Biochim. Biophys. Acta (2004) [Pubmed]
  14. Neuroprotection by a bile acid in an acute stroke model in the rat. Rodrigues, C.M., Spellman, S.R., Solá, S., Grande, A.W., Linehan-Stieers, C., Low, W.C., Steer, C.J. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  15. Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? Calmus, Y., Podevin, P. Transplantation (2001) [Pubmed]
  16. Effects of bile acids on the muscle functions of guinea pig gallbladder. Xiao, Z.L., Rho, A.K., Biancani, P., Behar, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  17. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Benz, C., Angermüller, S., Otto, G., Sauer, P., Stremmel, W., Stiehl, A. Eur. J. Clin. Invest. (2000) [Pubmed]
  18. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Beuers, U., Bilzer, M., Chittattu, A., Kullak-Ublick, G.A., Keppler, D., Paumgartner, G., Dombrowski, F. Hepatology (2001) [Pubmed]
  19. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Xie, Q., Khaoustov, V.I., Chung, C.C., Sohn, J., Krishnan, B., Lewis, D.E., Yoffe, B. Hepatology (2002) [Pubmed]
  20. Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. Marzioni, M., Francis, H., Benedetti, A., Ueno, Y., Fava, G., Venter, J., Reichenbach, R., Mancino, M.G., Summers, R., Alpini, G., Glaser, S. Am. J. Pathol. (2006) [Pubmed]
  21. Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. Falasca, L., Tisone, G., Palmieri, G., Anselmo, A., Di Paolo, D., Baiocchi, L., Torri, E., Orlando, G., Casciani, C.U., Angelico, M. Transplantation (2001) [Pubmed]
  22. Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Beuers, U., Nathanson, M.H., Boyer, J.L. Gastroenterology (1993) [Pubmed]
  23. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Schoemaker, M.H., Conde de la Rosa, L., Buist-Homan, M., Vrenken, T.E., Havinga, R., Poelstra, K., Haisma, H.J., Jansen, P.L., Moshage, H. Hepatology (2004) [Pubmed]
  24. Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes. Paolini, M., Pozzetti, L., Piazza, F., Cantelli-Forti, G., Roda, A. Hepatology (1999) [Pubmed]
  25. Functional Modulation of Nuclear Steroid Receptors by Tauroursodeoxycholic Acid Reduces Amyloid {beta}-Peptide-Induced Apoptosis. Sol??, S., Amaral, J.D., Borralho, P.M., Ramalho, R.M., Castro, R.E., Aranha, M.M., Steer, C.J., Rodrigues, C.M. Mol. Endocrinol. (2006) [Pubmed]
  26. Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. Schoemaker, M.H., Gommans, W.M., Conde de la Rosa, L., Homan, M., Klok, P., Trautwein, C., van Goor, H., Poelstra, K., Haisma, H.J., Jansen, P.L., Moshage, H. J. Hepatol. (2003) [Pubmed]
  27. Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. Solá, S., Castro, R.E., Kren, B.T., Steer, C.J., Rodrigues, C.M. Biochemistry (2004) [Pubmed]
  28. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Dombrowski, F., Stieger, B., Beuers, U. Lab. Invest. (2006) [Pubmed]
  29. Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells. Ramalho, R.M., Ribeiro, P.S., Solá, S., Castro, R.E., Steer, C.J., Rodrigues, C.M. J. Neurochem. (2004) [Pubmed]
  30. Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. Rodrigues, C.M., Solá, S., Sharpe, J.C., Moura, J.J., Steer, C.J. Biochemistry (2003) [Pubmed]
  31. Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. Cai, W., Khaoustov, V.I., Xie, Q., Pan, T., Le, W., Yoffe, B. J. Hepatol. (2005) [Pubmed]
  32. Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. Ejiri, S., Eguchi, Y., Kishida, A., Ishigami, F., Kurumi, Y., Tani, T., Kodama, M. Transplantation (2001) [Pubmed]
  33. Effect of tauroursodeoxycholic acid on bile flow and calcium excretion in ischemia-reperfusion injury of rat livers. Ono, T., Nagasue, N., Kohno, H., Uchida, M., Takemoto, Y., Dhar, D.K., Nakamura, T. J. Hepatol. (1995) [Pubmed]
  34. Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. Heubi, J.E., Wiechmann, D.A., Creutzinger, V., Setchell, K.D., Squires, R., Couser, R., Rhodes, P. J. Pediatr. (2002) [Pubmed]
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