Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Glu-cys-oet (2S)-2-amino-4-[[(1S)-1- ethoxycarbonyl-2...

Synonyms: TEI-2306, AC1L3ONB, LS-172259, C10H18N2O5S, .gamma.-GCE, ...

Nishida, K. et al., Nishida, K. et al., Okamoto, T. et al.

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High impact information on gamma-Glutamylcysteinylethyl ester

GSH-depleted hepatocytes were incubated with gamma-glutamylcysteinylethyl ester (gamma-ECOEt), which is known to be converted to GSH via glutathione synthetase after its hydrolysis by esterase, at concentrations of 1.0 to 10 mM in order to replenish intracellular GSH [1].
A Se-deficient diet with or without daily subcutaneous injections of gamma-glutamylcysteinylethyl ester (gammay-GCE) (a membrane-permeating GSH precursor) was given to rats from gestation day 4 via the dam to postnatal day 14 [2].
We studied the mechanism by which gamma-glutamylcysteinylethyl ester (gamma-GCE), which is rapidly transported into hepatocytes and converted to reduced glutathione (GSH), prevents immunological hepatic injury [3].
Preventive effect of gamma-glutamylcysteinylethyl ester on immunological cell injury in isolated rat hepatocytes with anti-rat liver plasma membrane antiserum treatment [3].

References

Modulating role of endogenous reduced glutathione in tert-butyl hydroperoxide-induced cell injury in isolated rat hepatocytes. Nishida, K., Ohta, Y., Ishiguro, I. Free Radic. Biol. Med. (1997) [Pubmed]
Protective effect of gamma-glutamylcysteinylethyl ester on dysfunction of the selenium-deficient rat heart. Okamoto, T., Mizuta, K., Takahashi, T., Kishi, T., Kitahara, S., Komori, S., Hashimoto, K., Goshima, K. Biochem. Pharmacol. (1999) [Pubmed]
Preventive effect of gamma-glutamylcysteinylethyl ester on immunological cell injury in isolated rat hepatocytes with anti-rat liver plasma membrane antiserum treatment. Nishida, K., Ohta, Y., Ito, M., Ishiguro, I. Res. Commun. Chem. Pathol. Pharmacol. (1993) [Pubmed]

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