The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gss  -  glutathione synthetase

Rattus norvegicus

Synonyms: GSH synthetase, GSH-S, Glutathione synthase, Glutathione synthetase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gss


High impact information on Gss


Chemical compound and disease context of Gss


Biological context of Gss


Anatomical context of Gss


Associations of Gss with chemical compounds


Other interactions of Gss


Analytical, diagnostic and therapeutic context of Gss

  • Knowledge of this amino acid sequence is expected to facilitate elucidation of the sequence of the corresponding human enzyme and to lead to studies on the biochemical mechanisms involved in human GSH synthetase deficiency as well as to development of improved methods for prenatal diagnosis of these inborn diseases [6].
  • Setaria cervi: kinetic studies of filarial glutathione synthetase by high performance liquid chromatography [23].


  1. Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids. Purucker, E., Marschall, H.U., Geier, A., Gartung, C., Matern, S. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  2. Glutathione synthesis in normal liver and in Yoshida AH-130 hepatoma. Biocca, M.E., Canuto, R.A., Muzio, G., Rossi, M.A., Dianzani, M.U. Toxicologic pathology. (1986) [Pubmed]
  3. Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system. Kowluru, R.A., Kern, T.S., Engerman, R.L. Free Radic. Biol. Med. (1997) [Pubmed]
  4. Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase. Zhou, X.J., Vaziri, N.D., Wang, X.Q., Silva, F.G., Laszik, Z. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  5. Functional interactions between oxidative stress, membrane Na(+) permeability, and cell volume in rat hepatoma cells. Schlenker, T., Feranchak, A.P., Schwake, L., Stremmel, W., Roman, R.M., Fitz, J.G. Gastroenterology (2000) [Pubmed]
  6. Amino acid sequence of rat kidney glutathione synthetase. Huang, C.S., He, W., Meister, A., Anderson, M.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats. Lu, S.C., Cai, J., Kuhlenkamp, J., Sun, W.M., Takikawa, H., Takenaka, O., Horie, T., Yi, J., Kaplowitz, N. Hepatology (1996) [Pubmed]
  8. Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone. Yang, H., Zeng, Y., Lee, T.D., Yang, Y., Ou, X., Chen, L., Haque, M., Rippe, R., Lu, S.C. J. Biol. Chem. (2002) [Pubmed]
  9. Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites. Oppenheimer, L., Wellner, V.P., Griffith, O.W., Meister, A. J. Biol. Chem. (1979) [Pubmed]
  10. Modulating role of endogenous reduced glutathione in tert-butyl hydroperoxide-induced cell injury in isolated rat hepatocytes. Nishida, K., Ohta, Y., Ishiguro, I. Free Radic. Biol. Med. (1997) [Pubmed]
  11. Glutathione supplementation and training increases myocardial resistance to ischemia-reperfusion in vivo. Ramires, P.R., Ji, L.L. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  12. Novel kinetics of mammalian glutathione synthetase: characterization of gamma-glutamyl substrate cooperative binding. Luo, J.L., Huang, C.S., Babaoglu, K., Anderson, M.E. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. Gene expression in rats with Barrett's esophagus and esophageal adenocarcinoma induced by gastroduodenoesophageal reflux. Cheng, P., Gong, J., Wang, T., Chen, J., Liu, G.S., Zhang, R. World J. Gastroenterol. (2005) [Pubmed]
  14. Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase. Morales, A., García-Ruiz, C., Miranda, M., Marí, M., Colell, A., Ardite, E., Fernández-Checa, J.C. J. Biol. Chem. (1997) [Pubmed]
  15. Gating characteristics of a steeply voltage-dependent gap junction channel in rat Schwann cells. Chanson, M., Chandross, K.J., Rook, M.B., Kessler, J.A., Spray, D.C. J. Gen. Physiol. (1993) [Pubmed]
  16. Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. Ogihara, T., Asano, T., Katagiri, H., Sakoda, H., Anai, M., Shojima, N., Ono, H., Fujishiro, M., Kushiyama, A., Fukushima, Y., Kikuchi, M., Noguchi, N., Aburatani, H., Gotoh, Y., Komuro, I., Fujita, T. Diabetologia (2004) [Pubmed]
  17. Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: correlation with mitochondrial dysfunction and subsequent cell death. Ju, C., Yoon, K.N., Oh, Y.K., Kim, H.C., Shin, C.Y., Ryu, J.R., Ko, K.H., Kim, W.K. J. Neurochem. (2000) [Pubmed]
  18. Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia. Shepherd, A.G., Manson, M.M., Ball, H.W., McLellan, L.I. Carcinogenesis (2000) [Pubmed]
  19. Role of antioxidants in the O-hydroxyethyl-D-(Ser)8-cyclosporine A (SDZ IMM125)-induced apoptosis in rat hepatocytes. Grub, S., Trommer, W.E., Wolf, A. Biochem. Pharmacol. (2002) [Pubmed]
  20. Glycine prevention of cold ischemic injury in isolated hepatocytes. Marsh, D.C., Hjelmhaug, J.A., Vreugdenhil, P.K., Belzer, F.O., Southard, J.H. Cryobiology (1991) [Pubmed]
  21. Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat. Yan, C.C., Huxtable, R.J. Biochem. Pharmacol. (1996) [Pubmed]
  22. Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins. Wakusawa, S., Nakamura, S., Miyamoto, K. Jpn. J. Cancer Res. (1997) [Pubmed]
  23. Setaria cervi: kinetic studies of filarial glutathione synthetase by high performance liquid chromatography. Gupta, S., Srivastava, A.K., Banu, N. Exp. Parasitol. (2005) [Pubmed]
WikiGenes - Universities