Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Logran sodium 2-(imidazol-1-ylmethyl)-4,5...

Synonyms:

Takeuchi, H. et al., Ito, T. et al., Ogawa, T. et al., Ushiyama, S. et al., Asano, H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Imitrodast

Effects of thromboxane synthetase inhibitor (RS-5186) on experimentally-induced cerebral vasospasm [1].
In a thrombotic model induced by sodium arachidonate injection in rabbits, RS-5186 at 1 mg/kg p.o. completely protected against sudden death (ED50 = 0.12 mg/kg, 1 hr after dosing) and this protective effect extended over 8 hr [2].
In the RS-5186-treated group, the angiographic diameter of the basilar artery on Day 7 after subarachnoid hemorrhage was constricted to 60.9% +/- 11.6% (n = 9, mean +/- SD) of that on Day 0, before subarachnoid hemorrhage [1].

High impact information on Imitrodast

The thromboxane A2 synthetase inhibitors OKY-046 (10(-5) mol/l) and RS-5186 (10(-5) mol/l) did not attenuate the contractions either with or without endothelium [3].
This study was designed to determine the effect of sodium 6-(2-[1-(1H)-imidazolyl]methyl-4,5-dihydrobenzo[b] thiophene)carboxylate (RS-5186), a new thromboxane A2 (TXA2) synthetase inhibitor, on mitochondrial function and lysosomal integrity in ischemic myocardium [4].

Analytical, diagnostic and therapeutic context of Imitrodast

The remaining six dogs without administration of RS-5186 were used as a control group [1].
In contrast, in the RS-5186 treated group (2 mg/kg i.v.), both infarct size and MPO activity did not increase with prolongation of the reperfusion period (infarct size: 12.8 +/- 5.5 to 10.3 +/- 3.6%; MPO activity: 318.8 +/- 36.7 to 381.2 +/- 72.6 units/g wet weight) [5].

References

Effects of thromboxane synthetase inhibitor (RS-5186) on experimentally-induced cerebral vasospasm. Takeuchi, H., Tanabe, M., Okamoto, H., Yamazaki, M. Neurol. Res. (1999) [Pubmed]
RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. Ushiyama, S., Ito, T., Asai, F., Oshima, T., Terada, A., Matsuda, K., Yamazaki, M. Thromb. Res. (1988) [Pubmed]
Prostaglandin H2 as an endothelium-derived contracting factor modulates endothelin-1-induced contraction. Asano, H., Shimizu, K., Muramatsu, M., Iwama, Y., Toki, Y., Miyazaki, Y., Okumura, K., Hashimoto, H., Ito, T. J. Hypertens. (1994) [Pubmed]
Effect of a novel thromboxane A2 synthetase inhibitor on ischemia-induced mitochondrial dysfunction in canine hearts. Ogawa, T., Hieda, N., Sugiyama, S., Toki, Y., Ito, T., Ogawa, K., Satake, T., Ozawa, T. Arzneimittel-Forschung. (1988) [Pubmed]
Reduction of infarct size and infiltration of polymorphonuclear leukocytes by a thromboxane synthetase inhibitor. Studies in a rabbit ischemic heart model. Ito, T., Asai, F., Ushiyama, S., Matsuda, K., Oshima, T. Arzneimittel-Forschung. (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.