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Chemical Compound Review:

AG-G-48183 3-[2-[2-(3- hydroxyphenyl)ethyl-propyl...

Synonyms: AG-G-96343, SureCN11653919, CTK5C3275, LS-105094, PDSP1_000629, ...

Fortin, M. et al., Michael-Titus, A. et al., Sonsalla, P.K. et al., Suaudeau, C. et al., Dean, B. et al.

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Disease relevance of RU 24926

The reversion of RU 24926-induced analgesia by naloxone was not accompanied by a reversion of hypothermia [1].

High impact information on RU 24926

The di-(phenethyl)-amine derivatives, RU 24213 and RU 24926 are widely used as selective dopamine D2-receptor agonists [2].
This is confirmed for RU 24926, the more active of the two, using the field-stimulated rabbit vas-deferens [2].
In the hot plate test, the dopamine D2 receptor agonist RU 24926 as well as the mixed dopamine D1/D2 receptor agonist apomorphine dose dependently increased the nociceptive threshold of mice, as expressed by the jump latency [3].
Subacute treatment of rats with the D1 agonist, SK&F 38393, produced a significant decrease in SP content in the substantia nigra whereas treatment with the D2 agonist, RU 24926, elevated nigral SP concentrations [4].
Inhibition of [3H]dopamine uptake by platelets by the dopamine-D2 receptor agonist RU 24926 [5].

References

Analgesic effect of the direct D2 dopamine receptor agonist RU 24926 and cross tolerance with morphine. Suaudeau, C., Costentin, J. Fundamental & clinical pharmacology. (1995) [Pubmed]
The dopamine D2 agonists RU 24213 and RU 24926 are also kappa-opioid receptor antagonists. Fortin, M., Degryse, M., Petit, F., Hunt, P.F. Neuropharmacology (1991) [Pubmed]
Stimulation of dopamine D2 receptors induces an analgesia involving an opioidergic but non enkephalinergic link. Michael-Titus, A., Bousselmame, R., Costentin, J. Eur. J. Pharmacol. (1990) [Pubmed]
Opposite responses in the striato-nigral substance P system to D1 and D2 receptor activation. Sonsalla, P.K., Gibb, J.W., Hanson, G.R. Eur. J. Pharmacol. (1984) [Pubmed]
Inhibition of [3H]dopamine uptake by platelets by the dopamine-D2 receptor agonist RU 24926. Dean, B., Srikanthan, P., Copolov, D.L. J. Pharm. Pharmacol. (1991) [Pubmed]

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