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Chemical Compound Review

CHEMBL535150     3-[2-(phenethyl-propyl- amino)ethyl]phenol...

Synonyms: SureCN11650875, RU-24213, CTK8D4848, AR-1F1381, LS-105097, ...
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Disease relevance of 3-[2-(phenethyl-propyl-amino)ethyl]phenol

  • Long-lasting D2 receptor stimulation (8 days; 10 nM RU 24213) prevented this selective effect through activation of a pertussis toxin-sensitive G protein [1].
 

Psychiatry related information on 3-[2-(phenethyl-propyl-amino)ethyl]phenol

  • When, for comparison, the D2 agonist, RU 24213 (0.1-20 mg/kg IP), was tested for PE, SY, motor activity and SB, it displayed a behavioural pattern very similar to that obtained with SND 919 [2].
 

High impact information on 3-[2-(phenethyl-propyl-amino)ethyl]phenol

  • Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release [3].
  • In contrast, incubation with the D2 agonists [LY 171555, (+)-3-(3-hydroxyphenyl)-N-n-propylpiperidine, RU 24213] increased the soluble and decreased the particulate PKC activity [4].
  • Topographical effects of 0.3 to 10.0 mg/kg RU 24213, primarily induction of sniffing and ponderous locomotion with accompanying reductions in rearing, grooming, sifting and chewing, were not altered to any material extent in DARPP-32-null mice [5].
  • In contrast, quinpirole (1 mg/kg) and RU 24213 (3 mg/kg) produced more intense stereotypy consisting of rearing, sniffing and repetitive head movement in the two psychostimulant-treated groups than in the saline-treated group [6].
  • In both the NAc and CPu, the inhibition of neurons produced by iontophoresis of the D2 receptor agonists quinpirole or RU-24213 was attenuated by acute DA depletion via the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine (AMPT) [7].
 

Biological context of 3-[2-(phenethyl-propyl-amino)ethyl]phenol

References

  1. Chronic stimulation of D2 dopamine receptors specifically inhibits calcium but not potassium currents in rat lactotrophs. Lledo, P.M., Israel, J.M., Vincent, J.D. Brain Res. (1991) [Pubmed]
  2. Behavioural evidence that different neurochemical mechanisms underly stretching-yawning and penile erection induced in male rats by SND 919, a new selective D2 dopamine receptor agonist. Ferrari, F., Pelloni, F., Giuliani, D. Psychopharmacology (Berl.) (1993) [Pubmed]
  3. Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release. Raymond, V., Beaulieu, M., Labrie, F., Boissier, J. Science (1978) [Pubmed]
  4. Activation of D1 and D2 dopamine receptors inhibits protein kinase C activity in striatal synaptoneurosomes. Giambalvo, C.T., Wagner, R.L. J. Neurochem. (1994) [Pubmed]
  5. Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa "knockout" mutants congenic on the C57BL/6 genetic background. Nally, R.E., Kinsella, A., Tighe, O., Croke, D.T., Fienberg, A.A., Greengard, P., Waddington, J.L. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  6. D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine. Ujike, H., Akiyama, K., Otsuki, S. Psychopharmacology (Berl.) (1990) [Pubmed]
  7. D1 dopamine receptor stimulation enables the postsynaptic, but not autoreceptor, effects of D2 dopamine agonists in nigrostriatal and mesoaccumbens dopamine systems. Wachtel, S.R., Hu, X.T., Galloway, M.P., White, F.J. Synapse (1989) [Pubmed]
  8. Dopamine D2 receptor stimulation inhibits inositol phosphate generating system in rat striatal slices. Pizzi, M., Da Prada, M., Valerio, A., Memo, M., Spano, P.F., Haefely, W.E. Brain Res. (1988) [Pubmed]
  9. Profile of the selective dopamine D-2 receptor agonist N-0437: its effects on palatability- and deprivation-induced feeding, and operant responding for food. Rusk, I.N., Cooper, S.J. Physiol. Behav. (1988) [Pubmed]
 
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