The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Drd2  -  dopamine receptor D2

Rattus norvegicus

Synonyms: D(2) dopamine receptor, Dopamine D2 receptor
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Drd2


Psychiatry related information on Drd2


High impact information on Drd2


Chemical compound and disease context of Drd2


Biological context of Drd2


Anatomical context of Drd2


Associations of Drd2 with chemical compounds


Physical interactions of Drd2


Regulatory relationships of Drd2


Other interactions of Drd2


Analytical, diagnostic and therapeutic context of Drd2


  1. Low-Dose Dopamine Agonist Administration Blocks Vascular Endothelial Growth Factor (VEGF)-Mediated Vascular Hyperpermeability without Altering VEGF Receptor 2-Dependent Luteal Angiogenesis in a Rat Ovarian Hyperstimulation Model. Gomez, R., Gonzalez-Izquierdo, M., Zimmermann, R.C., Novella-Maestre, E., Alonso-Muriel, I., Sanchez-Criado, J., Remohi, J., Simon, C., Pellicer, A. Endocrinology (2006) [Pubmed]
  2. Localization of dopamine D2 receptors on cholinergic interneurons of the dorsal striatum and nucleus accumbens of the rat. Alcantara, A.A., Chen, V., Herring, B.E., Mendenhall, J.M., Berlanga, M.L. Brain Res. (2003) [Pubmed]
  3. The effect of octreotide and bromocriptine on expression of a pro-apoptotic Bax protein in rat prolactinoma. Gruszka, A., Kunert-Radek, J., Pawlikowski, M. Folia Histochem. Cytobiol. (2004) [Pubmed]
  4. Central dopaminergic origin of bromocriptine induced tachycardia in normotensive rats. Lahlou, S., Duarte, G.P., Demenge, P. Cardiovasc. Res. (1993) [Pubmed]
  5. The neurokinin1 receptor antagonist CP-99,994 reduces catalepsy produced by the dopamine D2 receptor antagonist raclopride: correlation with extracellular acetylcholine levels in striatum. Anderson, J.J., Randall, S., Chase, T.N. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  6. Biphasic effects of dopamine D-2 receptor agonists on sleep and wakefulness in the rat. Monti, J.M., Hawkins, M., Jantos, H., D'Angelo, L., Fernández, M. Psychopharmacology (Berl.) (1988) [Pubmed]
  7. Involvement of the nucleus accumbens-ventral pallidal pathway in postictal behavior induced by a hippocampal afterdischarge in rats. Ma, J., Brudzynski, S.M., Leung, L.W. Brain Res. (1996) [Pubmed]
  8. Dopamine D2 receptor gene expression in rat lines selected for differences in voluntary alcohol consumption. Syvälahti, E.K., Pohjalainen, T., Korpi, E.R., Pälvimäki, E.P., Ovaska, T., Kuoppamäki, M., Hietala, J. Alcohol. Clin. Exp. Res. (1994) [Pubmed]
  9. Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. Hefco, V., Yamada, K., Hefco, A., Hritcu, L., Tiron, A., Olariu, A., Nabeshima, T. Eur. J. Pharmacol. (2003) [Pubmed]
  10. REM sleep deprivation alters dopamine D2 receptor binding in the rat frontal cortex. Brock, J.W., Hamdi, A., Ross, K., Payne, S., Prasad, C. Pharmacol. Biochem. Behav. (1995) [Pubmed]
  11. Structure and functional expression of cloned rat serotonin 5HT-2 receptor. Pritchett, D.B., Bach, A.W., Wozny, M., Taleb, O., Dal Toso, R., Shih, J.C., Seeburg, P.H. EMBO J. (1988) [Pubmed]
  12. Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal gamma-aminobutyric acid transmission in the conscious rat. Sommer, W., Rimondini, R., O'Connor, W., Hansson, A.C., Ungerstedt, U., Fuxe, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Konradi, C., Kobierski, L.A., Nguyen, T.V., Heckers, S., Hyman, S.E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  14. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Nguyen, T.V., Kosofsky, B.E., Birnbaum, R., Cohen, B.M., Hyman, S.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  15. Molecular dynamics of dopamine at the D2 receptor. Dahl, S.G., Edvardsen, O., Sylte, I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  16. N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Belluzzi, J.D., Domino, E.F., May, J.M., Bankiewicz, K.S., McAfee, D.A. Mov. Disord. (1994) [Pubmed]
  17. Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin. McQueen, D.S., Mir, A.K. Br. J. Pharmacol. (1984) [Pubmed]
  18. Effect of repeated L-DOPA, bromocriptine, or lisuride administration on preproenkephalin-A and preproenkephalin-B mRNA levels in the striatum of the 6-hydroxydopamine-lesioned rat. Henry, B., Crossman, A.R., Brotchie, J.M. Exp. Neurol. (1999) [Pubmed]
  19. Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems. Fedorova, I., Hashimoto, A., Fecik, R.A., Hedrick, M.P., Hanus, L.O., Boger, D.L., Rice, K.C., Basile, A.S. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  20. Tolerance to peripheral, but not central, effects of ropinirole, a selective dopamine D2-like receptor agonist. Parker, S.G., Raval, P., Yeulet, S., Eden, R.J. Eur. J. Pharmacol. (1994) [Pubmed]
  21. Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. Wang, C., Buck, D.C., Yang, R., Macey, T.A., Neve, K.A. J. Neurochem. (2005) [Pubmed]
  22. Monoamine oxidase inhibitor sensitive site implicated in sensitization to quinpirole. Culver, K.E., Szechtman, H. Eur. J. Pharmacol. (1997) [Pubmed]
  23. Dopamine D2 receptor mRNA in the pituitary during the oestrous cycle, pregnancy and lactation in the rat. Zabavnik, J., Wu, W.X., Eidne, K.A., McNeilly, A.S. Mol. Cell. Endocrinol. (1993) [Pubmed]
  24. Selective changes in gene expression in cortical regions sensitive to amphetamine during the neurodegenerative process. Bowyer, J.F., Harris, A.J., Delongchamp, R.R., Jakab, R.L., Miller, D.B., Little, A.R., O'Callaghan, J.P. Neurotoxicology (2004) [Pubmed]
  25. Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats. Carroll, J.L., Boyle, K.M., Wasicko, M.J., Sterni, L.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  26. Molecular, chemical, and anatomical characterization of globus pallidus dopamine D2 receptor mRNA-containing neurons. Hoover, B.R., Marshall, J.F. Synapse (2004) [Pubmed]
  27. Prolactin modulation of nitric oxide and TNF-alpha production by peripheral neutrophils in rats. Meli, R., Raso, G.M., Gualillo, O., Pacilio, M., Di Carlo, R. Life Sci. (1997) [Pubmed]
  28. The dopamine D2 receptor is expressed in GH3 cells. Johnston, J.M., Wood, D.F., Bolaji, E.A., Johnston, D.G. J. Mol. Endocrinol. (1991) [Pubmed]
  29. Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-beta1, and TGF-beta type II receptor interact to inhibit the growth of pituitary lactotropes. Sarkar, D.K., Chaturvedi, K., Oomizu, S., Boyadjieva, N.I., Chen, C.P. Endocrinology (2005) [Pubmed]
  30. Repeated sucrose access influences dopamine D2 receptor density in the striatum. Bello, N.T., Lucas, L.R., Hajnal, A. Neuroreport (2002) [Pubmed]
  31. Effects of immobilization stress on estrogen-induced surges of luteinizing hormone and prolactin in ovariectomized rats. Kam, K., Park, Y., Cheon, M., Son, G.H., Kim, K., Ryu, K. Endocrine (2000) [Pubmed]
  32. Dopamine-induced protection against indomethacin-evoked intestinal lesions in rats--role of anti-intestinal motility mediated by D2 receptors. Miyazawa, T., Matsumoto, M., Kato, S., Takeuchi, K. Med. Sci. Monit. (2003) [Pubmed]
  33. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Seeman, P., Corbett, R., Van Tol, H.H. Neuropsychopharmacology (1997) [Pubmed]
  34. Subsets of neurotensin-immunoreactive neurons in the rat striatal complex following antagonism of the dopamine D2 receptor: an immunohistochemical double-labeling study using antibodies against Fos. Senger, B., Brog, J.S., Zahm, D.S. Neuroscience (1993) [Pubmed]
  35. Effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on the prolactin suppression induced by a series of full and partial dopamine D2 receptor agonists in male rats. Ekman, A., Eriksson, E. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  36. Inhibitory role of endophilin 3 in receptor-mediated endocytosis. Sugiura, H., Iwata, K., Matsuoka, M., Hayashi, H., Takemiya, T., Yasuda, S., Ichikawa, M., Yamauchi, T., Mehlen, P., Haga, T., Yamagata, K. J. Biol. Chem. (2004) [Pubmed]
  37. Central administration of the neurotensin receptor antagonist SR48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. McCormick, S.E., Stoessl, A.J. Neuroscience (2003) [Pubmed]
  38. Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Svenningsson, P., Le Moine, C., Kull, B., Sunahara, R., Bloch, B., Fredholm, B.B. Neuroscience (1997) [Pubmed]
  39. Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures. Green, A.R., O'Shea, E., Saadat, K.S., Elliott, J.M., Colado, M.I. Br. J. Pharmacol. (2005) [Pubmed]
  40. Effects of estrogen and epidermal growth factor on prolactin and Pit-1 mRNA in GH3 cells. Zhang, K., Kulig, E., Jin, L., Lloyd, R.V. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
  41. Dopamine inhibits prolactin secretion stimulated by the calcium channel agonist Bay-K-8644 through a pertussis toxin-sensitive G protein in anterior pituitary cells. Enjalbert, A., Musset, F., Chénard, C., Priam, M., Kordon, C., Heisler, S. Endocrinology (1988) [Pubmed]
  42. Simultaneous measurement of [Ca2+]i and secretion-coupled membrane turnover, by single cell fluorescence microscopy. Shorte, S.L., Stafford, S.J., Collett, V.J., Schofield, J.G. Cell Calcium (1995) [Pubmed]
  43. Modulation of [3H]dopamine release by neuropeptide Y in rat striatal slices. Tsuda, K., Tsuda, S., Nishio, I., Goldstein, M., Masuyama, Y. Eur. J. Pharmacol. (1997) [Pubmed]
  44. Localization of dopamine receptor subtypes in systemic arteries. Amenta, F., Barili, P., Bronzetti, E., Felici, L., Mignini, F., Ricci, A. Clin. Exp. Hypertens. (2000) [Pubmed]
  45. Brain dopamine D-2 receptor mechanisms in spontaneously hypertensive rats. Van den Buuse, M., Jones, C.R., Wagner, J. Brain Res. Bull. (1992) [Pubmed]
  46. Effects of binge pattern cocaine administration on dopamine D1 and D2 receptors in the rat brain: an in vivo study using positron emission tomography. Tsukada, H., Kreuter, J., Maggos, C.E., Unterwald, E.M., Kakiuchi, T., Nishiyama, S., Futatsubashi, M., Kreek, M.J. J. Neurosci. (1996) [Pubmed]
  47. Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats. Scherfler, C., Scholz, S.W., Donnemiller, E., Decristoforo, C., Oberladstätter, M., Stefanova, N., Diederen, E., Virgolini, I., Poewe, W., Wenning, G.K. Neuroimage (2005) [Pubmed]
  48. Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. De Vries, T.J., Schoffelmeer, A.N., Binnekade, R., Raasø, H., Vanderschuren, L.J. Neuropsychopharmacology (2002) [Pubmed]
WikiGenes - Universities