Disease relevance of T 1348

• Norastemizole block of HERG channels is weaker; thus, the risk of producing ventricular arrhythmias may be lower [1].

High impact information on T 1348

• Effects of the anti-allergics astemizole and norastemizole on Fc epsilon RI receptor-mediated signal transduction processes [2].
• Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole [3].
• The surface coil localized fluorine MR spectrum was monitored in the heart and liver at baseline and after oral administration of multiple doses of tecastemizole [3].
• On the other hand, in the studies of histamine release from rat peritoneal mast cells induced by compound 48/80 or from lung fragments in actively sensitized guinea pigs, desmethylastemizole, 6-hydroxydesmethylastemizole and norastemizole were much less potent than was astemizole [4].

Associations of T 1348 with other chemical compounds

• Our objective in the present work was to study the effects of desmethylastemizole, norastemizole, and astemizole on HERG K+ channels [1].

Gene context of T 1348

• Norastemizole also blocked HERG current; however, block was incomplete and required higher drug concentrations (half-maximal block of 27.7 nM) [1].

References