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Chemical Compound Review

Soltara     1-[(4-fluorophenyl)methyl]-N- (4...

Synonyms: Norastemizole, Tecastemizole, CHEMBL61301, SureCN18200, CHEBI:190981, ...
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Disease relevance of T 1348


High impact information on T 1348


Associations of T 1348 with other chemical compounds


Gene context of T 1348

  • Norastemizole also blocked HERG current; however, block was incomplete and required higher drug concentrations (half-maximal block of 27.7 nM) [1].


  1. Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. Zhou, Z., Vorperian, V.R., Gong, Q., Zhang, S., January, C.T. J. Cardiovasc. Electrophysiol. (1999) [Pubmed]
  2. Effects of the anti-allergics astemizole and norastemizole on Fc epsilon RI receptor-mediated signal transduction processes. Fischer, M.J., Paulussen, J.J., Kok-Van Esterik, J.A., Van der Heijden, V.S., De Mol, N.J., Janssen, L.H. Eur. J. Pharmacol. (1997) [Pubmed]
  3. Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole. Schneider, E., Bolo, N.R., Frederick, B., Wilkinson, S., Hirashima, F., Nassar, L., Lyoo, I.K., Koch, P., Jones, S., Hwang, J., Sung, Y., Villafuerte, R.A., Maier, G., Hsu, R., Hashoian, R., Renshaw, P.F. Journal of clinical pharmacy and therapeutics. (2006) [Pubmed]
  4. Antiallergic effects of major metabolites of astemizole in rats and guinea pigs. Kamei, C., Mio, M., Izushi, K., Kitazumi, K., Tsujimoto, S., Fujisawa, K., Adachi, Y., Tasaka, K. Arzneimittel-Forschung. (1991) [Pubmed]
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