The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Soltara     1-[(4-fluorophenyl)methyl]-N- (4...

Synonyms: Norastemizole, Tecastemizole, CHEMBL61301, SureCN18200, CHEBI:190981, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of T 1348

 

High impact information on T 1348

 

Associations of T 1348 with other chemical compounds

 

Gene context of T 1348

  • Norastemizole also blocked HERG current; however, block was incomplete and required higher drug concentrations (half-maximal block of 27.7 nM) [1].

References

  1. Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. Zhou, Z., Vorperian, V.R., Gong, Q., Zhang, S., January, C.T. J. Cardiovasc. Electrophysiol. (1999) [Pubmed]
  2. Effects of the anti-allergics astemizole and norastemizole on Fc epsilon RI receptor-mediated signal transduction processes. Fischer, M.J., Paulussen, J.J., Kok-Van Esterik, J.A., Van der Heijden, V.S., De Mol, N.J., Janssen, L.H. Eur. J. Pharmacol. (1997) [Pubmed]
  3. Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole. Schneider, E., Bolo, N.R., Frederick, B., Wilkinson, S., Hirashima, F., Nassar, L., Lyoo, I.K., Koch, P., Jones, S., Hwang, J., Sung, Y., Villafuerte, R.A., Maier, G., Hsu, R., Hashoian, R., Renshaw, P.F. Journal of clinical pharmacy and therapeutics. (2006) [Pubmed]
  4. Antiallergic effects of major metabolites of astemizole in rats and guinea pigs. Kamei, C., Mio, M., Izushi, K., Kitazumi, K., Tsujimoto, S., Fujisawa, K., Adachi, Y., Tasaka, K. Arzneimittel-Forschung. (1991) [Pubmed]
 
WikiGenes - Universities