Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL353882 (3S,8S,9S,10R,13R,14S,17R)- 17-[(2R,6R)-7...

Synonyms: SureCN288494, CHEBI:76591, HMDB02103, AC1L3XNP, LMST01010088, ...

Leoni, V. et al., Larsson, D.A. et al.

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Disease relevance of LMST01010088

In the present study, we investigated the cytotoxic effects of 7beta-hydroxycholesterol (7betaOH), 7-ketocholesterol (7keto), 25-hydroxycholesterol (25OH), and 27-hydroxycholesterol (27OH) on U937 monocytic cells, both individually and in atheroma-relevant mixtures mimicking the oxysterol composition reported in human atheroma lesions [1].
Patients with active demyelinating diseases had increased levels of 24OHC in CSF with a relatively high 24OHC/27OHC ratio [2].
Patients with meningitis in general had high levels of both steroids with a low 24OHC/27OHC ratio [2].
Patients with multiple sclerosis had a tendency to have higher levels of 24OHC during active periods with a high 24OHC/ 27OHC ratio [2].

Psychiatry related information on LMST01010088

Patients with Alzheimer's disease had slightly increased levels of 24OHC in CSF with less increase in 27OHC [2].

High impact information on LMST01010088

Although single 25OH or 27OH exhibited quenching effects on both 7betaOH- and 7keto-induced cell death, the combination of all four oxysterols in atheroma-relevant proportions was proapoptotic [1].
HYPOTHESIS TO BE TESTED: Neuronal damage and/or demyelination causes increased flux of 24OHC from the brain into the cerebrospinal fluid (CSF), whereas a defect blood-brain barrier causes increased flux of 27OHC from the circulation into the CSF [2].

References

Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. Larsson, D.A., Baird, S., Nyhalah, J.D., Yuan, X.M., Li, W. Free Radic. Biol. Med. (2006) [Pubmed]
Diagnostic use of cerebral and extracerebral oxysterols. Leoni, V., Masterman, T., Mousavi, F.S., Wretlind, B., Wahlund, L.O., Diczfalusy, U., Hillert, J., Björkhem, I. Clin. Chem. Lab. Med. (2004) [Pubmed]

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