Chemical Compound Review:
CHEMBL169046 (3S,8S,9S,10R,13R,14S,17R)- 17-[(2R)-6...
Synonyms:
SureCN177267, CPD-7285, AG-E-56772, CHEBI:42977, CTK4E6668, ...
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- Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. Nohturfft, A., Brown, M.S., Goldstein, J.L. Proc. Natl. Acad. Sci. U.S.A. (1998)
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- cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Lund, E.G., Guileyardo, J.M., Russell, D.W. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Differential effects of transforming growth factor type beta on the growth and function of adrenocortical cells in vitro. Hotta, M., Baird, A. Proc. Natl. Acad. Sci. U.S.A. (1986)
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- Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol, and serum. Chen, H.W., Cavenee, W.K., Kandutsch, A.A. J. Biol. Chem. (1979)
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- Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells. Cao, G., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (1996)
- Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. Adams, C.M., Reitz, J., De Brabander, J.K., Feramisco, J.D., Li, L., Brown, M.S., Goldstein, J.L. J. Biol. Chem. (2004)
- Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. Agellon, L.B., Drover, V.A., Cheema, S.K., Gbaguidi, G.F., Walsh, A. J. Biol. Chem. (2002)
- Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. Moreira, E.F., Jaworski, C., Li, A., Rodriguez, I.R. J. Biol. Chem. (2001)
- Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells. Faust, J.R., Luskey, K.L., Chin, D.J., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Difference in the ability of compactin and oxidized cholesterol, both known inhibitors of cholesterol biosynthesis, to suppress in vitro immune responses. Humphries, G.M. Cancer Res. (1981)
- Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate. Chang, T.Y., Limanek, J.S., Chang, C.C. J. Biol. Chem. (1981)
- Purification of oxysterol binding protein from hamster liver cytosol. Dawson, P.A., Van der Westhuyzen, D.R., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (1989)
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