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Chemical Compound Review:

Ppapapa [[[(2R,3R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: KST-1A7474, AR-1A8127, AC1L2O8E, Pppa2'p5'A2'p5'A, Pppa2'-5'A2'-5'A, ...

Karikó, K. et al., Vaquero, C.M. et al., Liu, X.Y., den Hartog, J.A. et al., Liu, X.Y. et al.

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High impact information on Ppapapa

n-Decyl-NHpppA2'p5'A2'p5'A, a gamma-substituted, phosphatase-resistant pppA2'p5'A2'p5'A analog, gives similar rRNA degradation pattern in interferon-treated HeLa cell extracts--even at a concentration of 10(-9)M--as the natural compound does [1].
Inhibition of protein synthesis and activation of nuclease in rabbit reticulocyte lysates by the unusual oligonucleotide pppA2'p5'A2'p5'A [2].
Enhancement of phagocytosis of macrophages and the activity of natural killer cells by pppA2'p5'A2'p5'A (2'-5'P3A3) has been described [3].
Mechanism of interferon action. Activation of macrophages and antagonism to alpha-feto-protein by pppA2'p5'A2'p5'A [4].
Chemical synthesis of an effective inhibitor of protein synthesis in eukaryotic cells: pppA2'-5'A2'-5'A and some analogues [5].

References

n-Decyl-NHpppA2'p5'A2'p5'A A phosphatase-resistant, active pppA2'p5'A2'p5'A analog. Karikó, K., Ludwig, J. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
Inhibition of protein synthesis and activation of nuclease in rabbit reticulocyte lysates by the unusual oligonucleotide pppA2'p5'A2'p5'A. Vaquero, C.M., Clemens, M.J. Eur. J. Biochem. (1979) [Pubmed]
Progress in experimental pathology in the People's Republic of China. Action of pppA2'p5'A2'p5'A on the immune system. Liu, X.Y. J. Exp. Pathol. (1984) [Pubmed]
Mechanism of interferon action. Activation of macrophages and antagonism to alpha-feto-protein by pppA2'p5'A2'p5'A. Liu, X.Y., Zheng, H.D., Wang, N., Li, B.L., Ren, W.H., Kong, R.L., Wang, D.B. Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. (1983) [Pubmed]
Chemical synthesis of an effective inhibitor of protein synthesis in eukaryotic cells: pppA2'-5'A2'-5'A and some analogues. den Hartog, J.A., Wijnands, R.A., van Boom, J.H., Crea, R. Nucleic Acids Symp. Ser. (1980) [Pubmed]

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