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Chemical Compound Review

AC1L2T18     3-(3-dimethylaminopropyl)-4- hydroxy-N-(4...

Synonyms: GR 55562, 172854-55-6
This record was replaced with 128018.
 
 
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Psychiatry related information on GR55562

 

High impact information on GR55562

  • Differentiation between partial agonists and neutral 5-HT1B antagonists by chemical modulation of 3-[3-(N,N-dimethylamino)propyl]-4-hydroxy- N-[4-(pyridin-4-yl)phenyl]benzamide (GR-55562) [2].
  • The enhancing effect of 5-HT on cell migration was markedly inhibited in the presence of ketanserin, a 5-HT2 receptor antagonist, but not by GR 55562, a 5-HT1 receptor antagonist [3].
  • Male Wistar rats, implanted bilaterally with cannulae in the VTA, were microinjected with GR 55562 (an antagonist of 5-HT(1B) receptors) or CP 93129 (an agonist of 5-HT(1B) receptors) [4].
  • No change in cocaine sensitization was observed after intra-VTA microinjections of GR 55562 (0.3-3 microg/side) or CP 93129 (0.1-1 microg/side) [4].
  • Our findings indicate that cocaine induced hyperlocomotion is modified by 5-HT1B receptor ligands microinjected into the accumbens shell, but not core, this modification consisting in inhibitory and facilitatory effects of the 5-HT1B receptor antagonist (GR 55562) and agonist (CP 93129), respectively [5].
 

Gene context of GR55562

  • Male Wistar rats were implanted bilaterally with cannulae into the accumbens shell or core, and then were locally injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of 5-HT1B receptors) [5].

References

  1. Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats. Papla, I., Filip, M., Przegaliński, E. Polish journal of pharmacology. (2002) [Pubmed]
  2. Differentiation between partial agonists and neutral 5-HT1B antagonists by chemical modulation of 3-[3-(N,N-dimethylamino)propyl]-4-hydroxy- N-[4-(pyridin-4-yl)phenyl]benzamide (GR-55562). Lamothe, M., Pauwels, P.J., Belliard, K., Schambel, P., Halazy, S. J. Med. Chem. (1997) [Pubmed]
  3. 5-Hydroxytryptamine augments migration of human aortic smooth muscle cells through activation of RhoA and ERK. Matsusaka, S., Wakabayashi, I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. Przegaliński, E., Papla, I., Siwanowicz, J., Filip, M. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2004) [Pubmed]
  5. Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats. Przegaliński, E., Filip, M., Papla, I., Czepiel, K. J. Physiol. Pharmacol. (2002) [Pubmed]
 
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