Chemical Compound Review:
CHEMBL17815 7-chloro-2-[(4- methoxyphenyl)methyl]-3...
Synonyms:
AG-D-12121, SureCN6009815, ACMC-20m5l1, CHEBI:120283, CTK4A1301, ...
- L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor. Belanger, P., Maycock, A., Guindon, Y., Bach, T., Dollob, A.L., Dufresne, C., Ford-Hutchinson, A.W., Gale, P.H., Hopple, S., Lau, C.K. Can. J. Physiol. Pharmacol. (1987)
- MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. Rouzer, C.A., Ford-Hutchinson, A.W., Morton, H.E., Gillard, J.W. J. Biol. Chem. (1990)
- The in vivo production of peptide leukotrienes after pulmonary anaphylaxis in the rat. Foster, A., Letts, G., Charleson, S., Fitzsimmons, B., Blacklock, B., Rokach, J. J. Immunol. (1988)
- Inhibition of human leukocyte 5-lipoxygenase by a 4-hydroxybenzofuran, L-656,224. Evidence for enzyme reduction and inhibitor degradation. Rouzer, C.A., Riendeau, D., Falgueyret, J.P., Lau, C.K., Gresser, M.J. Biochem. Pharmacol. (1991)
- Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224. Lau, C.K., Bélanger, P.C., Scheigetz, J., Dufresne, C., Williams, H.W., Maycock, A.L., Guindon, Y., Bach, T., Dallob, A.L., Denis, D. J. Med. Chem. (1989)
- Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. Gyömber, E., Vattay, P., Szabo, S., Rainsford, K.D. J. Gastroenterol. Hepatol. (1996)