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Chemical Compound Review:

Tocris-0486 8-phenyl-1,3-dipropyl-7H- purine-2,6-dione

Synonyms: CHEMBL158507, SureCN661108, SureCN12648449, CHEBI:361373, AC1L2UFC, ...

Wesley, R.C. et al., Priebe, T. et al.

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Disease relevance of Tocris-0486

In halothane-nitrous oxide-anesthetized pigs, the effect of the competitive adenosine antagonist, BW-A1433U (a derivative of 1,3-dipropyl-8-phenylxanthine), on postdefibrillation bradyarrhythmia and hemodynamic depression was investigated [1].

High impact information on Tocris-0486

Agents that stimulate NK cell activity (deoxyadenosine, A1 receptor agonists, F-ara-AMP) do not increase further the 1.5-fold enhancement produced by a 10(-6) M concentration of 1,3-dipropyl-8-phenylxanthine amine congener [2].

References

Role of endogenous adenosine in postdefibrillation bradyarrhythmia and hemodynamic depression. Wesley, R.C., Belardinelli, L. Circulation (1989) [Pubmed]
Adenosine receptors and modulation of natural killer cell activity by purine nucleosides. Priebe, T., Platsoucas, C.D., Nelson, J.A. Cancer Res. (1990) [Pubmed]

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