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Chemical Compound Review

CHEMBL423239     4-(2,6-dioxo-1,3-dipropyl-7H- purin-8...

Synonyms: CHEBI:361391, AC1L3TX7, BW 1433U, BW A1433U, BW A-1433U, ...
 
 
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Disease relevance of BW A1433U

  • Thus, BW-A1433U can reverse and prevent postdefibrillation bradyarrhythmia and hemodynamic depression [1].
  • Responses to R-PIA were blocked by BW-A1433U (1 microM) or by pretreatment of cells with pertussis toxin [2].
  • Ventricular bigeminy, the most prominent arrhythmia seen in this study, was significantly reduced by adenosine deaminase and BW A1433U [3].
  • After instrumentation dogs were randomly assigned to one of four treatment groups: 14 dogs were pretreated before hypoxia with adenosine deaminase (n = 7, group I) or its vehicle (n = 7, group II) while 12 other dogs were pretreated with the A1 selective adenosine receptor antagonist BW A1433U (n = 6, group III) or its vehicle (n = 6, group IV) [3].
  • Hearts preconditioned with BW-A1433U had virtually no decrease in pHi during the 30-min sustained period of ischemia; after 30 min of ischemia, the pH in untreated hearts was 5.97 +/- 0.16 compared with 6.52 +/- 0.10 in preconditioned hearts and 6.90 +/- 0.08 in hearts preconditioned plus BW-A1433U [4].
 

High impact information on BW A1433U

 

Gene context of BW A1433U

References

  1. Role of endogenous adenosine in postdefibrillation bradyarrhythmia and hemodynamic depression. Wesley, R.C., Belardinelli, L. Circulation (1989) [Pubmed]
  2. Regulation of GH3-cell function via adenosine A1 receptors. Inhibition of prolactin release, cyclic AMP production and inositol phosphate generation. Delahunty, T.M., Cronin, M.J., Linden, J. Biochem. J. (1988) [Pubmed]
  3. Adenosine deaminase and BW A1433U attenuate hypoxia-induced ventricular ectopy. Leone, R.J., Friedrichs, G.S., Merrill, G.F. J. Appl. Physiol. (1993) [Pubmed]
  4. Effects of adenosine antagonists on hexose uptake and preconditioning in perfused rat heart. Murphy, E., Fralix, T.A., London, R.E., Steenbergen, C. Am. J. Physiol. (1993) [Pubmed]
  5. Adenosine modulation of tumor necrosis factor-alpha-induced neutrophil activation. Barnes, C.R., Mandell, G.L., Carper, H.T., Luong, S., Sullivan, G.W. Biochem. Pharmacol. (1995) [Pubmed]
  6. Antagonism of the effects of adenosine and hypoxia on atrioventricular conduction time by two novel alkylxanthines: correlation with binding to adenosine A1 receptors. Clemo, H.F., Bourassa, A., Linden, J., Belardinelli, L. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  7. Inhibition of glucose transport in human red blood cells by adenosine antagonists. Gabel, S.A., O'Connell, T.M., Murphy, E., London, R.E. Am. J. Physiol. (1997) [Pubmed]
 
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