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Chemical Compound Review:

Sestamibi 1-isocyano-2-methoxy-2- methyl-propane

Synonyms: MIBI, RP-30, AG-D-26335, ACMC-20mcai, RP 30, ...

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Disease relevance of 2-Methoxyisobutylisonitrile

Effects of hypoxia and ouabain on transcapillary exchange of [99mTc]hexakis (2-methoxyisobutylisonitrile) [SESTAMIBI, also known as MIBI or HEXAMIBI] and 201TI were investigated with indicator-dilution studies using isolated rabbit hearts [1].
Technetium-99m 2-methoxyisobutylisonitrile (99mTc-MIBI) has been proposed as a potential tracer in patients with multiple myeloma (MM) [2].
Technetium-99m labelled 2-methoxyisobutylisonitrile (MIBI) has been extensively utilised for preoperative localisation of parathyroid adenomas [3].

High impact information on 2-Methoxyisobutylisonitrile

Myocellular uptake and retention of technetium-99m-hexakis (2-methoxyisobutylisonitrile) (Tc-MIBI), a lipophilic cationic myocardial perfusion and viability imaging agent, is dependent on both mitochondrial and plasma-membrane potentials [4].
Technetium-99m 2-methoxyisobutylisonitrile (99mTc-MIBI or setamibi) has recently been proposed for use in the evaluation of multiple myeloma (MM) [5].
The aim of the present study was to evaluate the clinical significance of this technique in differentiated thyroid carcinoma and to compare the results with other imaging modalities, particularly with whole-body 131iodine scintigraphy (WBS) and hexakis (2-methoxyisobutylisonitrile) (99m)technetium (I) scintigraphy (MIBI) [6].
Hexakis (2-methoxyisobutylisonitrile) technetium-99m (99mTc-SestaMIBI) is a radiopharmaceutical used in nuclear medicine for myocardial perfusion imaging [7].
Hexakis (2-methoxyisobutylisonitrile) technetium-99m (99mTc-MIBI) is a gamma-emitting radiopharmaceutical probe currently in clinical use to evaluate myocardial perfusion [8].

Associations of 2-Methoxyisobutylisonitrile with other chemical compounds

Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts [9].

References

Comparison of hypoxia and ouabain effects on the myocardial uptake kinetics of technetium-99m hexakis 2-methoxyisobutyl isonitrile and thallium-201. Meerdink, D.J., Leppo, J.A. J. Nucl. Med. (1989) [Pubmed]
Different patterns of technetium-99m sestamibi uptake in multiple myeloma. Pace, L., Catalano, L., Pinto, A., De Renzo, A., Di Gennaro, F., Califano, C., Del Vecchio, S., Rotoli, B., Salvatore, M. European journal of nuclear medicine. (1998) [Pubmed]
The value of oblique pinhole images in pre-operative localisation with 99mTc-MIBI for primary hyperparathyroidism. Ho Shon, I.A., Bernard, E.J., Roach, P.J., Delbridge, L.W. European journal of nuclear medicine. (2001) [Pubmed]
Enhancement by tetraphenylborate of technetium-99m-MIBI uptake kinetics and accumulation in cultured chick myocardial cells. Piwnica-Worms, D., Kronauge, J.F., Chiu, M.L. J. Nucl. Med. (1991) [Pubmed]
Predictive value of technetium-99m sestamibi in patients with multiple myeloma and potential role in the follow-up. Pace, L., Catalano, L., Del Vecchio, S., Di Gennaro, F., De Renzo, A., Sica, G., Califano, C., Tedesco, N., Borrelli, G., Rotoli, B., Salvatore, M. European journal of nuclear medicine. (2001) [Pubmed]
Comparison of 18FDG-PET with 131iodine and 99mTc-sestamibi scintigraphy in differentiated thyroid cancer. Grünwald, F., Menzel, C., Bender, H., Palmedo, H., Willkomm, P., Ruhlmann, J., Franckson, T., Biersack, H.J. Thyroid (1997) [Pubmed]
Applications of 99mTc-sestamibi in oncology. Maffioli, L., Steens, J., Pauwels, E., Bombardieri, E. Tumori. (1996) [Pubmed]
Microprobe analysis of Tc-MIBI in heart cells: calculation of mitochondrial membrane potential. Backus, M., Piwnica-Worms, D., Hockett, D., Kronauge, J., Lieberman, M., Ingram, P., LeFurgey, A. Am. J. Physiol. (1993) [Pubmed]
Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts. Chiu, M.L., Kronauge, J.F., Piwnica-Worms, D. J. Nucl. Med. (1990) [Pubmed]

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