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Chemical Compound Review

Sp-8-Cl-Camps     cyclohexane-1,2-diamine; platinum(+2)...

Synonyms: AC1L33S3, 8-Chloro-camps, 142754-28-7, 142928-30-1, Quinato(chda)Pt, ...
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Psychiatry related information on Sp-8-Cl-Camps

  • Enhancement of PKA activity late in the critical period with Sp-8-Cl-cAMPS did not increase plasticity [1].
  • In the context-signal learning paradigm of the crab Chasmagnathus, the protein kinase (PKA) activator Sp-5,6-DCl-cBIMPS facilitated long-term memory (LTM) induced by spaced training while the PKA inhibitor 8-chloroadenosine-3', 5'-monophosphorothioate, Rp-isomer (Rp-8-Cl-cAMPS) produced amnesia [2].

High impact information on Sp-8-Cl-Camps


  1. Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex. Beaver, C.J., Ji, Q., Fischer, Q.S., Daw, N.W. Nat. Neurosci. (2001) [Pubmed]
  2. Two critical periods for cAMP-dependent protein kinase activity during long-term memory consolidation in the crab Chasmagnathus. Locatelli, F., Maldonado, H., Romano, A. Neurobiology of learning and memory. (2002) [Pubmed]
  3. Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways. Soto, I., Rosenthal, J.J., Blagburn, J.M., Blanco, R.E. J. Neurochem. (2006) [Pubmed]
  4. Blockade of cyclic AMP-dependent protein kinase does not prevent the reverse ocular dominance shift in kitten visual cortex. Shimegi, S., Fischer, Q.S., Yang, Y., Sato, H., Daw, N.W. J. Neurophysiol. (2003) [Pubmed]
  5. Patterned vision causes CRE-mediated gene expression in the visual cortex through PKA and ERK. Cancedda, L., Putignano, E., Impey, S., Maffei, L., Ratto, G.M., Pizzorusso, T. J. Neurosci. (2003) [Pubmed]
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