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Chemical Compound Review:

Sp-8-Cl-Camps cyclohexane-1,2-diamine; platinum(+2)...

Synonyms: AC1L33S3, 8-Chloro-camps, 142754-28-7, 142928-30-1, Quinato(chda)Pt, ...

Locatelli, F. et al., Beaver, C.J. et al., Shimegi, S. et al., Cancedda, L. et al., Soto, I. et al.

Shimegi, Fischer, Yang, Sato, Daw, Beaver, Ji, Fischer, Daw,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on Sp-8-Cl-Camps

Enhancement of PKA activity late in the critical period with Sp-8-Cl-cAMPS did not increase plasticity [1].
In the context-signal learning paradigm of the crab Chasmagnathus, the protein kinase (PKA) activator Sp-5,6-DCl-cBIMPS facilitated long-term memory (LTM) induced by spaced training while the PKA inhibitor 8-chloroadenosine-3', 5'-monophosphorothioate, Rp-isomer (Rp-8-Cl-cAMPS) produced amnesia [2].

High impact information on Sp-8-Cl-Camps

Here we show that inhibition of protein kinase A (PKA) by Rp-8-Cl-cAMPS blocks ocular dominance shifts that occur following monocular deprivation early in the critical period [1].
However, blocking protein kinase A (PKA) with H89 or Rp-8-Cl-cAMPS reduced the up-regulation of both BDNF and TrkB, and reduced pCREB [3].
We have previously shown that the normal OD shift is abolished by chronic infusion of the protein kinase A (PKA) inhibitor, 8-chloroadenosine-3', 5'-cyclic monophosphorothioate, Rp-isomer (Rp-8-Cl-cAMPS), into kitten visual cortex [4].
ERK phosphorylation was strongly reduced by cortical infusion with the cAMP-PKA inhibitor Rp-8-Cl-cAMPS, thus establishing a link between PKA and ERK activation [5].

References

Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex. Beaver, C.J., Ji, Q., Fischer, Q.S., Daw, N.W. Nat. Neurosci. (2001) [Pubmed]
Two critical periods for cAMP-dependent protein kinase activity during long-term memory consolidation in the crab Chasmagnathus. Locatelli, F., Maldonado, H., Romano, A. Neurobiology of learning and memory. (2002) [Pubmed]
Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways. Soto, I., Rosenthal, J.J., Blagburn, J.M., Blanco, R.E. J. Neurochem. (2006) [Pubmed]
Blockade of cyclic AMP-dependent protein kinase does not prevent the reverse ocular dominance shift in kitten visual cortex. Shimegi, S., Fischer, Q.S., Yang, Y., Sato, H., Daw, N.W. J. Neurophysiol. (2003) [Pubmed]
Patterned vision causes CRE-mediated gene expression in the visual cortex through PKA and ERK. Cancedda, L., Putignano, E., Impey, S., Maffei, L., Ratto, G.M., Pizzorusso, T. J. Neurosci. (2003) [Pubmed]

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