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Chemical Compound Review

methylcarbonyl     ethanone

Synonyms: S-acetyl, Acetyl radical, CHEBI:46887, CH3CO, FT-0621835, ...
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Disease relevance of ethanone


High impact information on ethanone

  • Crossing a small barrier the 3s acyl radical can access a CI leading either to a second CC bond breakage or to a hot ground-state acetyl radical [2].
  • LY171883, 1-less than2-hydroxy-3-propyl-4-less than 4-(h-tetrazol-5-yl)butoxy greater than phenyl greater than ethanone, proved to be a potent antagonist of leukotriene (LT) D4 in guinea-pig ileum, trachea and lung parenchyma [3].
  • Although these compounds display different activities, the solid-state and calculated structures are similar: each compound is observed as the neamine tautomer containing an intramolecular hydrogen bond between the ethanone and the amine N atom and the molecular conformations are the same [4].
  • The onset of the CH(3) + CO channel, via isomerization to the acetyl radical, was found to occur at an internal energy of 41 +/- 2 kcal/mol, agreeing well with our calculated isomerization barrier of 40.8 kcal/mol [5].
  • Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor 2,2,2-trifluoro-1-(3-trimethylsilylphenyl) ethanone in dog. Potential for transdermal patch delivery [6].


  1. Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. Li, P.C., Liang, J.T., Huang, H.T., Lin, P.H., Wu, S.N. J. Cell. Physiol. (2002) [Pubmed]
  2. Femtochemistry of Norrish type-I reactions: III. Highly excited ketones--theoretical. Diau, E.W., Kötting, C., Sølling, T.I., Zewail, A.H. Chemphyschem : a European journal of chemical physics and physical chemistry. (2002) [Pubmed]
  3. LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist. Fleisch, J.H., Rinkema, L.E., Haisch, K.D., Swanson-Bean, D., Goodson, T., Ho, P.P., Marshall, W.S. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  4. Structural and molecular modeling studies of quinazolinone anticonvulsants. Duke, N.E., Codding, P.W. Acta Crystallogr., B (1993) [Pubmed]
  5. Dissociation of the ground state vinoxy radical and its photolytic precursor chloroacetaldehyde: electronic nonadiabaticity and the suppression of the H+ketene channel. Miller, J.L., McCunn, L.R., Krisch, M.J., Butler, L.J., Shu, J. The Journal of chemical physics. (2004) [Pubmed]
  6. Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor 2,2,2-trifluoro-1-(3-trimethylsilylphenyl) ethanone in dog. Potential for transdermal patch delivery. Dow, J., Dulery, B.D., Hornsperger, J.M., Di Francesco, G.F., Keshary, P., Haegele, K.D. Arzneimittel-Forschung. (1995) [Pubmed]
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