The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Molecular Conformation

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Molecular Conformation


Biological context of Molecular Conformation


Anatomical context of Molecular Conformation


Associations of Molecular Conformation with chemical compounds


Gene context of Molecular Conformation

  • The SERM raloxifene, which binds to ER and targets a distinct DNA element, may distinguish agonist vs antagonist activity by ER subtype and has unique activity among other SERMs because of its molecular conformation [21].
  • A model is proposed in which the Mcm5-bob1 protein assumes a unique molecular conformation without prior action by either kinase [22].
  • The absence of other known cytokines in the purified NKSF preparations, the unusual molecular conformation of NKSF, the high specific activity of the purified protein, and the spectrum of biological activities distinguish NKSF from other previously described cytokines [23].
  • Even though the mechanism of the differences in the activities of hGSTP1-1 variants toward anti-5-MeCDE versus anti-BPDE remains to be elucidated, it seems that the molecular configuration of the diol epoxide is an important determinant of the activity of hGSTP1-1 isoforms toward polycyclic aromatic hydrocarbon diol epoxides [24].
  • These results indicate that the urethane bond is a novel linker for muscarinic antagonists, and serves to lock the molecular conformation and allows the hydrophobic portion and cationic site of the molecule to bind to M1 and M3 muscarinic receptors [25].

Analytical, diagnostic and therapeutic context of Molecular Conformation


  1. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. van Kooyk, Y., van de Wiel-van Kemenade, P., Weder, P., Kuijpers, T.W., Figdor, C.G. Nature (1989) [Pubmed]
  2. A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution. Fox, R.O., Richards, F.M. Nature (1982) [Pubmed]
  3. Thromboxane molecules do not adopt the prostaglandin hairpin conformation. Langs, D.A., Fortier, S., Erman, M.G., DeTitta, G.T. Nature (1979) [Pubmed]
  4. Thyroid hormone interactions: molecular conformation, protein binding, and hormone action. Cody, V. Endocr. Rev. (1980) [Pubmed]
  5. Beta-N-methylamino-L-alanine neurotoxicity: requirement for bicarbonate as a cofactor. Weiss, J.H., Choi, D.W. Science (1988) [Pubmed]
  6. The role of glycosylation in the molecular conformation and secretion of thyroxine-binding globulin. Murata, Y., Magner, J.A., Refetoff, S. Endocrinology (1986) [Pubmed]
  7. Evidence for preferential stimulation of gastric inhibitory polypeptide secretion in the rat by actively transported carbohydrates and their analogues. Sykes, S., Morgan, L.M., English, J., Marks, V. J. Endocrinol. (1980) [Pubmed]
  8. Self-assembling of glutathione S-transferase/calmodulin fusion protein on chemically modified gold surface. Damrongchai, N., Yun, K., Kobatake, E., Aizawa, M. J. Biotechnol. (1997) [Pubmed]
  9. Sodium spirulan as a potent inhibitor of arterial smooth muscle cell proliferation in vitro. Kaji, T., Okabe, M., Shimada, S., Yamamoto, C., Fujiwara, Y., Lee, J.B., Hayashi, T. Life Sci. (2004) [Pubmed]
  10. Pathogenesis of anti-Ro/SS-A autoantibody-associated cutaneous lupus erythematosus. Sontheimer, R.D., McCauliffe, D.P. Dermatologic clinics. (1990) [Pubmed]
  11. Structural features of Ca2+/calmodulin-dependent protein kinase II revealed by electron microscopy. Kanaseki, T., Ikeuchi, Y., Sugiura, H., Yamauchi, T. J. Cell Biol. (1991) [Pubmed]
  12. Configuration and dynamics of xanthophylls in light-harvesting antennae of higher plants. Spectroscopic analysis of isolated light-harvesting complex of photosystem II and thylakoid membranes. Ruban, A.V., Pascal, A.A., Robert, B., Horton, P. J. Biol. Chem. (2001) [Pubmed]
  13. Mast cell binding of neurotensin. II. Molecular conformation of neurotensin involved in the stereospecific binding to mast cell receptor sites. Lazarus, L.H., Perrin, M.H., Brown, M.R., Rivier, J.E. J. Biol. Chem. (1977) [Pubmed]
  14. Dermatan sulfate: molecular conformations and interactions in the condensed state. Mitra, A.K., Arnott, S., Atkins, E.D., Isaac, D.H. J. Mol. Biol. (1983) [Pubmed]
  15. Effect of the D-Phe2 residue on molecular conformation of an endogenous neuropeptide achatin-I. Comparison of X-ray crystal structures of achatin-I (H-Gly-D-Phe-Ala-Asp-OH) and achatin-II (H-Gly-Phe-Ala-Asp-OH). Ishida, T., In, Y., Inoue, M., Yasuda-Kamatani, Y., Minakata, H., Iwashita, T., Nomoto, K. FEBS Lett. (1992) [Pubmed]
  16. Molecular conformation of a halogen-free thyroxine analog: 4-Methoxy-3,5,3-trimethyl-L-thyronine N-acetyl ethyl ester. Cody, V. Science (1978) [Pubmed]
  17. Dynamics and conformational energetics of a peptide hormone: vasopressin. Hagler, A.T., Osguthorpe, D.J., Dauber-Osguthorpe, P., Hempel, J.C. Science (1985) [Pubmed]
  18. Structure of pressinoic acid: the cyclic moiety of vasopressin. Langs, D.A., Smith, G.D., Stezowski, J.J., Hughes, R.E. Science (1986) [Pubmed]
  19. Three-dimensional structure of the "long" neurotoxin from cobra venom. Walkinshaw, M.D., Saenger, W., Maelicke, A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  20. Light-driven proton translocation by bacteriorhodopsin reconstituted with the phenyl analog of retinal. Bayley, H., Radhakrishnan, R., Huang, K.S., Khorana, H.G. J. Biol. Chem. (1981) [Pubmed]
  21. Mechanism of action of estrogens and selective estrogen receptor modulators. Krishnan, V., Heath, H., Bryant, H.U. Vitam. Horm. (2000) [Pubmed]
  22. The mcm5-bob1 bypass of Cdc7p/Dbf4p in DNA replication depends on both Cdk1-independent and Cdk1-dependent steps in Saccharomyces cerevisiae. Sclafani, R.A., Tecklenburg, M., Pierce, A. Genetics (2002) [Pubmed]
  23. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. Kobayashi, M., Fitz, L., Ryan, M., Hewick, R.M., Clark, S.C., Chan, S., Loudon, R., Sherman, F., Perussia, B., Trinchieri, G. J. Exp. Med. (1989) [Pubmed]
  24. Specificities of human glutathione S-transferase isozymes toward anti-diol epoxides of methylchrysenes. Hu, X., Pal, A., Krzeminski, J., Amin, S., Awasthi, Y.C., Zimniak, P., Singh, S.V. Carcinogenesis (1998) [Pubmed]
  25. Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives. Naito, R., Takeuchi, M., Morihira, K., Hayakawa, M., Ikeda, K., Shibanuma, T., Isomura, Y. Chem. Pharm. Bull. (1998) [Pubmed]
  26. Characterization of organic phases in the interlayer of montmorillonite using FTIR and 13C NMR. Zhu, J., He, H., Zhu, L., Wen, X., Deng, F. Journal of colloid and interface science. (2005) [Pubmed]
  27. Investigation of structure of liquid 2,2,2 trifluoroethanol: neutron diffraction, molecular dynamics, and ab initio quantum chemical study. Bakó, I., Radnai, T., Bellisent Funel, M.C. The Journal of chemical physics. (2004) [Pubmed]
  28. Evidence of increased Gc:actin complexes in pregnant serum: a possible result of trophoblast embolism. Emerson, D.L., Arnaud, P., Galbraith, R.M. American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction. (1983) [Pubmed]
WikiGenes - Universities