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Chemical Compound Review:

Prolacria tetrasodium1-[(2R,3R,4S,5R)- 5-[[[[[[(2R...

Synonyms: Diquas, INS-365, KPY-998, INS365, Up4U, ...

This record was replaced with 148197.

Fujihara, T. et al., Fujihara, T. et al., Sabater, J.R. et al., Min, K. et al., Mundasad, M.V. et al., et al.

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Disease relevance of UppppU

These effects suggest that INS365 is a potential therapeutic agent for use in the treatment of dry eye syndrome [1].
Two adverse events were possibly related to INS365: painless blepharospasm and an increase in lacrimation after 5.0% INS365 instillation [2].

High impact information on UppppU

In addition, the purinoceptor P2Y(2) receptor agonist diquafosol (INS365) is undergoing clinical trials to increase mucus clearance [3].
Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with doses of INS365 as low as 1% [1].
After INS365 application, the periodic acid-Schiff reagent (PAS)-stained area was evaluated in histologic sections of the tarsal and bulbar conjunctiva [1].
CONCLUSION(S): INS45973 and INS365 may interact with P2Y(2) receptors in the cervix and vagina to stimulate vaginal moisture in the estrogen (E)-deprived state [4].
The purpose of this study was to determine whether aerosolized INS316 (UTP) stimulates lung mucociliary clearance (MCC) in sheep and, if so, to compare its effects with INS365, a novel P2Y(2)-receptor agonist [5].

Anatomical context of UppppU

INS365 dose-dependently decreased the PAS staining area of conjunctival goblet cells from 2 to 15 min post-application [6].

Gene context of UppppU

Ocular safety of INS365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease [7].

Analytical, diagnostic and therapeutic context of UppppU

Furthermore, we utilized the rabbit short-term dry eye model to evaluate if INS365 eyedrops could protect against any of the damage produced by blockage of blinking with ocular speculum [6].

References

Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Fujihara, T., Murakami, T., Fujita, H., Nakamura, M., Nakata, K. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
Ocular safety of INS365 ophthalmic solution: a P2Y(2) agonist in healthy subjects. Mundasad, M.V., Novack, G.D., Allgood, V.E., Evans, R.M., Gorden, J.C., Yerxa, B.R. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2001) [Pubmed]
Therapy for chronic obstructive pulmonary disease in the 21st century. Donnelly, L.E., Rogers, D.F. Drugs (2003) [Pubmed]
Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits. Min, K., Munarriz, R., Yerxa, B.R., Goldstein, I., Shaver, S.R., Cowlen, M.S., Traish, A.M. Fertil. Steril. (2003) [Pubmed]
Aerosolization of P2Y(2)-receptor agonists enhances mucociliary clearance in sheep. Sabater, J.R., Mao, Y.M., Shaffer, C., James, M.K., O'Riordan, T.G., Abraham, W.M. J. Appl. Physiol. (1999) [Pubmed]
INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. Fujihara, T., Murakami, T., Nagano, T., Nakamura, M., Nakata, K. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2002) [Pubmed]
Ocular safety of INS365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease. Yerxa, B.R., Mundasad, M., Sylvester, R.N., Garden, J.C., Cooper, M., Kellerman, D.J. Adv. Exp. Med. Biol. (2002) [Pubmed]

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