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MeSH Review

Dry Eye Syndromes

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Disease relevance of Dry Eye Syndromes


High impact information on Dry Eye Syndromes


Chemical compound and disease context of Dry Eye Syndromes

  • PURPOSE: Because purinoceptor P2Y(2) receptor agonists elicit increases in net Cl, fluid transport, and glycoprotein release onto the ocular surface, they are candidates for treatment of dry eye syndrome [10].
  • METHODS: Immunologic anomalies were identified at baseline, before treatment with the masked medication, in a homogeneous series of patients with dry eye syndrome, who were enrolled in a large European multicenter clinical trial (Cyclosporin A Dry Eye Study; Allergan, Irvine, CA) [11].
  • These effects suggest that INS365 is a potential therapeutic agent for use in the treatment of dry eye syndrome [10].
  • Tear proteins of nonstimulated tears of 29 patients (healthy subjects, n = 8; dry-eye syndrome patients, n = 12; diabetic dry-eye patients, n = 9) were electrophoretically separated and stained by SYPRO Orange, followed by Coomassie blue staining [12].
  • Trehalose eye drops in the treatment of dry eye syndrome [13].

Biological context of Dry Eye Syndromes


Anatomical context of Dry Eye Syndromes


Gene context of Dry Eye Syndromes

  • This study also showed that flow cytometry in impression cytology specimens is a reliable tool for exploring the ocular surface at the epithelial level and that CD44, in addition to HLA DR, could be an interesting endpoint for future trials in dry eye syndrome with products based on SH [20].
  • Our results suggest that substantial amounts of ocular mucous glycoprotein are present in the eyes of patients with CP and SJS, diseases which have been previously described as mucin-deficient dry eye syndromes [21].
  • Ocular surface damage and tear lactoferrin in dry eye syndrome [22].
  • "Dry eye syndrome" is a common disorder of the tear film that results from inadequate tear production, excessive tear evaporation or abnormality in mucin or lipid components of the tear film [23].

Analytical, diagnostic and therapeutic context of Dry Eye Syndromes


  1. Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. Avisar, R., Robinson, A., Appel, I., Yassur, Y., Weinberger, D. Cornea (2000) [Pubmed]
  2. Estrogen stimulation of proinflammatory cytokine and matrix metalloproteinase gene expression in human corneal epithelial cells. Suzuki, T., Sullivan, D.A. Cornea (2005) [Pubmed]
  3. Ocular manifestations of Fabry's disease. Klein, P. Journal of the American Optometric Association. (1986) [Pubmed]
  4. An update: spontaneous premature ovarian failure is not an early menopause. Nelson, L.M., Covington, S.N., Rebar, R.W. Fertil. Steril. (2005) [Pubmed]
  5. Hormone replacement therapy and dry eye syndrome. Schaumberg, D.A., Buring, J.E., Sullivan, D.A., Dana, M.R. JAMA (2001) [Pubmed]
  6. Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome. Tsubota, K., Hirai, S., King, L.S., Agre, P., Ishida, N. Lancet (2001) [Pubmed]
  7. Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. Niederkorn, J.Y., Stern, M.E., Pflugfelder, S.C., De Paiva, C.S., Corrales, R.M., Gao, J., Siemasko, K. J. Immunol. (2006) [Pubmed]
  8. Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model. Levin, M.H., Kim, J.K., Hu, J., Verkman, A.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  9. Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Hodges, R.R., Raddassi, I., Zoukhri, D., Toker, A., Kazlauskas, A., Dartt, D.A. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  10. Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Fujihara, T., Murakami, T., Fujita, H., Nakamura, M., Nakata, K. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  11. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Brignole, F., Pisella, P.J., Goldschild, M., De Saint Jean, M., Goguel, A., Baudouin, C. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  12. Analysis of tear protein patterns of dry-eye patients using fluorescent staining dyes and two-dimensional quantification algorithms. Grus, F.H., Sabuncuo, P., Augustin, A.J. Electrophoresis (2001) [Pubmed]
  13. Trehalose eye drops in the treatment of dry eye syndrome. Matsuo, T., Tsuchida, Y., Morimoto, N. Ophthalmology (2002) [Pubmed]
  14. Analysis and design of micro-climate around the human body with respiration by CFD. Murakami, S. Indoor air. (2004) [Pubmed]
  15. Late visual and auditory toxicity of radiotherapy for nasopharyngeal carcinoma. Rosenblatt, E., Brook, O.R., Erlich, N., Miller, B., Joachims, H.Z., Kuten, A. Tumori. (2003) [Pubmed]
  16. Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. Eckstein, A.K., Finkenrath, A., Heiligenhaus, A., Renzing-Köhler, K., Esser, J., Krüger, C., Quadbeck, B., Steuhl, K.P., Gieseler, R.K. Acta ophthalmologica Scandinavica. (2004) [Pubmed]
  17. Salivary gland scintigraphy using technetium-99m-pertechnetate after autotransplantation of the submandibular salivary gland in the correction of dry eye. Lauer, I., Sieg, P., Bähre, M., Richter, E. European journal of nuclear medicine. (1998) [Pubmed]
  18. Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. Kunert, K.S., Tisdale, A.S., Stern, M.E., Smith, J.A., Gipson, I.K. Arch. Ophthalmol. (2000) [Pubmed]
  19. Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1beta in cultured lacrimal gland acinar cells. Beauregard, C., Brandt, P.C., Chiou, G.C. Exp. Eye Res. (2003) [Pubmed]
  20. Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Brignole, F., Pisella, P.J., Dupas, B., Baeyens, V., Baudouin, C. Graefes Arch. Clin. Exp. Ophthalmol. (2005) [Pubmed]
  21. SDS-gradient polyacrylamide gel electrophoresis of individual ocular mucus samples from patients with normal and diseased conjunctiva. Wells, P.A., Ashur, M.L., Foster, C.S. Curr. Eye Res. (1986) [Pubmed]
  22. Ocular surface damage and tear lactoferrin in dry eye syndrome. Danjo, Y., Lee, M., Horimoto, K., Hamano, T. Acta ophthalmologica. (1994) [Pubmed]
  23. Dry eye syndrome. Etiological and therapeutic aspects. Apostol, S., Filip, M., Dragne, C., Filip, A. Oftalmologia (Bucharest, Romania : 1990) (2003) [Pubmed]
  24. Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome. Condon, P.I., McEwen, C.G., Wright, M., Mackintosh, G., Prescott, R.J., McDonald, C. The British journal of ophthalmology. (1999) [Pubmed]
  25. Iodide iontophoresis as a treatment for dry eye syndrome. Horwath-Winter, J., Schmut, O., Haller-Schober, E.M., Gruber, A., Rieger, G. The British journal of ophthalmology. (2005) [Pubmed]
  26. A comparative study of two preservative-free tear substitutes in the management of severe dry eye. Laflamme, M.Y., Swieca, R. Can. J. Ophthalmol. (1988) [Pubmed]
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