Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

SureCN743626 2,2-dimethyl-3H-benzofuran-7- ol

Synonyms: ACMC-1BPGD, CCRIS 9206, AG-E-05150, AIDS-170430, CHEBI:38474, ...

Renzi, B.E. et al., Kim, I.S. et al., Mabury, S.A. et al., Head, I.M. et al.

Kim, Ryu, Hur, Gu, Kim, Shim,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Carbofuran phenol

A specialized segment of the microbial population (Pseudomonas spp.) is purported to carry out most of the degradation but is inefficient at degrading the hydrolysis product, carbofuran phenol [1].

High impact information on Carbofuran phenol

Plasmid analyses together with curing and mating experiments indicated that the presence of a large plasmid (pIH3, greater than 199 kb) was required for the degradation of carbofuran phenol [2].
GC/MS and LC/MS analyses identified 2-hydroxy-3-(3-methylpropan-2-ol) phenol as one of the accumulated metabolites, suggesting that the strain SB5 could degrade carbofuran-7-phenol by hydrolysis at the furanyl ring [3].
Metabolic activation of carbosulfan to carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate) was investigated by measuring plasma concentrations 4, 30, and 240 min after iv (80-120 or 620-640 micrograms/kg) and oral (540-700 or 2030-2190 micrograms/kg) dosages of [carbonyl-14C]carbosulfan [4].

References

Environmental fate of rice pesticides in California. Mabury, S.A., Cox, J.S., Crosby, D.G. Reviews of environmental contamination and toxicology. (1996) [Pubmed]
Characterization of a carbofuran-degrading bacterium and investigation of the role of plasmids in catabolism of the insecticide carbofuran. Head, I.M., Cain, R.B., Suett, D.L. Arch. Microbiol. (1992) [Pubmed]
Sphingomonas sp. strain SB5 degrades carbofuran to a new metabolite by hydrolysis at the furanyl ring. Kim, I.S., Ryu, J.Y., Hur, H.G., Gu, M.B., Kim, S.D., Shim, J.H. J. Agric. Food Chem. (2004) [Pubmed]
Sublethal acute toxicity of carbosulfan [2,3-dihydro-2,2-dimethyl-7-benzofuranyl(d i-n-butylaminosulfenyl)(methyl)carbamate] in the rat after intravenous and oral exposures. Renzi, B.E., Krieger, R.I. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1986) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share