Disease relevance of Carbosulfan

• Chromosomal aberrations in cultured human lymphocytes treated with Marshal and its effective ingredient Carbosulfan [1].
• The use of permethrin and carbosulfan was precluded because of risk of environmental impact and, Bacillus thuringiensis ser [2].
• Sublethal acute toxicity of carbosulfan [2,3-dihydro-2,2-dimethyl-7-benzofuranyl(d i-n-butylaminosulfenyl)(methyl)carbamate] in the rat after intravenous and oral exposures [3].

High impact information on Carbosulfan

• The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice [4].
• The present findings suggest that carbosulfan is a potent genotoxic agent and may be regarded as a potential germ cell mutagen also [4].
• All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P<0.02), micronucleated polychromatic erythrocytes (PCEs) (P<0.05) and sperm head abnormalities (P<0.05) but did not affect the total sperm count [4].
• Surface acidity of montmorillonite and/or formation of surface chelates are probably the key factors of surface catalysis in the case of the hydrolysis of carbosulfan [5].
• While furathiocarb and carbosulfan showed similar patterns of the time-dependence of the micronucleus formation with maximum values after 72 h, benfuracarb exhibited a different behaviour with the maximum increase taking place within 24 h after substance application [6].

Biological context of Carbosulfan

• Induction of sister chromatid exchanges by cypermethrin and carbosulfan in bone marrow cells of mice in vivo [7].
• Monocrotophos and carbosulfan dissipation followed first-order kinetics while others followed second-order kinetics [8].

Associations of Carbosulfan with other chemical compounds

• Montmorillonite enhanced the hydrolysis of carbosulfan and aldicarb [5].
• Determination of carbosulfan and carbofuran residues in plants, soil, and water by gas chromatography [9].
• Response of brain and liver cholinesterases of Nile tilapia, Oreochromis niloticus, to single and multiple exposures of chlorpyrifos and carbosulfan [10].
• Of 27 samples from Côte d'Ivoire, 25 also displayed cross resistance to carbamates as shown by a mortality plateau in bioassays with propoxur and carbosulfan (similar to chlorpyrifos) [11].

Gene context of Carbosulfan

• Screening of all available appropriate compounds has led to the selection of replacement compounds in the microbial (Bacillus thuringiensis H14), pyrethroid (permethrin), and carbamate (carbosulfan) groups [12].
• Reduction in AChE activity was better correlated (r = 0.97) with plasma concentration of [carbosulfan + carbofuran] and plasma carbofuran (r = 0.96) than with plasma carbosulfan (r = 0.73) [3].

Analytical, diagnostic and therapeutic context of Carbosulfan

• Determination of carbosulfan in oranges by high-performance liquid chromatography with post-column fluorescence [13].
• The discriminating concentration of 0.4% carbosulfan (i.e. double the LC100) was determined from bioassays with the susceptible An. gambiae Kisumu strain [14].

References