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Chemical Compound Review

LS-49689     (2,2-dimethyl-3H-benzofuran- 7-yl) N-[(2,2...

Synonyms: AR-1D1457, AC1L3G9Z, AC1Q624H, A6899, Biscarbofuran N,N'-disulfide
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Disease relevance of Carbosulfan


High impact information on Carbosulfan

  • The genotoxic effects of carbosulfan were evaluated using chromosome aberration (CA), bone marrow micronucleus (MN) and sperm abnormality assays in mice [4].
  • The present findings suggest that carbosulfan is a potent genotoxic agent and may be regarded as a potential germ cell mutagen also [4].
  • All the three acute doses (1.25, 2.5 and 5mg/kg) of carbosulfan induced significant dose-dependent increase in the frequency of CA (P<0.02), micronucleated polychromatic erythrocytes (PCEs) (P<0.05) and sperm head abnormalities (P<0.05) but did not affect the total sperm count [4].
  • Surface acidity of montmorillonite and/or formation of surface chelates are probably the key factors of surface catalysis in the case of the hydrolysis of carbosulfan [5].
  • While furathiocarb and carbosulfan showed similar patterns of the time-dependence of the micronucleus formation with maximum values after 72 h, benfuracarb exhibited a different behaviour with the maximum increase taking place within 24 h after substance application [6].

Biological context of Carbosulfan


Associations of Carbosulfan with other chemical compounds


Gene context of Carbosulfan


Analytical, diagnostic and therapeutic context of Carbosulfan


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  2. Risk assessment of etofenprox (Vectron) on non-target aquatic fauna compared with other pesticides used as Simulium larvicide in a tropical environment. Yaméogo, L., Traoré, K., Back, C., Hougard, J.M., Calamari, D. Chemosphere (2001) [Pubmed]
  3. Sublethal acute toxicity of carbosulfan [2,3-dihydro-2,2-dimethyl-7-benzofuranyl(d i-n-butylaminosulfenyl)(methyl)carbamate] in the rat after intravenous and oral exposures. Renzi, B.E., Krieger, R.I. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1986) [Pubmed]
  4. Mutagenic effects of carbosulfan, a carbamate pesticide. Giri, S., Giri, A., Sharma, G.D., Prasad, S.B. Mutat. Res. (2002) [Pubmed]
  5. Influence of clay minerals on the hydrolysis of carbamate pesticides. Wei, J., Furrer, G., Kaufmann, S., Schulin, R. Environ. Sci. Technol. (2001) [Pubmed]
  6. Genotoxic evaluation of three heterocyclic N-methylcarbamate pesticides using the mouse bone marrow micronucleus assay and the Saccharomyces cerevisiae strains D7 and D61.M. Stehrer-Schmid, P., Wolf, H.U. Mutat. Res. (1995) [Pubmed]
  7. Induction of sister chromatid exchanges by cypermethrin and carbosulfan in bone marrow cells of mice in vivo. Giri, S., Giri, A., Sharma, G.D., Prasad, S.B. Mutagenesis (2003) [Pubmed]
  8. Degradation and persistence of cotton pesticides in sandy loam soils from Punjab, Pakistan. Tariq, M.I., Afzal, S., Hussain, I. Environmental research. (2006) [Pubmed]
  9. Determination of carbosulfan and carbofuran residues in plants, soil, and water by gas chromatography. Leppert, B.C., Markle, J.C., Helt, R.C., Fujie, G.H. J. Agric. Food Chem. (1983) [Pubmed]
  10. Response of brain and liver cholinesterases of Nile tilapia, Oreochromis niloticus, to single and multiple exposures of chlorpyrifos and carbosulfan. Chandrasekera, L.K., Pathiratne, A. Bulletin of environmental contamination and toxicology. (2005) [Pubmed]
  11. Distribution of organophosphate and carbamate resistance in Culex pipiens quinquefasciatus (Diptera: Culicidae) in West Africa. Chandre, F., Darriet, F., Doannio, J.M., Rivière, F., Pasteur, N., Guillet, P. J. Med. Entomol. (1997) [Pubmed]
  12. Maintenance of effective control of Simulium damnosum in the face of insecticide resistance. Kurtak, D.C. Acta Leiden. (1990) [Pubmed]
  13. Determination of carbosulfan in oranges by high-performance liquid chromatography with post-column fluorescence. Brooks, M.W., Barros, A. The Analyst. (1995) [Pubmed]
  14. Resistance to carbosulfan in Anopheles gambiae from Ivory Coast, based on reduced sensitivity of acetylcholinesterase. N'Guessan, R., Darriet, F., Guillet, P., Carnevale, P., Traore-Lamizana, M., Corbel, V., Koffi, A.A., Chandre, F. Med. Vet. Entomol. (2003) [Pubmed]
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