The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Furadan     (2,2-dimethyl-3H-benzofuran- 7-yl) N...

Synonyms: Chinufur, Curaterr, Diafuran, Furacarb, Sunfuran, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Furadan


Psychiatry related information on Furadan

  • The effects of concentration (1, 10, 100 microg/L) and duration (4, 8, 12 h) of exposure to carbofuran were assessed on the swimming activity, social interactions, and behavioral responses of goldfish to a flow (0.1 L/min) of water, with or without chironomids [5].
  • Effects of a single dietary exposure to fenthion and carbofuran on the survival, feeding behavior and brain ChE activity of eastern screech-owls, Otus asio and American kestrels, Falco sparverius, were evaluated [6].

High impact information on Furadan

  • A detection limit for carbofuran of approximately 2.5 ng/g of potato was obtained using an atmospheric pressure ionization quadrupole ion trap mass spectrometer [7].
  • Occupational exposure to carbofuran and the incidence of cancer in the Agricultural Health Study [4].
  • Lung cancer risk was 3-fold higher for those with > 109 days of lifetime exposure to carbofuran (RR = 3.05; 95% CI, 0.94-9.87) compared with those with < 9 lifetime exposure days, with a significant dose-response trend for both days of use per year and total years of use [4].
  • Rearrangements, deletions, and loss of individual plasmids that resulted in the loss of the carbofuran-degrading phenotype were observed following introduction of Tn5 [1].
  • A 14-kilobase-pair (kbp) EcoRI DNA fragment that encodes an enzyme capable of rapid hydrolysis of N-methylcarbamate insecticides (carbofuran hydrolase) was cloned from carbofuran-degrading Achromobacter sp. strain WM111 [3].

Chemical compound and disease context of Furadan


Biological context of Furadan


Anatomical context of Furadan

  • Carbofuran-induced histophysiological changes in thyroid of the teleost fish, Channa punctatus (Bloch) [16].
  • EROD activity in cultured hepatocytes was induced by carbofuran (CF), a widely used agricultural pesticide, and by beta-napthoflavone (BNF), a known inducer of CYP1A [17].
  • Impact of carbofuran in the oocyte maturation of catfish, Heteropenustes fossilis (Bloch) [18].
  • Histopathological examination revealed loss of spermato-genesis, degenerative changes in Sertoli cells which are well supported with biochemical studies indicating that carbofuran interferes with the maturation process of testis [19].
  • In HC mice treated with 1 mg/(kg day) carbofuran resulted in 12.63% increase in the ovary weight and showed significant decrease in follicles, corpora lutea and many increased atretic follicles [20].

Associations of Furadan with other chemical compounds


Gene context of Furadan

  • Normalization of HLM data with the average levels of each CYP in native HLM, indicates that carbofuran metabolism is primarily mediated by CYP3A4 (percent total normalized rate (% TNR)=77.5), although CYP1A2 and 2C19 play ancillary roles (% TNR=9.0 and 6.0, respectively) [25].
  • Con A-induced production of interferon-gamma (IFN-gamma) was significantly suppressed by carbofuran, while that of IL-4 was not affected [26].
  • The present study was designed to investigate the comparative in vitro metabolism of carbofuran from human, rat, and mouse liver microsomes (HLM, RLM, MLM, respectively), and characterize the specific enzymes involved in such metabolism, with particular reference to human metabolism [25].
  • Carbofuran decreased Concanavalin A (Con A)- and alloantigen-induced proliferation, and interleukin (IL)-2 production of splenocytes [26].
  • In contrast with the human isoforms, members of the CYP2C family in rats are likely to have a primary role in carbofuran metabolism [25].

Analytical, diagnostic and therapeutic context of Furadan


  1. Plasmid-mediated mineralization of carbofuran by Sphingomonas sp. strain CF06. Feng, X., Ou, L.T., Ogram, A. Appl. Environ. Microbiol. (1997) [Pubmed]
  2. An epidemic of pesticide poisoning in Nicaragua: implications for prevention in developing countries. McConnell, R., Hruska, A.J. American journal of public health. (1993) [Pubmed]
  3. Cloning of a carbofuran hydrolase gene from Achromobacter sp. strain WM111 and its expression in gram-negative bacteria. Tomasek, P.H., Karns, J.S. J. Bacteriol. (1989) [Pubmed]
  4. Occupational exposure to carbofuran and the incidence of cancer in the Agricultural Health Study. Bonner, M.R., Lee, W.J., Sandler, D.P., Hoppin, J.A., Dosemeci, M., Alavanja, M.C. Environ. Health Perspect. (2005) [Pubmed]
  5. Behavioral effects of waterborne carbofuran in goldfish. Saglio, P., Trijasse, S., Azam, D. Arch. Environ. Contam. Toxicol. (1996) [Pubmed]
  6. Possible mechanisms for sensitivity to organophosphorus and carbamate insecticides in eastern screech-owls and American kestrels. Vyas, N.B., Thiele, L.A., Garland, S.C. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1998) [Pubmed]
  7. Determination of carbofuran by on-line immunoaffinity chromatography with coupled-column liquid chromatography/mass spectrometry. Rule, G.S., Mordehai, A.V., Henion, J. Anal. Chem. (1994) [Pubmed]
  8. Mortality and LC50 values for several stages of the marine copepod Tigriopus brevicornis (Müller) exposed to the metals arsenic and cadmium and the pesticides atrazine, carbofuran, dichlorvos, and malathion. Forget, J., Pavillon, J.F., Menasria, M.R., Bocquené, G. Ecotoxicol. Environ. Saf. (1998) [Pubmed]
  9. Effect of safe concentrations of some pesticides on ovarian recrudescence in the freshwater murrel, Channa punctatus (Bl.): a quantitative study. Mani, K., Saxena, P.K. Ecotoxicol. Environ. Saf. (1985) [Pubmed]
  10. Influence and persistence of phorate and carbofuran insecticides on microorganisms in rice field. Das, A.C., Chakravarty, A., Sukul, P., Mukherjee, D. Chemosphere (2003) [Pubmed]
  11. Validation of earthworm toxicity tests by comparison with field studies: a review of benomyl, carbendazim, carbofuran, and carbaryl. Van Gestel, C.A. Ecotoxicol. Environ. Saf. (1992) [Pubmed]
  12. N-acetylcysteine ameliorates carbofuraninduced alterations in lipid composition and activity of membrane bound enzymes. Kamboj, A., Kiran, R., Sandhir, R. Mol. Cell. Biochem. (2006) [Pubmed]
  13. Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine. Kamboj, A., Kiran, R., Sandhir, R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2006) [Pubmed]
  14. Induction of chromosome aberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure. Chauhan, L.K., Pant, N., Gupta, S.K., Srivastava, S.P. Mutat. Res. (2000) [Pubmed]
  15. Nature and fate of insecticide residues inhaled by rats in cigarette smoke. Atallah, Y.H., Dorough, H.W., Thorstenson, J.H. Drug Metab. Dispos. (1975) [Pubmed]
  16. Carbofuran-induced histophysiological changes in thyroid of the teleost fish, Channa punctatus (Bloch). Ram, R.N. Ecotoxicol. Environ. Saf. (1988) [Pubmed]
  17. Impact of copper on biomonitoring enzyme ethoxyresorufin-o-deethylase in cultured catfish hepatocytes. Ghosh, M.C., Ghosh, R., Ray, A.K. Environmental research. (2001) [Pubmed]
  18. Impact of carbofuran in the oocyte maturation of catfish, Heteropenustes fossilis (Bloch). Chatterjee, S., Dutta, A.B., Ghosh, R. Arch. Environ. Contam. Toxicol. (1997) [Pubmed]
  19. In utero and lactational exposure of carbofuran to rats: effect on testes and sperm. Pant, N., Shankar, R., Srivastava, S.P. Human & experimental toxicology. (1997) [Pubmed]
  20. Carbofuran induced block of compensatory ovarian growth in hemicastrated albino mice. Baligar, P.N., Kaliwal, B.B. Toxicology (2004) [Pubmed]
  21. High-sensitivity detection for model organophosphorus and carbamate pesticide with quartz crystal microbalance-precipitation sensor. Kim, N., Park, I.S., Kim, D.K. Biosensors & bioelectronics (2007) [Pubmed]
  22. Detection of carbofuran and metabolites directly or as their heptafluorobutyryl derivatives using gas-liquid or high-pressure liquid chromatography with different detectors. Lawrence, J.F., Lewis, D.A., McLeod, H.A. J. Chromatogr. (1977) [Pubmed]
  23. Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: quantitative studies of immunosuppression by DDT, aroclor 1254, carbaryl, carbofuran, and methylparathion. Street, J.C., Sharma, R.P. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  24. Reversed-phase high-performance liquid chromatography separation of human phenolic metabolites of propoxur (Baygon), carbofuran and carbaryl. Keiser, J.E., Kirby, K.W., Tremmel, F. J. Chromatogr. (1983) [Pubmed]
  25. In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol. Usmani, K.A., Hodgson, E., Rose, R.L. Chem. Biol. Interact. (2004) [Pubmed]
  26. Carbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages. Jeon, S.D., Lim, J.S., Moon, C.K. Toxicol. Lett. (2001) [Pubmed]
  27. Determination of carbofuran and its metabolites. Spittler, T.D., Marafioti, R.A. J. Chromatogr. (1983) [Pubmed]
  28. Chemiluminescence determination of carbofuran and promecarb by flow injection analysis using two photochemical reactions. Pérez-Ruiz, T., Martínez-Lozano, C., Tomás, V., Martín, J. The Analyst. (2002) [Pubmed]
  29. In vivo evaluation of three biomarkers in the mosquitofish (Gambusia yucatana) exposed to pesticides. Rendón-von Osten, J., Ortíz-Arana, A., Guilhermino, L., Soares, A.M. Chemosphere (2005) [Pubmed]
WikiGenes - Universities