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Chemical Compound Review:

AC1L4MHW (3R,4S,5R)-3,4,5,6- tetrahydroxy-2-oxo...

Synonyms: AC1Q5RGF, AR-1I7049, AR-1I7050, 16533-48-5, d-sorbosonic acid, ...

Leduc, S. et al., Shibata, T. et al., Banta, S. et al., Shinjoh, M. et al., Sanli, G. et al., et al.

Leduc, de Troostembergh, Lebeault,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Provitamin C

Corynebacterium 2,5-Diketo-D-gluconic acid reductase (2,5-DKGR) catalyzes the reduction of 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-Keto-L-gulonic acid (2-KLG) [1].
Direct fermentation of 2-keto-L-gulonic acid in recombinant Gluconobacter oxydans [2].
We have achieved production of 2-keto-L-gulonic acid (2-KLGA) in recombinant Pseudomonas putida IFO3738 [3].
A 2-Keto-L-gulonic acid (2-KLG) production process using stationary Pantoea citrea cells and a Corynebacterium 2,5-diketo-D-gluconic acid (2,5-DKG) reductase enzyme has been developed which may represent an improved method of vitamin C biosynthesis [4].

High impact information on Provitamin C

One clone harboring plasmid p7A6 converted L-sorbosone to 2-keto-L-gulonic acid (2KGA) more rapidly than its host did and also converted L-sorbose to 2KGA with no accumulation of L-sorbosone [5].
In this study, the requirements for growth factors of Ketogulonigenium vulgare LMP P-20356, a 2-keto-L-gulonic acid-producing strain of particular interest for the manufacture of vitamin C, were assessed [6].
The industrial production of 2-keto-L-gulonic acid by K. vulgare LMP P-20356 could be improved by using media in which low-molecular-weight reduced folates are present [6].

Chemical compound and disease context of Provitamin C

Metabolic engineering study on the direct fermentation of 2-keto-L-gulonic acid, a key intermediate of L-ascorbic acid in Pseudomonas putida IFO3738 [3].

References

Structural alteration of cofactor specificity in Corynebacterium 2,5-diketo-D-gluconic acid reductase. Sanli, G., Banta, S., Anderson, S., Blaber, M. Protein Sci. (2004) [Pubmed]
Direct fermentation of 2-keto-L-gulonic acid in recombinant Gluconobacter oxydans. Saito, Y., Ishii, Y., Hayashi, H., Yoshikawa, K., Noguchi, Y., Yoshida, S., Soeda, S., Yoshida, M. Biotechnol. Bioeng. (1998) [Pubmed]
Metabolic engineering study on the direct fermentation of 2-keto-L-gulonic acid, a key intermediate of L-ascorbic acid in Pseudomonas putida IFO3738. Shibata, T., Ichikawa, C., Matsuura, M., Takata, Y., Noguchi, Y., Saito, Y., Yamashita, M. J. Biosci. Bioeng. (2000) [Pubmed]
Mathematical modeling of in vitro enzymatic production of 2-Keto-L-gulonic acid using NAD(H) or NADP(H) as cofactors. Banta, S., Boston, M., Jarnagin, A., Anderson, S. Metab. Eng. (2002) [Pubmed]
Cloning and nucleotide sequencing of the membrane-bound L-sorbosone dehydrogenase gene of Acetobacter liquefaciens IFO 12258 and its expression in Gluconobacter oxydans. Shinjoh, M., Tomiyama, N., Asakura, A., Hoshino, T. Appl. Environ. Microbiol. (1995) [Pubmed]
Folate requirements of the 2-keto-L-gulonic acid-producing strain Ketogulonigenium vulgare LMP P-20356 in L-sorbose/CSL medium. Leduc, S., de Troostembergh, J.C., Lebeault, J.M. Appl. Microbiol. Biotechnol. (2004) [Pubmed]

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