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Chemical Compound Review

AC1L4MHW     (3R,4S,5R)-3,4,5,6- tetrahydroxy-2-oxo...

Synonyms: AC1Q5RGF, AR-1I7049, AR-1I7050, 16533-48-5, d-sorbosonic acid, ...
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Disease relevance of Provitamin C


High impact information on Provitamin C

  • One clone harboring plasmid p7A6 converted L-sorbosone to 2-keto-L-gulonic acid (2KGA) more rapidly than its host did and also converted L-sorbose to 2KGA with no accumulation of L-sorbosone [5].
  • In this study, the requirements for growth factors of Ketogulonigenium vulgare LMP P-20356, a 2-keto-L-gulonic acid-producing strain of particular interest for the manufacture of vitamin C, were assessed [6].
  • The industrial production of 2-keto-L-gulonic acid by K. vulgare LMP P-20356 could be improved by using media in which low-molecular-weight reduced folates are present [6].

Chemical compound and disease context of Provitamin C


  1. Structural alteration of cofactor specificity in Corynebacterium 2,5-diketo-D-gluconic acid reductase. Sanli, G., Banta, S., Anderson, S., Blaber, M. Protein Sci. (2004) [Pubmed]
  2. Direct fermentation of 2-keto-L-gulonic acid in recombinant Gluconobacter oxydans. Saito, Y., Ishii, Y., Hayashi, H., Yoshikawa, K., Noguchi, Y., Yoshida, S., Soeda, S., Yoshida, M. Biotechnol. Bioeng. (1998) [Pubmed]
  3. Metabolic engineering study on the direct fermentation of 2-keto-L-gulonic acid, a key intermediate of L-ascorbic acid in Pseudomonas putida IFO3738. Shibata, T., Ichikawa, C., Matsuura, M., Takata, Y., Noguchi, Y., Saito, Y., Yamashita, M. J. Biosci. Bioeng. (2000) [Pubmed]
  4. Mathematical modeling of in vitro enzymatic production of 2-Keto-L-gulonic acid using NAD(H) or NADP(H) as cofactors. Banta, S., Boston, M., Jarnagin, A., Anderson, S. Metab. Eng. (2002) [Pubmed]
  5. Cloning and nucleotide sequencing of the membrane-bound L-sorbosone dehydrogenase gene of Acetobacter liquefaciens IFO 12258 and its expression in Gluconobacter oxydans. Shinjoh, M., Tomiyama, N., Asakura, A., Hoshino, T. Appl. Environ. Microbiol. (1995) [Pubmed]
  6. Folate requirements of the 2-keto-L-gulonic acid-producing strain Ketogulonigenium vulgare LMP P-20356 in L-sorbose/CSL medium. Leduc, S., de Troostembergh, J.C., Lebeault, J.M. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
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