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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

CBiol_001934     3-amino-6-chloro-N- (diaminomethylidene)-5...

Synonyms: AC1L4NUL, AC1Q3PON, AR-1F1860, AR-1F1861, Bio1_000220, ...
 
 
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High impact information on Methylisopropylamiloride

  • However, unlike NHE4 in other tissues, the MIA-resistant component did not transport Li+ in exchange for H+, and reverse transcription-polymerase chain reaction detected NHE4 mRNA in the oocyte but not in later stages [1].
  • A biphasic dose-response curve for HOE-694 and N-methylisopropylamiloride (MIA) suggested that two isoforms (putatively NHE1 and NHE3) are active in the oocyte, 1-cell, and 2-cell stages [1].
  • Trophoblast, whether in intact or collapsed blastocysts, did not show measurable NHE activity or MIA-sensitive activity during recovery from acid load [1].
  • The effects of two amiloride analogues, ethylisopropylamiloride and methylisopropylamiloride, were tested on active Na+ transport and oxidative metabolism of a rabbit proximal renal tubule suspension [2].

References

  1. Developmental changes in the management of acid loads during preimplantation mouse development. Harding, E.A., Gibb, C.A., Johnson, M.H., Cook, D.I., Day, M.L. Biol. Reprod. (2002) [Pubmed]
  2. Amiloride analogues inhibit proximal tubule metabolism. Soltoff, S.P., Cragoe, E.J., Mandel, L.J. Am. J. Physiol. (1986) [Pubmed]
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