Chemical Compound Review:
EIPA 3-amino-6-chloro-N- (diaminomethylidene)-5...
Synonyms:
Lopac-A-3085, CHEMBL517986, AG-J-19240, A3085_SIGMA, CHEBI:606573, ...
- Short-term inhibition of the Na-H exchanger limits acidosis and reduces ischemic injury in the rat heart. Schaefer, S., Ramasamy, R. Cardiovasc. Res. (1997)
- Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat. Buckler, K.J., Vaughan-Jones, R.D., Peers, C., Nye, P.C. J. Physiol. (Lond.) (1991)
- Role of sodium-hydrogen exchange in the proliferation of immortalised lymphoblasts from patients with essential hypertension and normotensive subjects. Rosskopf, D., Schröder, K.J., Siffert, W. Cardiovasc. Res. (1995)
- Effects of Na+/H+ exchange inhibitors in cardiac ischemia. Scholz, W., Albus, U., Linz, W., Martorana, P., Lang, H.J., Schölkens, B.A. J. Mol. Cell. Cardiol. (1992)
- Noradrenaline release from the rat heart during anoxia: effects of changes in extracellular sodium concentration and inhibition of sodium uptake mechanisms. Dart, A.M., Riemersma, R.A. Clin. Exp. Pharmacol. Physiol. (1991)
- Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. Moe, O.W., Miller, R.T., Horie, S., Cano, A., Preisig, P.A., Alpern, R.J. J. Clin. Invest. (1991)
- Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells. Kurtz, A., Kaissling, B., Busse, R., Baier, W. J. Clin. Invest. (1991)
- p160ROCK mediates RhoA activation of Na-H exchange. Tominaga, T., Ishizaki, T., Narumiya, S., Barber, D.L. EMBO J. (1998)
- Control of intracellular pH and growth by fibronectin in capillary endothelial cells. Ingber, D.E., Prusty, D., Frangioni, J.V., Cragoe, E.J., Lechene, C., Schwartz, M.A. J. Cell Biol. (1990)
- Functional expression of the amiloride-sensitive sodium channel in Xenopus oocytes. George, A.L., Staub, O., Geering, K., Rossier, B.C., Kleyman, T.R., Kraehenbuhl, J.P. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Acid-evoked quantal catecholamine secretion from rat phaeochromocytoma cells and its interaction with hypoxia-evoked secretion. Taylor, S.C., Roberts, M.L., Peers, C. J. Physiol. (Lond.) (1999)
- The effects of Na+ replacement on intracellular pH and [Ca2+] in rabbit salivary gland acinar cells. Elliott, A.C., Lau, K.R., Brown, P.D. J. Physiol. (Lond.) (1991)
- 5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death. Andreeva, N., Khodorov, B., Stelmashook, E., Sokolova, S., Cragoe, E., Victorov, I. Neuroscience (1992)
- Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells. Morita, K., Suemitsu, T., Uchiyama, Y., Miyasako, T., Dohi, T. Journal of lipid mediators and cell signalling. (1995)
- Volume-related activities of sodium ion transporters: multinuclear NMR studies of isolated rat hearts. Askenasy, N., Navon, G. Am. J. Physiol. (1996)
- The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport. Weissberg, P.L., Little, P.J., Cragoe, E.J., Bobik, A. Circ. Res. (1989)
- Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1. Lagana, A., Vadnais, J., Le, P.U., Nguyen, T.N., Laprade, R., Nabi, I.R., Noël, J. J. Cell. Sci. (2000)
- Amiloride analogs induce the phosphorylation of elongation factor-2 in vascular endothelial cells. Demolle, D., Lecomte, M., Boutherin-Falson, O., Cragoe, E.J., Nairn, A.C., Boeynaems, J.M. Mol. Pharmacol. (1990)
- Na+/H+ exchange is not operative under low-flow ischemic conditions. Imai, S., Shi, A.Y., Ishibashi, T., Nakazawa, M. J. Mol. Cell. Cardiol. (1991)
- Na+/H(+)-exchange in A6 cells: polarity and vasopressin regulation. Casavola, V., Guerra, L., Helmle-Kolb, C., Reshkin, S.J., Murer, H. J. Membr. Biol. (1992)
- Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride-sensitive Na(+)- and HCO3(-)-dependent mechanism. Neylon, C.B., Little, P.J., Cragoe, E.J., Bobik, A. Circ. Res. (1990)
- Cytoplasmic domain of the ubiquitous Na+/H+ exchanger NHE1 can confer Ca2+ responsiveness to the apical isoform NHE3. Wakabayashi, S., Ikeda, T., Noël, J., Schmitt, B., Orlowski, J., Pouysségur, J., Shigekawa, M. J. Biol. Chem. (1995)
- Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange. Wilson, A.L., Womble, S.W., Prakash, C., Cragoe, E.J., Blair, I.A., Limbird, L.E. Mol. Pharmacol. (1992)
- Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Nakase, I., Niwa, M., Takeuchi, T., Sonomura, K., Kawabata, N., Koike, Y., Takehashi, M., Tanaka, S., Ueda, K., Simpson, J.C., Jones, A.T., Sugiura, Y., Futaki, S. Mol. Ther. (2004)
- The relationship between Na(+)/H(+) exchanger expression and tyrosinase activity in human melanocytes. Smith, D.R., Spaulding, D.T., Glenn, H.M., Fuller, B.B. Exp. Cell Res. (2004)
- Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. Zavoico, G.B., Cragoe, E.J., Feinstein, M.B. J. Biol. Chem. (1986)
- Ca2+ mobilization can occur independent of acceleration of Na+/H+ exchange in thrombin-stimulated human platelets. Zavoico, G.B., Cragoe, E.J. J. Biol. Chem. (1988)
- Conductive sodium pathway with low affinity to amiloride in LLC-PK1 cells and other epithelia. Moran, A., Asher, C., Cragoe, E.J., Garty, H. J. Biol. Chem. (1988)
- Non-genomic regulation of intermediate conductance potassium channels by aldosterone in human colonic crypt cells. Bowley, K.A., Morton, M.J., Hunter, M., Sandle, G.I. Gut (2003)
- Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3. Rajotte, D., Haddad, P., Haman, A., Cragoe, E.J., Hoang, T. J. Biol. Chem. (1992)
- Amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells. Stimulation by prolactin and other mitogens. Too, C.K., Cragoe, E.J., Friesen, H.G. Endocrinology (1987)
- Endothelin 1 stimulates Na+,K(+)-ATPase and Na(+)-K(+)-Cl- cotransport through ETA receptors and protein kinase C-dependent pathway in cerebral capillary endothelium. Kawai, N., Yamamoto, T., Yamamoto, H., McCarron, R.M., Spatz, M. J. Neurochem. (1995)
- Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1. Lang, K.S., Mueller, M.M., Tanneur, V., Wallisch, S., Fedorenko, O., Palmada, M., Lang, F., Bröer, S., Heilig, C.W., Schleicher, E., Weigert, C. Kidney Int. (2003)
- Effects of P-glycoprotein on cell volume regulation in mouse proximal tubule. Miyata, Y., Asano, Y., Muto, S. Am. J. Physiol. Renal Physiol. (2001)
- Role of Na+-H+ and Na+-Ca2+ exchange in hypoxia-related acute astrocyte death. Bondarenko, A., Svichar, N., Chesler, M. Glia (2005)
- Comparison of the protective effects of ischemic preconditioning and the Na+/H+ exchanger blockade. Mosca, S.M., Cingolani, H.E. Naunyn Schmiedebergs Arch. Pharmacol. (2000)
- Effects of inhibitors of enzymatic and cellular pH-regulating systems on central sympathetic chemosensitivity. König, S.A., Offner, B., Czachurski, J., Seller, H. Pflugers Arch. (1995)
- Volumes and Na+/H+ antiporter activity of lymphocytes in patients with congestive heart failure. Christ, M., Klauss, V., Pliml, W., Theisen, K., Wehling, M. The Clinical investigator. (1994)
- Regulation by PKC isoforms of Na(+)/H(+) exchanger in luminal membrane vesicles isolated from cortical tubules. Karim, Z.G., Chambrey, R., Chalumeau, C., Defontaine, N., Warnock, D.G., Paillard, M., Poggioli, J. Am. J. Physiol. (1999)