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MeSH Review

Kidney Tubules, Proximal

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Disease relevance of Kidney Tubules, Proximal


High impact information on Kidney Tubules, Proximal

  • Thus, partial as opposed to complete inhibition of metabolism reveals that different relationships exist between net sodium transport and the transport of phosphate, glucose, and PAH by the proximal renal tubule [6].
  • Chloride transport in the proximal renal tubule [7].
  • We conclude that parathyroid hormone inhibits proximal renal tubule sodium-phosphate cotransport through a signaling complex dependent upon an AKAP [8].
  • Both DCXR and its mRNA are highly expressed in kidney and liver of human and rodent tissues, and the protein was localized primarily to the inner membranes of the proximal renal tubules in murine kidneys [9].
  • Previous studies have identified two high-molecular weight (280 and 330 kd) glycoproteins expressed by coated pits of the proximal renal tubule and yolk sac and have further established that, in vivo, antibodies to gp280 but not to gp330 induce fetal malformations [10].
  • The peptide transporter PEPT2 was cloned from the proximal kidney tubule cell line, LLC-PK1 [11].

Chemical compound and disease context of Kidney Tubules, Proximal

  • BACKGROUND: Cystinuria is the second most frequent autosomal recessively inherited disorder in Europe, and it is based on a disturbance of the transepithelial transport of cystine and amino acids in the proximal renal tubule as well as in the intestinum [12].

Biological context of Kidney Tubules, Proximal


Anatomical context of Kidney Tubules, Proximal


Associations of Kidney Tubules, Proximal with chemical compounds


Gene context of Kidney Tubules, Proximal

  • In conclusion, PTH activates MAPK in both distal and proximal renal tubule cells [28].
  • Calcitonin (CT), and PTH and PTH-related protein (PTHrP) stimulated urinary excretion of phosphate is brought about through inhibition of Na/P04 cotransport in proximal renal tubules [29].
  • Increased circulating levels of FGF23 have been reported in patients with renal phosphate-wasting disorders, but it is unclear whether FGF23 is the direct mediator responsible for the decreased phosphate transport at the proximal renal tubules and the altered vitamin D metabolism associated with these states [30].
  • Megalin is expressed in various epithelia including proximal kidney tubules, intestine, and ependymal cells [31].
  • These active vitamin D compounds also counteracted the effects of PTHrP at the proximal renal tubules, as reflected by a decrease in phosphate excretion [32].

Analytical, diagnostic and therapeutic context of Kidney Tubules, Proximal



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  17. Coupling between proximal tubular transport processes. Studies with ouabain, SITS and HCO3-free solutions. Ullrich, K.J., Capasso, G., Rumrich, G., Papavassiliou, F., Klöss, S. Pflugers Arch. (1977) [Pubmed]
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  19. Characterization of sodium-dependent and sodium-independent nucleoside transport systems in rabbit brush-border and basolateral plasma-membrane vesicles from the renal outer cortex. Williams, T.C., Doherty, A.J., Griffith, D.A., Jarvis, S.M. Biochem. J. (1989) [Pubmed]
  20. Parathyroid hormone degradation by chymotrypsin-like endopeptidase in the opossum kidney cell. Yamaguchi, T., Fukase, M., Nishikawa, M., Fujimi, T., Fujita, T. Endocrinology (1988) [Pubmed]
  21. Transport interactions of different organic cations during their excretion by the intact rat kidney. Pietruck, F., Ullrich, K.J. Kidney Int. (1995) [Pubmed]
  22. Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Gupta, A., Tenenhouse, H.S., Hoag, H.M., Wang, D., Khadeer, M.A., Namba, N., Feng, X., Hruska, K.A. Bone (2001) [Pubmed]
  23. Detection of two forms of GP330. Their role in Heymann nephritis. Bachinsky, D.R., Zheng, G., Niles, J.L., McLaughlin, M., Abbate, M., Andres, G., Brown, D., McCluskey, R.T. Am. J. Pathol. (1993) [Pubmed]
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  25. Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity. Miyauchi, A., Fukase, M., Tsutsumi, M., Fujita, T. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
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  29. Calcitonin inhibits phosphate uptake in opossum kidney cells stably transfected with a porcine calcitonin receptor. Muff, R., Kaufmann, M., Born, W., Fischer, J.A. Endocrinology (1994) [Pubmed]
  30. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Bai, X., Miao, D., Li, J., Goltzman, D., Karaplis, A.C. Endocrinology (2004) [Pubmed]
  31. Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands. Gliemann, J. Biol. Chem. (1998) [Pubmed]
  32. 1,25-dihydroxyvitamin D3 as well as its analogue OCT lower blood calcium through inhibition of bone resorption in hypercalcemic rats with continuous parathyroid hormone-related peptide infusion. Endo, K., Katsumata, K., Hirata, M., Masaki, T., Kubodera, N., Nakamura, T., Ikeda, K., Ogata, E. J. Bone Miner. Res. (2000) [Pubmed]
  33. Renal catabolism of advanced glycation end products: the fate of pentosidine. Miyata, T., Ueda, Y., Horie, K., Nangaku, M., Tanaka, S., van Ypersele de Strihou, C., Kurokawa, K. Kidney Int. (1998) [Pubmed]
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