Disease relevance of Bamifyllin

• These pharmacological data represent new support for the protecting effect of bamifylline against respiratory damage induced by well known anaphylaxis mediators [1].
• Severe bronchial asthma improved on bamifylline. Case report and review [2].

High impact information on Bamifyllin

• Determination of bamifylline hydrochloride impurities in bulk material and pharmaceutical forms using liquid chromatography with ultraviolet detection [3].
• Pharmacokinetics of bamifylline during chronic therapy [4].
• Pharmacological activity of bamifylline on lung anaphylaxis: in vitro studies [5].
• Moreover, they suggest that bamifylline acts on cardiac muscle by a mechanism, probably linked to the Ca+(+)-movements across the cardiac membrane, able to outweigh the effects due to its antiphosphodiesterase activity [6].
• The cardiac effects of bamifylline (Bamifix), an alkylxanthine derivative, were evaluated on in vivo and in vitro cardiac preparations and compared with those of theophylline and enprofylline [6].

Biological context of Bamifyllin

• Evidence of pulmonary tropism of bamifylline and its main active metabolite [7].

Associations of Bamifyllin with other chemical compounds

• The 300 mg single- and multiple-dose experiments were performed by comparing Bamifylline with 200 mg of Theophylline within the confines of controlled double-blind randomized cross-over studies [8].

Analytical, diagnostic and therapeutic context of Bamifyllin

• HPLC method for assay of bamifylline in plasma from neonates [9].
• The metabolic fate and pharmacokinetics of Bamifylline have been investigated by high performance liquid- and gas-chromatography techniques and radio-isotopic methods in several experiments following oral and intravenous administration of single and repeated doses of 300 mg, 600 mg and 900 mg of this drug [8].

References